Impact of dual sensory impairment on the risk of incident dementia: a protocol for a systematic review and meta-analysis
Introduction Strong evidence supports the importance of potentially modifiable risk factors for dementia, with sensory loss, particularly visual and hearing impairment, being prominent among them. While single sensory impairment has been widely investigated, the influence of concomitant visual and h...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2024-10-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/10/e084654.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850284896926302208 |
|---|---|
| author | Adrian Fuente Ahmed Amine Alaoui Daniele Urso Stefano Giannoni-Luza Jeremy Ting Samir Jabbour |
| author_facet | Adrian Fuente Ahmed Amine Alaoui Daniele Urso Stefano Giannoni-Luza Jeremy Ting Samir Jabbour |
| author_sort | Adrian Fuente |
| collection | DOAJ |
| description | Introduction Strong evidence supports the importance of potentially modifiable risk factors for dementia, with sensory loss, particularly visual and hearing impairment, being prominent among them. While single sensory impairment has been widely investigated, the influence of concomitant visual and hearing impairment is still not clear. Thus, in this systematic review, we aim to evaluate the risk of developing all-cause dementia due to dual sensory (visual and hearing) impairment and to comprehensively explore possible sources of heterogeneity.Methods and analysis This protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 2015 statement and has been registered on the PROSPERO international prospective register of systematic reviews. Our literature search will include two databases: MEDLINE-PubMed and Embase. The search strategy will consist of terms tailored for each database. We will include peer-reviewed longitudinal cohort studies reporting HRs. Screening and selection of articles will be performed independently by at least two reviewers using the Covidence systematic review manager. Discrepancies will be resolved by consensus. Data will be collected on study design, location, study setting, follow-up years, baseline demographics, sensory impairment and dementia diagnosis ascertainment, and number of adjusted covariates. The quality of the included studies will be evaluated using the Newcastle-Ottawa Scale for cohort studies. If meta-analysis is possible, we will perform DerSimonian-Laird random-effects models of HRs using the most adjusted model from each study. Subgroup analyses and meta-regressions are planned as a function of study setting, geographical location, sensory impairment and dementia diagnosis ascertainment, follow-up years and number of adjusted covariates.Ethics and dissemination Ethical approval is not required because this study involves data already published by other authors. Our findings will be disseminated by a peer-reviewed publication and presentations at relevant scientific conferences. The results will support the understanding of dementia’s modifiable risk factors and may motivate the development of screening interventions to prevent dementia.PROSPERO registration number CRD42023493401. |
| format | Article |
| id | doaj-art-8072b1c398af452fbcfb8aa6d7092d42 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-8072b1c398af452fbcfb8aa6d7092d422025-08-20T01:47:26ZengBMJ Publishing GroupBMJ Open2044-60552024-10-01141010.1136/bmjopen-2024-084654Impact of dual sensory impairment on the risk of incident dementia: a protocol for a systematic review and meta-analysisAdrian Fuente0Ahmed Amine Alaoui1Daniele Urso2Stefano Giannoni-Luza3Jeremy Ting4Samir Jabbour5Master of Public Health in Epidemiology (MPH-EPI), Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USAMaster of Public Health in Epidemiology (MPH-EPI), Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USAMaster of Public Health in Epidemiology (MPH-EPI), Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USAResearch Department, SYNAPSIS Mental Health and Neurology Non-Profit Organization, Lima, PeruMaster of Public Health in Epidemiology (MPH-EPI), Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USAMaster of Public Health in Epidemiology (MPH-EPI), Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USAIntroduction Strong evidence supports the importance of potentially modifiable risk factors for dementia, with sensory loss, particularly visual and hearing impairment, being prominent among them. While single sensory impairment has been widely investigated, the influence of concomitant visual and hearing impairment is still not clear. Thus, in this systematic review, we aim to evaluate the risk of developing all-cause dementia due to dual sensory (visual and hearing) impairment and to comprehensively explore possible sources of heterogeneity.Methods and analysis This protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 2015 statement and has been registered on the PROSPERO international prospective register of systematic reviews. Our literature search will include two databases: MEDLINE-PubMed and Embase. The search strategy will consist of terms tailored for each database. We will include peer-reviewed longitudinal cohort studies reporting HRs. Screening and selection of articles will be performed independently by at least two reviewers using the Covidence systematic review manager. Discrepancies will be resolved by consensus. Data will be collected on study design, location, study setting, follow-up years, baseline demographics, sensory impairment and dementia diagnosis ascertainment, and number of adjusted covariates. The quality of the included studies will be evaluated using the Newcastle-Ottawa Scale for cohort studies. If meta-analysis is possible, we will perform DerSimonian-Laird random-effects models of HRs using the most adjusted model from each study. Subgroup analyses and meta-regressions are planned as a function of study setting, geographical location, sensory impairment and dementia diagnosis ascertainment, follow-up years and number of adjusted covariates.Ethics and dissemination Ethical approval is not required because this study involves data already published by other authors. Our findings will be disseminated by a peer-reviewed publication and presentations at relevant scientific conferences. The results will support the understanding of dementia’s modifiable risk factors and may motivate the development of screening interventions to prevent dementia.PROSPERO registration number CRD42023493401.https://bmjopen.bmj.com/content/14/10/e084654.full |
| spellingShingle | Adrian Fuente Ahmed Amine Alaoui Daniele Urso Stefano Giannoni-Luza Jeremy Ting Samir Jabbour Impact of dual sensory impairment on the risk of incident dementia: a protocol for a systematic review and meta-analysis BMJ Open |
| title | Impact of dual sensory impairment on the risk of incident dementia: a protocol for a systematic review and meta-analysis |
| title_full | Impact of dual sensory impairment on the risk of incident dementia: a protocol for a systematic review and meta-analysis |
| title_fullStr | Impact of dual sensory impairment on the risk of incident dementia: a protocol for a systematic review and meta-analysis |
| title_full_unstemmed | Impact of dual sensory impairment on the risk of incident dementia: a protocol for a systematic review and meta-analysis |
| title_short | Impact of dual sensory impairment on the risk of incident dementia: a protocol for a systematic review and meta-analysis |
| title_sort | impact of dual sensory impairment on the risk of incident dementia a protocol for a systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/14/10/e084654.full |
| work_keys_str_mv | AT adrianfuente impactofdualsensoryimpairmentontheriskofincidentdementiaaprotocolforasystematicreviewandmetaanalysis AT ahmedaminealaoui impactofdualsensoryimpairmentontheriskofincidentdementiaaprotocolforasystematicreviewandmetaanalysis AT danieleurso impactofdualsensoryimpairmentontheriskofincidentdementiaaprotocolforasystematicreviewandmetaanalysis AT stefanogiannoniluza impactofdualsensoryimpairmentontheriskofincidentdementiaaprotocolforasystematicreviewandmetaanalysis AT jeremyting impactofdualsensoryimpairmentontheriskofincidentdementiaaprotocolforasystematicreviewandmetaanalysis AT samirjabbour impactofdualsensoryimpairmentontheriskofincidentdementiaaprotocolforasystematicreviewandmetaanalysis |