Cohort profile: The Swiss Transplant Cohort Study (STCS): A nationwide longitudinal cohort study of all solid organ recipients in Switzerland
Purpose The Swiss Transplant Cohort Study (STCS) is a prospective multicentre cohort study which started to actively enrol study participants in May 2008. It takes advantage of combining data from all transplant programmes in one unique system to perform comprehensive nationwide reporting and to pro...
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BMJ Publishing Group
2021-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/11/12/e051176.full |
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| author | Thomas Fehr Pierre-Yves Bochud Oriol Manuel Roger Lehmann Christoph Berger Klara Posfay-Barbe Frank Ruschitzka Manuel Pascual Michael Koller Heiner Bucher Thomas Schachtner Annalisa Berzigotti Christoph Hess Sylvie Ferrari-Lacraz Dominik Heim Sabina de Geest Jürg Steiger Simona Rossi Christian Garzoni Thierry Carrel Sabina De Geest Christian van Delden Beat Mullhaupt Nicolas Goossens Guido Beldi Uyen Huynh-Do Karine Hadaya Sophie De Seigneux Susanne Stampf Nicolas J Mueller Vanessa Banz Isabelle Binet Alexander Leichtle Stefan Schaub Patrizia Amico Andres Axel John-David Aubert Beckmann Sonja Ekaterine Berishvili Sanda Branca Emmanuelle Catana Olivier De Rougemont Michael Dickenmann Joëlle Lynn Dreifuss Michel Duchosal Nicola Franscini Paola Gasche Soccal Christophe Gaudet Déla Golshayan Jörg Halter Sven Hillinger Hans Hirsch Patricia Hirt Günther Hofbauer Franz Immer Mirjam Laager Bettina Laesser Christian Lovis Hans-Peter Marti Pierre Yves Martin Michele Martinelli Valérie McLin Katell Mellac Aurélia Merçay Karin Mettler Nicolas Mueller Antonia Müller Ulrike Müller-Arndt Mirjam Nägeli Graziano Oldani Juliane Rick Anne Rosselet Silvia Rothlin Urs Schanz Aurelia Schnyder Macé Schuurmans Thierry Sengstag Federico Simonetta Guido Stirniman Ueli Stürzinger Christian Van Delden Jean-Pierre Venetz Jean Villard Julien Vionnet Madeleine Wick Markus Wilhlem Patrick Yerly |
| author_facet | Thomas Fehr Pierre-Yves Bochud Oriol Manuel Roger Lehmann Christoph Berger Klara Posfay-Barbe Frank Ruschitzka Manuel Pascual Michael Koller Heiner Bucher Thomas Schachtner Annalisa Berzigotti Christoph Hess Sylvie Ferrari-Lacraz Dominik Heim Sabina de Geest Jürg Steiger Simona Rossi Christian Garzoni Thierry Carrel Sabina De Geest Christian van Delden Beat Mullhaupt Nicolas Goossens Guido Beldi Uyen Huynh-Do Karine Hadaya Sophie De Seigneux Susanne Stampf Nicolas J Mueller Vanessa Banz Isabelle Binet Alexander Leichtle Stefan Schaub Patrizia Amico Andres Axel John-David Aubert Beckmann Sonja Ekaterine Berishvili Sanda Branca Emmanuelle Catana Olivier De Rougemont Michael Dickenmann Joëlle Lynn Dreifuss Michel Duchosal Nicola Franscini Paola Gasche Soccal Christophe Gaudet Déla Golshayan Jörg Halter Sven Hillinger Hans Hirsch Patricia Hirt Günther Hofbauer Franz Immer Mirjam Laager Bettina Laesser Christian Lovis Hans-Peter Marti Pierre Yves Martin Michele Martinelli Valérie McLin Katell Mellac Aurélia Merçay Karin Mettler Nicolas Mueller Antonia Müller Ulrike Müller-Arndt Mirjam Nägeli Graziano Oldani Juliane Rick Anne Rosselet Silvia Rothlin Urs Schanz Aurelia Schnyder Macé Schuurmans Thierry Sengstag Federico Simonetta Guido Stirniman Ueli Stürzinger Christian Van Delden Jean-Pierre Venetz Jean Villard Julien Vionnet Madeleine Wick Markus Wilhlem Patrick Yerly |
| author_sort | Thomas Fehr |
| collection | DOAJ |
| description | Purpose The Swiss Transplant Cohort Study (STCS) is a prospective multicentre cohort study which started to actively enrol study participants in May 2008. It takes advantage of combining data from all transplant programmes in one unique system to perform comprehensive nationwide reporting and to promote translational and clinical post-transplant outcome research in the framework of Swiss transplantation medicine.Participants Over 5500 solid organ transplant recipients have been enrolled in all six Swiss transplant centres by end of 2019, around three-quarter of them for kidney and liver transplants. Ninety-three per cent of all transplanted recipients have consented to study participation, almost all of them (99%) contributed to bio-sampling. The STCS genomic data set includes around 3000 patients.Findings to date