The Contribution of Neutrophil Extracellular Traps to Coagulopathy in Patients with COVID-19-Related Thrombosis
COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is associated with hypercoagulability and increased incidence of thrombotic events. In this study, we investigated the levels of neutrophil extracellular trap biomarkers and von Willebrand factor to assess if thes...
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MDPI AG
2024-10-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/16/11/1677 |
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| author | Carolyn Enochs Gabriela Delevati Colpo Lucy Couture Lynae Baskin Ana E. Cahuiche Eunyoung Angela Lee Shahid Nimjee Louise D. McCullough |
| author_facet | Carolyn Enochs Gabriela Delevati Colpo Lucy Couture Lynae Baskin Ana E. Cahuiche Eunyoung Angela Lee Shahid Nimjee Louise D. McCullough |
| author_sort | Carolyn Enochs |
| collection | DOAJ |
| description | COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is associated with hypercoagulability and increased incidence of thrombotic events. In this study, we investigated the levels of neutrophil extracellular trap biomarkers and von Willebrand factor to assess if these could predict the occurrence of a thrombotic event in COVID-19 patients. We enrolled 202 patients hospitalized with symptomatic COVID-19 infection. Of those, 104 patients did not experience any type of thrombotic events before or during their hospitalization. These patients were compared to the other cohort of 98, who experienced thrombotic events before or during their hospitalization. In total, 61 patients who experienced thrombotic events had the event after initial blood collection, so the predictive capacity of biomarkers in these patients was evaluated. Citrullinated histone H3 was the best predictive biomarker for thrombotic events in COVID-19 regardless of age, sex, and race; disease severity was also a significant predictor in most thrombotic event groups. These results may better inform treatment and prophylaxis of thrombotic events in COVID-19 and similar viral illnesses in the future to improve outcomes and reduce mortality. |
| format | Article |
| id | doaj-art-804e568c90fe4ef1bdc10fb66dbdb0ea |
| institution | OA Journals |
| issn | 1999-4915 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-804e568c90fe4ef1bdc10fb66dbdb0ea2025-08-20T01:54:04ZengMDPI AGViruses1999-49152024-10-011611167710.3390/v16111677The Contribution of Neutrophil Extracellular Traps to Coagulopathy in Patients with COVID-19-Related ThrombosisCarolyn Enochs0Gabriela Delevati Colpo1Lucy Couture2Lynae Baskin3Ana E. Cahuiche4Eunyoung Angela Lee5Shahid Nimjee6Louise D. McCullough7Department of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USADepartment of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USADepartment of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USADepartment of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USADepartment of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USADepartment of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USANeurosurgery, The Ohio State University Medical Center, Columbus, OH 43210, USADepartment of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USACOVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is associated with hypercoagulability and increased incidence of thrombotic events. In this study, we investigated the levels of neutrophil extracellular trap biomarkers and von Willebrand factor to assess if these could predict the occurrence of a thrombotic event in COVID-19 patients. We enrolled 202 patients hospitalized with symptomatic COVID-19 infection. Of those, 104 patients did not experience any type of thrombotic events before or during their hospitalization. These patients were compared to the other cohort of 98, who experienced thrombotic events before or during their hospitalization. In total, 61 patients who experienced thrombotic events had the event after initial blood collection, so the predictive capacity of biomarkers in these patients was evaluated. Citrullinated histone H3 was the best predictive biomarker for thrombotic events in COVID-19 regardless of age, sex, and race; disease severity was also a significant predictor in most thrombotic event groups. These results may better inform treatment and prophylaxis of thrombotic events in COVID-19 and similar viral illnesses in the future to improve outcomes and reduce mortality.https://www.mdpi.com/1999-4915/16/11/1677coronavirusCOVID-19thrombosisviral infectionepidemiologycoagulation |
| spellingShingle | Carolyn Enochs Gabriela Delevati Colpo Lucy Couture Lynae Baskin Ana E. Cahuiche Eunyoung Angela Lee Shahid Nimjee Louise D. McCullough The Contribution of Neutrophil Extracellular Traps to Coagulopathy in Patients with COVID-19-Related Thrombosis Viruses coronavirus COVID-19 thrombosis viral infection epidemiology coagulation |
| title | The Contribution of Neutrophil Extracellular Traps to Coagulopathy in Patients with COVID-19-Related Thrombosis |
| title_full | The Contribution of Neutrophil Extracellular Traps to Coagulopathy in Patients with COVID-19-Related Thrombosis |
| title_fullStr | The Contribution of Neutrophil Extracellular Traps to Coagulopathy in Patients with COVID-19-Related Thrombosis |
| title_full_unstemmed | The Contribution of Neutrophil Extracellular Traps to Coagulopathy in Patients with COVID-19-Related Thrombosis |
| title_short | The Contribution of Neutrophil Extracellular Traps to Coagulopathy in Patients with COVID-19-Related Thrombosis |
| title_sort | contribution of neutrophil extracellular traps to coagulopathy in patients with covid 19 related thrombosis |
| topic | coronavirus COVID-19 thrombosis viral infection epidemiology coagulation |
| url | https://www.mdpi.com/1999-4915/16/11/1677 |
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