The effect of Rosmarinus officinalis L infusion supplementation on blood pressure among healthy volunteers and grade 1 hypertensive patients
Background: Rosmarinus officinalis L, has been traditionally used to manage various ailments. Preclinical trials have reported the antihypertensive effect of the bioactive compounds in rosemary. However, clinical studies on its effects on hypertension are lacking. Objective: This study aimed to expl...
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Elsevier
2025-05-01
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| Series: | Phytomedicine Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031325000569 |
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| author | Awatef Sassi Aicha Laouani Mohamed Aymen Ben Abdessalem Imen Jarray Hana Nasrallah Farhana Ferdousi Manel Nouira Ali Mtiraoui Abdallah Mahdhaoui Hiroko Isoda Saad Saguem |
| author_facet | Awatef Sassi Aicha Laouani Mohamed Aymen Ben Abdessalem Imen Jarray Hana Nasrallah Farhana Ferdousi Manel Nouira Ali Mtiraoui Abdallah Mahdhaoui Hiroko Isoda Saad Saguem |
| author_sort | Awatef Sassi |
| collection | DOAJ |
| description | Background: Rosmarinus officinalis L, has been traditionally used to manage various ailments. Preclinical trials have reported the antihypertensive effect of the bioactive compounds in rosemary. However, clinical studies on its effects on hypertension are lacking. Objective: This study aimed to explore the efficacy, safety, and tolerability of a 45-day administration of rosemary infusion in both healthy participants and individuals with grade 1 hypertension. Methods: A total of 18 healthy subjects and 35 grade 1 hypertensive patients were enrolled and instructed to consume a daily infusion prepared by steeping 2 g of powdered rosemary leaves in 100 ml of boiled water. The study was completed by 15 healthy participants and 30 hypertensive patients. Baseline and post-intervention clinical and biochemical parameters, such as systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP), heart rate (HR), and pulse pressure (PP), were measured using ambulatory blood pressure monitoring (MBP). Results: In the hypertensive group, rosemary infusion consumption over 45 days led to a significant reduction in 24-h SBP (P = 0.005), DBP (P = 0.003), daytime SBP and DBP (P = 0.003 and P = 0.002, respectively), MBP (P = 0.003), and Nocturnal SBP dipping (P = 0.04). In contrast, no significant changes in SBP or DBP were observed among healthy participants. Biochemical safety assessments showed no significant differences between baseline and post-intervention values for both groups. Additionally, no adverse effects were reported, further supporting the safety and efficacy of rosemary infusion. Conclusion: This preliminary trial allowed the exploration of the effectiveness of rosemary infusion in reducing SBP and DBP in hypertensive patients with grade 1 hypertension over a 45-day period. |
| format | Article |
| id | doaj-art-804b8aaa11914b808cc536e58006d73d |
| institution | Kabale University |
| issn | 2667-0313 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj-art-804b8aaa11914b808cc536e58006d73d2025-08-20T03:53:13ZengElsevierPhytomedicine Plus2667-03132025-05-015210078310.1016/j.phyplu.2025.100783The effect of Rosmarinus officinalis L infusion supplementation on blood pressure among healthy volunteers and grade 1 hypertensive patientsAwatef Sassi0Aicha Laouani1Mohamed Aymen Ben Abdessalem2Imen Jarray3Hana Nasrallah4Farhana Ferdousi5Manel Nouira6Ali Mtiraoui7Abdallah Mahdhaoui8Hiroko Isoda9Saad Saguem10Research Laboratory LR14ES05, Faculty of Medicine, University of Sousse, Tunisia; USCR Analytical Platform UHPLC-MS & Research in Medicine and Biology, Faculty of Medicine, University of Sousse, Sousse 4002, TunisiaLaboratory of Metabolic Biophysics and Applied Pharmacology, Faculty of Medicine, University of Sousse, Sousse 4002, Tunisia; USCR Analytical Platform UHPLC-MS & Research in Medicine and Biology, Faculty of Medicine, University of Sousse, Sousse 4002, TunisiaResearch Laboratory LR14ES05, Faculty of Medicine, University of Sousse, Tunisia; Cardiology Department, Farhat Hached Hospital, Sousse, TunisiaRegional Blood Transfusion Centre, Farhat Hached Hospital, Sousse, TunisiaLaboratory of Metabolic Biophysics and Applied Pharmacology, Faculty of Medicine, University of Sousse, Sousse 4002, Tunisia; USCR Analytical Platform UHPLC-MS & Research in Medicine and Biology, Faculty of Medicine, University of Sousse, Sousse 4002, TunisiaInstitute of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Alliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, Tsukuba, Ibaraki 305-8572, JapanLaboratory of Metabolic Biophysics and Applied Pharmacology, Faculty of Medicine, University