MORE-RNAseq: a pipeline for quantifying retrotransposition-capable LINE1 expression based on RNA-seq data

MORE-RNAseq: a pipeline for quantifying retrotransposition-capable LINE1 expression based on RNA-seq data

Retrotransposon long interspersed nuclear element-1 (LINE-1, L1) constitutes a large proportion of the mammalian genome. A fraction of L1s, which have no deleterious mutations in the structure, can amplify their copies via a process called retrotransposition (RT). RT affects genome stability and gen...

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Bibliographic Details
Main Authors: Yutaka Nakachi, Jianbin Du, Risa Watanabe, Yutaro Yanagida, Miki Bundo, Kazuya Iwamoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Bioinformatics
Subjects:
LINE-1 (L1)
expression
RNA-seq
retrotransposon
transcription
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fbinf.2025.1575346/full
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