Quantitative determination and antibacterial properties of TiO2 nanoparticle-doped glass ionomer cement: an in vitro study
Purpose: The aim of the present study is to determine the amount of titanium ions released into the artificial salivary medium by modified glass ionomer cement (GIC) doped with 3% and 5% (w/w) titanium dioxide nanoparticles (TiO2-NPs), and to evaluate their antibacterial properties.Materials and met...
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| Format: | Article |
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Istanbul University
2024-01-01
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| Series: | European Oral Research |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/07DA6F9791114A20A3F4BF16750BA692 |
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| author | Tivanani V D Mahendra Tavva Santhosh Rahul Santosh Venkata Ramesh Konathala P Swetha V Sai Sai Keerthi Vyshnavi M |
| author_facet | Tivanani V D Mahendra Tavva Santhosh Rahul Santosh Venkata Ramesh Konathala P Swetha V Sai Sai Keerthi Vyshnavi M |
| author_sort | Tivanani V D Mahendra |
| collection | DOAJ |
| description | Purpose: The aim of the present study is to determine the amount of titanium ions released into the artificial salivary medium by modified glass ionomer cement (GIC) doped with 3% and 5% (w/w) titanium dioxide nanoparticles (TiO2-NPs), and to evaluate their antibacterial properties.Materials and methods: 120 cylindrical discs with a diameter of 4 mm and a height of 6 mm were made with 3% and 5% w/w modified GIC containing TiO2 NPs, divided into two groups of 60, and immersed in a chemically synthesized salivary medium. The samples were quantified over four-time periods: 24 hours, two months, four months, and six months, using inductively coupled plasma mass spectroscopy (ICP-MS), antibacterial properties were evaluated by means of colony forming count (CFU) method.Results: The amount of titanium ions released from the discs that received 3%(w/w) TiO2 was highest in the first two months, with no significant release at successive intervals. Also, the second group, which included 5% (w/w) TiO2, saw a considerable ion release at every interval, with the second month seeing the maximum release. The levels in the 5% (w/w) group were consistently higher when the two concentrations were compared at each of the four time points, indicating a considerable increase in titanium release and antibacterial property with a concentration increase from 3% to 5%.Conclusion: 3% and 5% (w/w) concentrations may be considered safe and exhibit significant antimicrobial effect, titanium ions were discharged at higher rates in 5% (w/w) modified GIC containing TiO2-NPs than in 3% (w/w) modified GIC containing TiO2-NPs. |
| format | Article |
| id | doaj-art-805a25f00c9d4bbbb7c85937c580c4e5 |
| institution | Kabale University |
| issn | 2651-2823 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Istanbul University |
| record_format | Article |
| series | European Oral Research |
| spelling | doaj-art-805a25f00c9d4bbbb7c85937c580c4e52025-08-20T03:48:42ZengIstanbul UniversityEuropean Oral Research2651-28232024-01-0158181310.26650/eor.20231225662123456Quantitative determination and antibacterial properties of TiO2 nanoparticle-doped glass ionomer cement: an in vitro studyTivanani V D Mahendra0https://orcid.org/0000-0002-1905-3511Tavva Santhosh Rahulhttps://orcid.org/0000-0002-6860-7381Santosh Venkata Ramesh Konathala1https://orcid.org/0000-0001-7022-0023P Swetha2https://orcid.org/0000-0001-7561-5630V Sai Sai Keerthi3https://orcid.org/0000-0001-5922-4832Vyshnavi M4https://orcid.org/0000-0002-0705-3610Vishnu Dental College, Bhimavaram, IndiaVishnu Dental College, Bhimavaram, IndiaVishnu Dental College, Bhimavaram, IndiaVishnu Dental College, Bhimavaram, IndiaPrivate Practice, Istanbul, TurkiyePurpose: The aim of the present study is to determine the amount of titanium ions released into the artificial salivary medium by modified glass ionomer cement (GIC) doped with 3% and 5% (w/w) titanium dioxide nanoparticles (TiO2-NPs), and to evaluate their antibacterial properties.Materials and methods: 120 cylindrical discs with a diameter of 4 mm and a height of 6 mm were made with 3% and 5% w/w modified GIC containing TiO2 NPs, divided into two groups of 60, and immersed in a chemically synthesized salivary medium. The samples were quantified over four-time periods: 24 hours, two months, four months, and six months, using inductively coupled plasma mass spectroscopy (ICP-MS), antibacterial properties were evaluated by means of colony forming count (CFU) method.Results: The amount of titanium ions released from the discs that received 3%(w/w) TiO2 was highest in the first two months, with no significant release at successive intervals. Also, the second group, which included 5% (w/w) TiO2, saw a considerable ion release at every interval, with the second month seeing the maximum release. The levels in the 5% (w/w) group were consistently higher when the two concentrations were compared at each of the four time points, indicating a considerable increase in titanium release and antibacterial property with a concentration increase from 3% to 5%.Conclusion: 3% and 5% (w/w) concentrations may be considered safe and exhibit significant antimicrobial effect, titanium ions were discharged at higher rates in 5% (w/w) modified GIC containing TiO2-NPs than in 3% (w/w) modified GIC containing TiO2-NPs.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/07DA6F9791114A20A3F4BF16750BA692antibacterialglass ionomer cemention releasesalivatitanium dioxide. |
| spellingShingle | Tivanani V D Mahendra Tavva Santhosh Rahul Santosh Venkata Ramesh Konathala P Swetha V Sai Sai Keerthi Vyshnavi M Quantitative determination and antibacterial properties of TiO2 nanoparticle-doped glass ionomer cement: an in vitro study European Oral Research antibacterial glass ionomer cement ion release saliva titanium dioxide. |
| title | Quantitative determination and antibacterial properties of TiO2 nanoparticle-doped glass ionomer cement: an in vitro study |
| title_full | Quantitative determination and antibacterial properties of TiO2 nanoparticle-doped glass ionomer cement: an in vitro study |
| title_fullStr | Quantitative determination and antibacterial properties of TiO2 nanoparticle-doped glass ionomer cement: an in vitro study |
| title_full_unstemmed | Quantitative determination and antibacterial properties of TiO2 nanoparticle-doped glass ionomer cement: an in vitro study |
| title_short | Quantitative determination and antibacterial properties of TiO2 nanoparticle-doped glass ionomer cement: an in vitro study |
| title_sort | quantitative determination and antibacterial properties of tio2 nanoparticle doped glass ionomer cement an in vitro study |
| topic | antibacterial glass ionomer cement ion release saliva titanium dioxide. |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/07DA6F9791114A20A3F4BF16750BA692 |
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