Detailed clinical and laboratory data in high granularity as well as patient-reported outcomes from transplant recipients and activities in Switzerland are available in the last decade. Interdisciplinary contributions in diverse fields of transplantation medicine such as infectious diseases, genomics, oncology, immunology and psychosocial science have resulted in approximately 70 scientific papers getting published in peer-review journals so far.Future plans The STCS will deepen its efforts in personalised medicine and digital epidemiology, and will also focus on allocation research and the use of causal inference methods to make complex matters in transplant medicine more understandable and transparent. |
| format | Article |
| id | doaj-art-8068d54c90ac4e529fcf8cdc6c453b03 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-8068d54c90ac4e529fcf8cdc6c453b032024-12-09T18:40:08ZengBMJ Publishing GroupBMJ Open2044-60552021-12-01111210.1136/bmjopen-2021-051176Cohort profile: The Swiss Transplant Cohort Study (STCS): A nationwide longitudinal cohort study of all solid organ recipients in SwitzerlandThomas Fehr0Pierre-Yves Bochud1Oriol Manuel2Roger Lehmann3Christoph Berger4Klara Posfay-BarbeFrank Ruschitzka5Manuel Pascual6Michael Koller7Heiner BucherThomas SchachtnerAnnalisa Berzigotti8Christoph HessSylvie Ferrari-LacrazDominik Heim9Sabina de Geest10Jürg Steiger11Simona RossiChristian GarzoniThierry CarrelSabina De GeestChristian van Delden12Beat MullhauptNicolas Goossens13Guido BeldiUyen Huynh-Do14Karine HadayaSophie De Seigneux15Susanne Stampf16Nicolas J Mueller17Vanessa Banz18Isabelle Binet19Alexander Leichtle20Stefan Schaub21Patrizia AmicoAndres AxelJohn-David AubertBeckmann SonjaEkaterine BerishviliSanda BrancaEmmanuelle CatanaOlivier De RougemontMichael DickenmannJoëlle Lynn DreifussMichel DuchosalNicola FransciniPaola Gasche SoccalChristophe GaudetDéla GolshayanJörg HalterSven HillingerHans HirschPatricia HirtGünther HofbauerFranz ImmerMirjam LaagerBettina LaesserChristian LovisHans-Peter MartiPierre Yves MartinMichele MartinelliValérie McLinKatell MellacAurélia MerçayKarin MettlerNicolas MuellerAntonia MüllerUlrike Müller-ArndtMirjam NägeliGraziano OldaniJuliane RickAnne RosseletSilvia RothlinUrs SchanzAurelia SchnyderMacé SchuurmansThierry SengstagFederico SimonettaGuido StirnimanUeli StürzingerChristian Van DeldenJean-Pierre VenetzJean Villard22Julien Vionnet23Madeleine WickMarkus WilhlemPatrick YerlyDepartment of Internal Medicine, Kantonsspital Graubünden, Chur, Graubünden, SwitzerlandService of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandTransplantation Center, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandEndokrinologie, Diabetologie und Klinische Ernährung, UniversitätsSpital Zürich, Zurich, Switzerland1University Children’s Hospital Zurich, Department of Infectious Diseases and Hospital Epidemiology, 8032 ZurichDepartment of Cardiology, University Heart Center, University Hospital Zurich, Zurich, SwitzerlandTransplantation Center, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandClinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, SwitzerlandDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland1 Division of Hematology, University Hospital, Basel, SwitzerlandDepartment of Public Health, Institute of Nursing Science, University of Basel, Basel, SwitzerlandClinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, SwitzerlandTransplant Infectious Diseases Unit, University Hospitals Geneva and Faculty of Medicine, Geneva, SwitzerlandDepartment of Gastroenterology and Hepatology, Geneva University Hospitals, Geneva, Switzerland8 Division of Nephrology and Hypertension, University Hospital Bern, Bern, SwitzerlandService of Nephrology, Department of Medicine, University Hospital of Geneva, Geneva, SwitzerlandClinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, SwitzerlandDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, SwitzerlandDepartment of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, SwitzerlandNephrology and Transplantation Medicine, Kantonsspital St Gallen, Sankt Gallen, SwitzerlandCenter for Laboratory Medicine, University Institute of Clinical Chemistry, Inselspital University Hospital Bern, Bern, SwitzerlandClinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, SwitzerlandUniversity Hospitals