In vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoforms.

In vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoforms.

Prion diseases are incurable neurodegenerative disorders in which the normal cellular prion protein (PrP(C)) converts into a misfolded isoform (PrP(Sc)) with unique biochemical and structural properties that correlate with disease. In humans, prion disorders, such as Creutzfeldt-Jakob disease, prese...

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Main Authors: Pedro Fernandez-Funez, Sergio Casas-Tinto, Yan Zhang, Melisa Gómez-Velazquez, Marco A Morales-Garza, Ana C Cepeda-Nieto, Joaquín Castilla, Claudio Soto, Diego E Rincon-Limas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-06-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000507&type=printable
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