Pregnancy Outcome after Varenicline Exposure in the First Trimester
To the best of our knowledge this is the first case report describing exposure to varenicline, an α4β2 nicotinic acetylcholine partial receptor agonist used for smoking cessation therapy in pregnancy. A 29-year-old multiparous woman with an unplanned pregnancy has used varenicline 2 mg/day unintent...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2014/263981 |
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| author | Yusuf Cem Kaplan Nihal Olgac Dündar Burcu Kasap Barıs Karadas |
| author_facet | Yusuf Cem Kaplan Nihal Olgac Dündar Burcu Kasap Barıs Karadas |
| author_sort | Yusuf Cem Kaplan |
| collection | DOAJ |
| description | To the best of our knowledge this is the first case report describing exposure to varenicline, an α4β2 nicotinic acetylcholine partial receptor agonist used for smoking cessation therapy in pregnancy. A 29-year-old multiparous woman with an unplanned pregnancy has used varenicline 2 mg/day unintentionally yet regularly 4 weeks from her last menstrual period. Fetal ultrasound performed at each trimester, detailed anomaly scan, and fetal echocardiography which were performed at the 22nd gestational week showed normal fetal growth with no malformations. The patient delivered a healthy baby at the 38th week of gestation with normal Apgar score and physical examination findings. Age-appropriate physical and neurological development of the child has been observed for 6 months. Although it is not possible to draw definitive conclusions, this case report may contribute to the current available limited data regarding the safety of varenicline use in pregnancy. |
| format | Article |
| id | doaj-art-80481b820a7649fab86d39e0b4d69f8d |
| institution | Kabale University |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-80481b820a7649fab86d39e0b4d69f8d2025-02-03T01:32:09ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922014-01-01201410.1155/2014/263981263981Pregnancy Outcome after Varenicline Exposure in the First TrimesterYusuf Cem Kaplan0Nihal Olgac Dündar1Burcu Kasap2Barıs Karadas3Department of Pharmacology, Teratology Information Service, Faculty of Medicine, Izmir Katip Celebi University, 35280 Izmir, TurkeyDepartment of Pediatric Neurology, Faculty of Medicine, Izmir Katip Celebi University, 35280 Izmir, TurkeyDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Mugla Sitki Kocman University, 48000 Mugla, TurkeyDepartment of Pharmacology, Teratology Information Service, Faculty of Medicine, Izmir Katip Celebi University, 35280 Izmir, TurkeyTo the best of our knowledge this is the first case report describing exposure to varenicline, an α4β2 nicotinic acetylcholine partial receptor agonist used for smoking cessation therapy in pregnancy. A 29-year-old multiparous woman with an unplanned pregnancy has used varenicline 2 mg/day unintentionally yet regularly 4 weeks from her last menstrual period. Fetal ultrasound performed at each trimester, detailed anomaly scan, and fetal echocardiography which were performed at the 22nd gestational week showed normal fetal growth with no malformations. The patient delivered a healthy baby at the 38th week of gestation with normal Apgar score and physical examination findings. Age-appropriate physical and neurological development of the child has been observed for 6 months. Although it is not possible to draw definitive conclusions, this case report may contribute to the current available limited data regarding the safety of varenicline use in pregnancy.http://dx.doi.org/10.1155/2014/263981 |
| spellingShingle | Yusuf Cem Kaplan Nihal Olgac Dündar Burcu Kasap Barıs Karadas Pregnancy Outcome after Varenicline Exposure in the First Trimester Case Reports in Obstetrics and Gynecology |
| title | Pregnancy Outcome after Varenicline Exposure in the First Trimester |
| title_full | Pregnancy Outcome after Varenicline Exposure in the First Trimester |
| title_fullStr | Pregnancy Outcome after Varenicline Exposure in the First Trimester |
| title_full_unstemmed | Pregnancy Outcome after Varenicline Exposure in the First Trimester |
| title_short | Pregnancy Outcome after Varenicline Exposure in the First Trimester |
| title_sort | pregnancy outcome after varenicline exposure in the first trimester |
| url | http://dx.doi.org/10.1155/2014/263981 |
| work_keys_str_mv | AT yusufcemkaplan pregnancyoutcomeaftervareniclineexposureinthefirsttrimester AT nihalolgacdundar pregnancyoutcomeaftervareniclineexposureinthefirsttrimester AT burcukasap pregnancyoutcomeaftervareniclineexposureinthefirsttrimester AT barıskaradas pregnancyoutcomeaftervareniclineexposureinthefirsttrimester |