Intraocular inflammation after intravitreal injection of aflibercept 8 mg for treatment-refractory neovascular age-related macular degeneration: a case report
Abstract Background To report a case of intraocular inflammation (IOI) after intravitreal injection of aflibercept 8 mg for treatment-refractory neovascular age-related macular degeneration. Case presentation An 80-year-old man with diabetes mellitus had neovascular age-related macular degeneration...
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BMC
2025-01-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-024-03827-6 |
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| author | Nozomu Hashiya Ichiro Maruko Yuri Miyaguchi Ruka Maruko Taiji Hasegawa Tomohiro Iida |
| author_facet | Nozomu Hashiya Ichiro Maruko Yuri Miyaguchi Ruka Maruko Taiji Hasegawa Tomohiro Iida |
| author_sort | Nozomu Hashiya |
| collection | DOAJ |
| description | Abstract Background To report a case of intraocular inflammation (IOI) after intravitreal injection of aflibercept 8 mg for treatment-refractory neovascular age-related macular degeneration. Case presentation An 80-year-old man with diabetes mellitus had neovascular age-related macular degeneration refractory to treatment with aflibercept 2 mg. Despite ten injections of faricimab, the exudation remained, and we switched to brolucizumab, which resulted in a mild IOI. The IOI improved with only topical steroids, and we switched back to aflibercept 2 mg for the exudation. However, the exudation remained, and we decided to switch to aflibercept 8 mg after careful discussion with the patient. Two weeks later, he experienced minor ocular pain and photophobia. One month later, although a dry macula was achieved, severe visual impairment occurred due to anterior chamber inflammation, retinal vasculitis, and retinal vascular occlusion. We diagnosed the severe IOI following aflibercept 8 mg and immediately started steroid eye drops and a sub-Tenon injection of triamcinolone acetonide. Although the inflammation resolved, his visual acuity did not improve. Conclusions This case demonstrated a potential dose-dependent inflammatory response following aflibercept 8 mg, which did not occur with aflibercept 2 mg in patients with a history of intraocular inflammation. |
| format | Article |
| id | doaj-art-8079b52ce3b9479f800a96c16fed24fc |
| institution | Kabale University |
| issn | 1471-2415 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj-art-8079b52ce3b9479f800a96c16fed24fc2025-01-26T12:21:03ZengBMCBMC Ophthalmology1471-24152025-01-012511610.1186/s12886-024-03827-6Intraocular inflammation after intravitreal injection of aflibercept 8 mg for treatment-refractory neovascular age-related macular degeneration: a case reportNozomu Hashiya0Ichiro Maruko1Yuri Miyaguchi2Ruka Maruko3Taiji Hasegawa4Tomohiro Iida5Department of Ophthalmology, Tokyo Women’s Medical UniversityDepartment of Ophthalmology, Tokyo Women’s Medical UniversityDepartment of Ophthalmology, Tokyo Women’s Medical UniversityDepartment of Ophthalmology, Tokyo Women’s Medical UniversityDepartment of Ophthalmology, Tokyo Women’s Medical UniversityDepartment of Ophthalmology, Tokyo Women’s Medical UniversityAbstract Background To report a case of intraocular inflammation (IOI) after intravitreal injection of aflibercept 8 mg for treatment-refractory neovascular age-related macular degeneration. Case presentation An 80-year-old man with diabetes mellitus had neovascular age-related macular degeneration refractory to treatment with aflibercept 2 mg. Despite ten injections of faricimab, the exudation remained, and we switched to brolucizumab, which resulted in a mild IOI. The IOI improved with only topical steroids, and we switched back to aflibercept 2 mg for the exudation. However, the exudation remained, and we decided to switch to aflibercept 8 mg after careful discussion with the patient. Two weeks later, he experienced minor ocular pain and photophobia. One month later, although a dry macula was achieved, severe visual impairment occurred due to anterior chamber inflammation, retinal vasculitis, and retinal vascular occlusion. We diagnosed the severe IOI following aflibercept 8 mg and immediately started steroid eye drops and a sub-Tenon injection of triamcinolone acetonide. Although the inflammation resolved, his visual acuity did not improve. Conclusions This case demonstrated a potential dose-dependent inflammatory response following aflibercept 8 mg, which did not occur with aflibercept 2 mg in patients with a history of intraocular inflammation.https://doi.org/10.1186/s12886-024-03827-6Aflibercept 8 mgIntraocular inflammationRetinal vasculitisRetinal vascular occlusionTreatment-refractoryNeovascular age-related macular degeneration |
| spellingShingle | Nozomu Hashiya Ichiro Maruko Yuri Miyaguchi Ruka Maruko Taiji Hasegawa Tomohiro Iida Intraocular inflammation after intravitreal injection of aflibercept 8 mg for treatment-refractory neovascular age-related macular degeneration: a case report BMC Ophthalmology Aflibercept 8 mg Intraocular inflammation Retinal vasculitis Retinal vascular occlusion Treatment-refractory Neovascular age-related macular degeneration |
| title | Intraocular inflammation after intravitreal injection of aflibercept 8 mg for treatment-refractory neovascular age-related macular degeneration: a case report |
| title_full | Intraocular inflammation after intravitreal injection of aflibercept 8 mg for treatment-refractory neovascular age-related macular degeneration: a case report |
| title_fullStr | Intraocular inflammation after intravitreal injection of aflibercept 8 mg for treatment-refractory neovascular age-related macular degeneration: a case report |
| title_full_unstemmed | Intraocular inflammation after intravitreal injection of aflibercept 8 mg for treatment-refractory neovascular age-related macular degeneration: a case report |
| title_short | Intraocular inflammation after intravitreal injection of aflibercept 8 mg for treatment-refractory neovascular age-related macular degeneration: a case report |
| title_sort | intraocular inflammation after intravitreal injection of aflibercept 8 mg for treatment refractory neovascular age related macular degeneration a case report |
| topic | Aflibercept 8 mg Intraocular inflammation Retinal vasculitis Retinal vascular occlusion Treatment-refractory Neovascular age-related macular degeneration |
| url | https://doi.org/10.1186/s12886-024-03827-6 |
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