Normative Values of Retinal Nerve Fibre Layer Thickness and Optic Nerve Head Parameters and Their Association with Visual Function in an African Population
Purpose. To determine normative values of retinal nerve fibre layer thickness (RNFL) and optic nerve head (ONH) parameters and their association with routine clinical tests such as refractive error (RE), stereoacuity (SA), and contrast sensitivity (CS) in an African population. Methods. In a cross-s...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2020/7150673 |
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| author | Stephen Ocansey Emmanuel Kwasi Abu Andrew Owusu-Ansah Shadrack Mensah John Oduro-Boateng Rene Abalo Kojo Samuel Kyei Samuel Bert Boadi-Kusi Obed Amoah-Smith Enyam Komla Amewuho Morny Charles Darko-Takyi Carl Halladay Abraham Benjamin Appiah Nyamekye Alex Azuka Ilechie |
| author_facet | Stephen Ocansey Emmanuel Kwasi Abu Andrew Owusu-Ansah Shadrack Mensah John Oduro-Boateng Rene Abalo Kojo Samuel Kyei Samuel Bert Boadi-Kusi Obed Amoah-Smith Enyam Komla Amewuho Morny Charles Darko-Takyi Carl Halladay Abraham Benjamin Appiah Nyamekye Alex Azuka Ilechie |
| author_sort | Stephen Ocansey |
| collection | DOAJ |
| description | Purpose. To determine normative values of retinal nerve fibre layer thickness (RNFL) and optic nerve head (ONH) parameters and their association with routine clinical tests such as refractive error (RE), stereoacuity (SA), and contrast sensitivity (CS) in an African population. Methods. In a cross-sectional observational study, 100 normal subjects aged 20 to 78 years were evaluated using the Cirrus HD-OCT 5000 and matched with 200 glaucoma patients. Results. Average (±SD) RNFL thickness for normal subjects was found to be 102.37 ± 7.45 (range, 82–119 microns) compared with 90.74 ± 14.50 found for glaucoma subjects. Females had higher average RNFL values (104.84 ± 6.90) compared with males (99.80 ± 7.18). Significant associations were calculated between quadrant RNFL thickness and SA, SE, and CS (all p<0.05). The mean cup to disc ratio (CDR) was 0.49 ± 0.12, and mean optic disc area (DA) was 2.08 mm2 ± 0.40. Smaller DA was recorded for participants aged 60+ years (1.86 ± 0.25), followed by 40–59 age group (2.01 ± 0.41) and then 20–39 age group (2.19 ± 0.41). Significant associations were calculated between SA and ONH parameters, except rim area (all p<0.01), and RE was significantly associated with DA and average CDR (all p<0.05). Conclusion. RNFL thickness in healthy black Ghanaian population was significantly higher than that reported in other races. The values and associations reported in this study can inform clinical decision on the normal variation in RNFL and optic disc parameters. |
| format | Article |
| id | doaj-art-80583336535a40a2bd45434632f90ce2 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-80583336535a40a2bd45434632f90ce22025-08-20T03:35:14ZengWileyJournal of Ophthalmology2090-004X2090-00582020-01-01202010.1155/2020/71506737150673Normative Values of Retinal Nerve Fibre Layer Thickness and Optic Nerve Head Parameters and Their Association with Visual Function in an African PopulationStephen Ocansey0Emmanuel Kwasi Abu1Andrew Owusu-Ansah2Shadrack Mensah3John Oduro-Boateng4Rene Abalo Kojo5Samuel Kyei6Samuel Bert Boadi-Kusi7Obed Amoah-Smith8Enyam Komla Amewuho Morny9Charles Darko-Takyi10Carl Halladay Abraham11Benjamin Appiah Nyamekye12Alex Azuka Ilechie13Department of Optometry, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, GhanaDepartment of Optometry, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, GhanaDepartment of Optometry, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, GhanaEye Unit, Nsawam Government Hospital, Nsawam, Eastern Region, GhanaEmmanuel Eye Medical Centre, Adamfio Link East Legon, Accra, GhanaEmmanuel Eye Medical Centre, Adamfio Link East Legon, Accra, GhanaDepartment of Optometry, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, GhanaDepartment of Optometry, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, GhanaEye Unit, Directorate of University Health Services, University of Cape Coast Hospital, Cape Coast, GhanaDepartment of Optometry, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, GhanaDepartment of Optometry, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, GhanaDepartment of Optometry, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, GhanaEmmanuel Eye Medical Centre, Adamfio Link East Legon, Accra, GhanaDepartment of Optometry, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, GhanaPurpose. To determine normative values of retinal nerve fibre layer thickness (RNFL) and optic nerve head (ONH) parameters and their association with routine clinical tests such as refractive error (RE), stereoacuity (SA), and contrast sensitivity (CS) in an African population. Methods. In a cross-sectional observational study, 100 normal subjects aged 20 to 78 years were evaluated using the Cirrus HD-OCT 5000 and matched with 200 glaucoma patients. Results. Average (±SD) RNFL thickness for normal subjects was found to be 102.37 ± 7.45 (range, 82–119 microns) compared with 90.74 ± 14.50 found for glaucoma subjects. Females had higher average RNFL values (104.84 ± 6.90) compared with males (99.80 ± 7.18). Significant associations were calculated between quadrant RNFL thickness and SA, SE, and CS (all p<0.05). The mean cup to disc ratio (CDR) was 0.49 ± 0.12, and mean optic disc area (DA) was 2.08 mm2 ± 0.40. Smaller DA was recorded for participants aged 60+ years (1.86 ± 0.25), followed by 40–59 age group (2.01 ± 0.41) and then 20–39 age group (2.19 ± 0.41). Significant associations were calculated between SA and ONH parameters, except rim area (all p<0.01), and RE was significantly associated with DA and average CDR (all p<0.05). Conclusion. RNFL thickness in healthy black Ghanaian population was significantly higher than that reported in other races. The values and associations reported in this study can inform clinical decision on the normal variation in RNFL and optic disc parameters.http://dx.doi.org/10.1155/2020/7150673 |
| spellingShingle | Stephen Ocansey Emmanuel Kwasi Abu Andrew Owusu-Ansah Shadrack Mensah John Oduro-Boateng Rene Abalo Kojo Samuel Kyei Samuel Bert Boadi-Kusi Obed Amoah-Smith Enyam Komla Amewuho Morny Charles Darko-Takyi Carl Halladay Abraham Benjamin Appiah Nyamekye Alex Azuka Ilechie Normative Values of Retinal Nerve Fibre Layer Thickness and Optic Nerve Head Parameters and Their Association with Visual Function in an African Population Journal of Ophthalmology |
| title | Normative Values of Retinal Nerve Fibre Layer Thickness and Optic Nerve Head Parameters and Their Association with Visual Function in an African Population |
| title_full | Normative Values of Retinal Nerve Fibre Layer Thickness and Optic Nerve Head Parameters and Their Association with Visual Function in an African Population |
| title_fullStr | Normative Values of Retinal Nerve Fibre Layer Thickness and Optic Nerve Head Parameters and Their Association with Visual Function in an African Population |
| title_full_unstemmed | Normative Values of Retinal Nerve Fibre Layer Thickness and Optic Nerve Head Parameters and Their Association with Visual Function in an African Population |
| title_short | Normative Values of Retinal Nerve Fibre Layer Thickness and Optic Nerve Head Parameters and Their Association with Visual Function in an African Population |
| title_sort | normative values of retinal nerve fibre layer thickness and optic nerve head parameters and their association with visual function in an african population |
| url | http://dx.doi.org/10.1155/2020/7150673 |
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