of Sousse, Sousse 4002, Tunisia; USCR Analytical Platform UHPLC-MS & Research in Medicine and Biology, Faculty of Medicine, University of Sousse, Sousse 4002, TunisiaResearch Laboratory (LR12ES03), Department of Family and Community Medicine, Faculty of Medicine of Sousse, University of Sousse, Avenue Mohamed Karoui, 4002 Sousse, TunisiaResearch Laboratory LR14ES05, Faculty of Medicine, University of Sousse, Tunisia; Cardiology Department, Farhat Hached Hospital, Sousse, TunisiaInstitute of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Alliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan; Open Innovation Laboratory for Food and Medicinal Resource Engineering (FoodMed-OIL), University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan; Corresponding author at: Institute of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.Laboratory of Metabolic Biophysics and Applied Pharmacology, Faculty of Medicine, University of Sousse, Sousse 4002, Tunisia; USCR Analytical Platform UHPLC-MS & Research in Medicine and Biology, Faculty of Medicine, University of Sousse, Sousse 4002, Tunisia; Corresponding author at: Laboratory of Metabolic Biophysics and Applied Pharmacology, Faculty of Medicine, University of Sousse, Sousse 4002, TunisiaBackground: Rosmarinus officinalis L, has been traditionally used to manage various ailments. Preclinical trials have reported the antihypertensive effect of the bioactive compounds in rosemary. However, clinical studies on its effects on hypertension are lacking. Objective: This study aimed to explore the efficacy, safety, and tolerability of a 45-day administration of rosemary infusion in both healthy participants and individuals with grade 1 hypertension. Methods: A total of 18 healthy subjects and 35 grade 1 hypertensive patients were enrolled and instructed to consume a daily infusion prepared by steeping 2 g of powdered rosemary leaves in 100 ml of boiled water. The study was completed by 15 healthy participants and 30 hypertensive patients. Baseline and post-intervention clinical and biochemical parameters, such as systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP), heart rate (HR), and pulse pressure (PP), were measured using ambulatory blood pressure monitoring (MBP). Results: In the hypertensive group, rosemary infusion consumption over 45 days led to a significant reduction in 24-h SBP (P = 0.005), DBP (P = 0.003), daytime SBP and DBP (P = 0.003 and P = 0.002, respectively), MBP (P = 0.003), and Nocturnal SBP dipping (P = 0.04). In contrast, no significant changes in SBP or DBP were observed among healthy participants. Biochemical safety assessments showed no significant differences between baseline and post-intervention values for both groups. Additionally, no adverse effects were reported, further supporting the safety and efficacy of rosemary infusion. Conclusion: This preliminary trial allowed the exploration of the effectiveness of rosemary infusion in reducing SBP and DBP in hypertensive patients with grade 1 hypertension over a 45-day period.http://www.sciencedirect.com/science/article/pii/S2667031325000569Rosmarinus officinalis L infusionBlood pressureHypertension grade 1 |
| spellingShingle | Awatef Sassi Aicha Laouani Mohamed Aymen Ben Abdessalem Imen Jarray Hana Nasrallah Farhana Ferdousi Manel Nouira Ali Mtiraoui Abdallah Mahdhaoui Hiroko Isoda Saad Saguem The effect of Rosmarinus officinalis L infusion supplementation on blood pressure among healthy volunteers and grade 1 hypertensive patients Phytomedicine Plus Rosmarinus officinalis L infusion Blood pressure Hypertension grade 1 |
| title | The effect of Rosmarinus officinalis L infusion supplementation on blood pressure among healthy volunteers and grade 1 hypertensive patients |
| title_full | The effect of Rosmarinus officinalis L infusion supplementation on blood pressure among healthy volunteers and grade 1 hypertensive patients |
| title_fullStr | The effect of Rosmarinus officinalis L infusion supplementation on blood pressure among healthy volunteers and grade 1 hypertensive patients |
| title_full_unstemmed | The effect of Rosmarinus officinalis L infusion supplementation on blood pressure among healthy volunteers and grade 1 hypertensive patients |
| title_short | The effect of Rosmarinus officinalis L infusion supplementation on blood pressure among healthy volunteers and grade 1 hypertensive patients |
| title_sort | effect of rosmarinus officinalis l infusion supplementation on blood pressure among healthy volunteers and grade 1 hypertensive patients |
| topic | Rosmarinus officinalis L infusion Blood pressure Hypertension grade 1 |
| url | http://www.sciencedirect.com/science/article/pii/S2667031325000569 |
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