Integrated transcriptomic and proteomic profiling of colonic tissue in interleukin-10-deficient mice

Integrated transcriptomic and proteomic profiling of colonic tissue in interleukin-10-deficient mice

Abstract Interleukin (IL)-10, a prominent anti-inflammatory cytokine predominantly secreted by various immune cells, plays a crucial role in the pathophysiological mechanisms of inflammatory bowel disease (IBD). Mice deficient in IL-10 (IL-10−/−) progressively develop features of idiopathic enteroco...

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Main Authors: Lili Li, Chunxiang Ma, Kexin Chen, Yongbin Jia, Yushan Wu, Hao Lin, Rui Cheng, Mingshan Jiang, Zhen Zeng, Jingjing Chen, Jiangmei Pang, Jiaxin Li, Hu Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Data
Online Access:https://doi.org/10.1038/s41597-025-05212-4
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