Association of Fetuin-A and inflammation levels with cardiac calcification in maintenance hemodialysis patients
Objective To explore the importance of nontraditional risk factors for cardiac valve calcification in maintenance hemodialysis(MHD) patients.Methods Ninety-nine patients(53 males,and 46 females) subject to MHD for at least 6 months in the Blood Purification Center of the affiliated hospital of Qingd...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2015-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57921562&Fpath=home&index=0 |
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| Summary: | Objective To explore the importance of nontraditional risk factors for cardiac valve calcification in maintenance hemodialysis(MHD) patients.Methods Ninety-nine patients(53 males,and 46 females) subject to MHD for at least 6 months in the Blood Purification Center of the affiliated hospital of Qingdao University before March 2014,aged over 18 years were enrolled in this study.Echocardiography was used to detect the calcification.Patients were divided into two groups based on the echocardiographic findings,one as valve calcification group,and the other as valve non-calcification group.In addition,patients were separated into three groups based on the number of valve calcification:group A as zero valve calcification,group B as one valve calcification and group C as two valves calcification.Fetuin-A,IL-6 and hs-CRP were measured by ELISA.Results In the 99 patients,cardiac valve calcification was found in 40 patients(40.4%),in which aortic valve calcification was found in 30 patients(30.3%),mitral valve calcification in 27 patients(27.3%),and both aortic and mitral valves calcification in 17 patients(17.2%).Patients with valve calcification had older age,longer dialysis duration,higher serum phosphate and higher levels of intact parathyroid hormone,hs-CRP and IL-6,lower levels of albumin and Fetuin-A than those of the patients without valve calcification.Patient’s age,dialysis duration,serum phosphate,calcium phosphorus product(Ca× P),and the levels of IL-6 and hs-CRP were increased with the number of valves calcified,and serum albumin and FetuinA levels were decreased with the number of valves calcified.Serum Fetuin-A levels were negatively correlated with age(r=-0.246,P = 0.014),dialysis duration(r=-0.297,P = 0.003),parathyroid hormone levels(r =- 0.256,P = 0.011),serum IL-6 levels(r =- 0.492,P = 0.000),serum hs-CRP levels(r =- 0.272,P = 0.006) and valvular calcification(r =- 0.600,P = 0.001).However,serum fetuin-A levels were positively correlated with serum albumin(r = 0.298,P = 0.003).Conclusions Cardiac valve calcification is prevalent in MHD patients,especially aortic valve calcificatioa Serum fetuin-A showed an important association with valvular calcification and inflammation in MHD patients.Assessment of both serum levels of fetuin-A and inflammation may be of value to identify those subjects at higher risk of development and progression of cardiovascular events especially cardiac calcification. |
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| ISSN: | 1671-2390 |