Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPARδ and Adiponectin in ApoE KO Mice
Aster glehni is well known for its therapeutic properties. This study was performed to investigate the effects of A. glehni on nonalcoholic fatty liver disease (NAFLD) in atherosclerotic condition, by determining the levels of biomarkers related to lipid metabolism and inflammation in serum, liver,...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2017/3912567 |
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| author | Yong-Jik Lee Yoo-Na Jang Yoon-Mi Han Hyun-Min Kim Jong-Min Jeong Min Jeoung Son Chang Bae Jin Hyoung Ja Kim Hong Seog Seo |
| author_facet | Yong-Jik Lee Yoo-Na Jang Yoon-Mi Han Hyun-Min Kim Jong-Min Jeong Min Jeoung Son Chang Bae Jin Hyoung Ja Kim Hong Seog Seo |
| author_sort | Yong-Jik Lee |
| collection | DOAJ |
| description | Aster glehni is well known for its therapeutic properties. This study was performed to investigate the effects of A. glehni on nonalcoholic fatty liver disease (NAFLD) in atherosclerotic condition, by determining the levels of biomarkers related to lipid metabolism and inflammation in serum, liver, and adipose tissue. Body and abdominal adipose tissue weights and serum triglyceride level decreased in all groups treated with A. glehni. Serum adiponectin concentration and protein levels of peroxisome proliferator-activated receptor δ, 5′ adenosine monophosphate-activated protein kinase, acetyl-CoA carboxylase, superoxide dismutase, and PPARγ coactivator 1-alpha in liver tissues increased in the groups treated with A. glehni. Conversely, protein levels of ATP citrate lyase, fatty acid synthase, tumor necrosis factor α, and 3-hydroxy-3-methylglutaryl-CoA reductase and the concentrations of interleukin 6 and reactive oxygen species decreased upon A. glehni. Triglyceride concentration in the liver was lower in mice treated with A. glehni than in control mice. Lipid accumulation in HepG2 and 3T3-L1 cells decreased upon A. glehni treatment; this effect was suppressed in the presence of the PPARδ antagonist, GSK0660. Our findings suggest that A. glehni extracts may ameliorate NAFLD through regulation of PPARδ, adiponectin, and the related subgenes. |
| format | Article |
| id | doaj-art-807c8f89be494c21be51b2ffa345ee70 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-807c8f89be494c21be51b2ffa345ee702025-08-20T03:35:15ZengWileyPPAR Research1687-47571687-47652017-01-01201710.1155/2017/39125673912567Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPARδ and Adiponectin in ApoE KO MiceYong-Jik Lee0Yoo-Na Jang1Yoon-Mi Han2Hyun-Min Kim3Jong-Min Jeong4Min Jeoung Son5Chang Bae Jin6Hyoung Ja Kim7Hong Seog Seo8Cardiovascular Center, Korea University, Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul 08308, Republic of KoreaCardiovascular Center, Korea University, Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul 08308, Republic of KoreaCardiovascular Center, Korea University, Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul 08308, Republic of KoreaCardiovascular Center, Korea University, Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul 08308, Republic of KoreaCardiovascular Center, Korea University, Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul 08308, Republic of KoreaMolecular Recognition Research Center, Materials and Life Science Research Division, Korea Institute of Science and Technology, Hwarangno 14 Gil 5, Seoul 136-791, Republic of KoreaMolecular Recognition Research Center, Materials and Life Science Research Division, Korea Institute of Science and Technology, Hwarangno 14 Gil 5, Seoul 136-791, Republic of KoreaMolecular Recognition Research Center, Materials and Life Science Research Division, Korea Institute of Science and Technology, Hwarangno 14 Gil 5, Seoul 136-791, Republic of KoreaCardiovascular Center, Korea University, Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul 08308, Republic of KoreaAster glehni is well known for its therapeutic properties. This study was performed to investigate the effects of A. glehni on nonalcoholic fatty liver disease (NAFLD) in atherosclerotic condition, by determining the levels of biomarkers related to lipid metabolism and inflammation in serum, liver, and adipose tissue. Body and abdominal adipose tissue weights and serum triglyceride level decreased in all groups treated with A. glehni. Serum adiponectin concentration and protein levels of peroxisome proliferator-activated receptor δ, 5′ adenosine monophosphate-activated protein kinase, acetyl-CoA carboxylase, superoxide dismutase, and PPARγ coactivator 1-alpha in liver tissues increased in the groups treated with A. glehni. Conversely, protein levels of ATP citrate lyase, fatty acid synthase, tumor necrosis factor α, and 3-hydroxy-3-methylglutaryl-CoA reductase and the concentrations of interleukin 6 and reactive oxygen species decreased upon A. glehni. Triglyceride concentration in the liver was lower in mice treated with A. glehni than in control mice. Lipid accumulation in HepG2 and 3T3-L1 cells decreased upon A. glehni treatment; this effect was suppressed in the presence of the PPARδ antagonist, GSK0660. Our findings suggest that A. glehni extracts may ameliorate NAFLD through regulation of PPARδ, adiponectin, and the related subgenes.http://dx.doi.org/10.1155/2017/3912567 |
| spellingShingle | Yong-Jik Lee Yoo-Na Jang Yoon-Mi Han Hyun-Min Kim Jong-Min Jeong Min Jeoung Son Chang Bae Jin Hyoung Ja Kim Hong Seog Seo Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPARδ and Adiponectin in ApoE KO Mice PPAR Research |
| title | Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPARδ and Adiponectin in ApoE KO Mice |
| title_full | Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPARδ and Adiponectin in ApoE KO Mice |
| title_fullStr | Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPARδ and Adiponectin in ApoE KO Mice |
| title_full_unstemmed | Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPARδ and Adiponectin in ApoE KO Mice |
| title_short | Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPARδ and Adiponectin in ApoE KO Mice |
| title_sort | caffeoylquinic acid rich extract of aster glehni f schmidt ameliorates nonalcoholic fatty liver through the regulation of pparδ and adiponectin in apoe ko mice |
| url | http://dx.doi.org/10.1155/2017/3912567 |
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