of Geneva, Geneva, SwitzerlandService of Gastroenterology and Hepatology, Lausanne University Hospital, Lausanne, SwitzerlandPurpose The Swiss Transplant Cohort Study (STCS) is a prospective multicentre cohort study which started to actively enrol study participants in May 2008. It takes advantage of combining data from all transplant programmes in one unique system to perform comprehensive nationwide reporting and to promote translational and clinical post-transplant outcome research in the framework of Swiss transplantation medicine.Participants Over 5500 solid organ transplant recipients have been enrolled in all six Swiss transplant centres by end of 2019, around three-quarter of them for kidney and liver transplants. Ninety-three per cent of all transplanted recipients have consented to study participation, almost all of them (99%) contributed to bio-sampling. The STCS genomic data set includes around 3000 patients.Findings to date Detailed clinical and laboratory data in high granularity as well as patient-reported outcomes from transplant recipients and activities in Switzerland are available in the last decade. Interdisciplinary contributions in diverse fields of transplantation medicine such as infectious diseases, genomics, oncology, immunology and psychosocial science have resulted in approximately 70 scientific papers getting published in peer-review journals so far.Future plans The STCS will deepen its efforts in personalised medicine and digital epidemiology, and will also focus on allocation research and the use of causal inference methods to make complex matters in transplant medicine more understandable and transparent.https://bmjopen.bmj.com/content/11/12/e051176.full |
| spellingShingle | Thomas Fehr Pierre-Yves Bochud Oriol Manuel Roger Lehmann Christoph Berger Klara Posfay-Barbe Frank Ruschitzka Manuel Pascual Michael Koller Heiner Bucher Thomas Schachtner Annalisa Berzigotti Christoph Hess Sylvie Ferrari-Lacraz Dominik Heim Sabina de Geest Jürg Steiger Simona Rossi Christian Garzoni Thierry Carrel Sabina De Geest Christian van Delden Beat Mullhaupt Nicolas Goossens Guido Beldi Uyen Huynh-Do Karine Hadaya Sophie De Seigneux Susanne Stampf Nicolas J Mueller Vanessa Banz Isabelle Binet Alexander Leichtle Stefan Schaub Patrizia Amico Andres Axel John-David Aubert Beckmann Sonja Ekaterine Berishvili Sanda Branca Emmanuelle Catana Olivier De Rougemont Michael Dickenmann Joëlle Lynn Dreifuss Michel Duchosal Nicola Franscini Paola Gasche Soccal Christophe Gaudet Déla Golshayan Jörg Halter Sven Hillinger Hans Hirsch Patricia Hirt Günther Hofbauer Franz Immer Mirjam Laager Bettina Laesser Christian Lovis Hans-Peter Marti Pierre Yves Martin Michele Martinelli Valérie McLin Katell Mellac Aurélia Merçay Karin Mettler Nicolas Mueller Antonia Müller Ulrike Müller-Arndt Mirjam Nägeli Graziano Oldani Juliane Rick Anne Rosselet Silvia Rothlin Urs Schanz Aurelia Schnyder Macé Schuurmans Thierry Sengstag Federico Simonetta Guido Stirniman Ueli Stürzinger Christian Van Delden Jean-Pierre Venetz Jean Villard Julien Vionnet Madeleine Wick Markus Wilhlem Patrick Yerly Cohort profile: The Swiss Transplant Cohort Study (STCS): A nationwide longitudinal cohort study of all solid organ recipients in Switzerland BMJ Open |
| title | Cohort profile: The Swiss Transplant Cohort Study (STCS): A nationwide longitudinal cohort study of all solid organ recipients in Switzerland |
| title_full | Cohort profile: The Swiss Transplant Cohort Study (STCS): A nationwide longitudinal cohort study of all solid organ recipients in Switzerland |
| title_fullStr | Cohort profile: The Swiss Transplant Cohort Study (STCS): A nationwide longitudinal cohort study of all solid organ recipients in Switzerland |
| title_full_unstemmed | Cohort profile: The Swiss Transplant Cohort Study (STCS): A nationwide longitudinal cohort study of all solid organ recipients in Switzerland |
| title_short | Cohort profile: The Swiss Transplant Cohort Study (STCS): A nationwide longitudinal cohort study of all solid organ recipients in Switzerland |
| title_sort | cohort profile the swiss transplant cohort study stcs a nationwide longitudinal cohort study of all solid organ recipients in switzerland |
| url | https://bmjopen.bmj.com/content/11/12/e051176.full |
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