Modulating light level patterns reduces rest/activity disruption associated with shiftwork
Abstract Long-term exposure to nonstandard work schedules can result in circadian misalignment, which has been linked to a series of maladies. To test whether modulating light patterns reduces shiftwork-induced rest/activity disruptions, 30 male C57BL/6 J mice individually housed in cages outfitted...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | npj Biological Timing and Sleep |
| Online Access: | https://doi.org/10.1038/s44323-025-00043-3 |
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| author | Varun Mandi Haley Miller Jeongkyung Lee Young-Hwa Goo Mousumi Moulik Ke Ma Antoni Paul Vijay K. Yechoor Mariana G. Figueiro |
| author_facet | Varun Mandi Haley Miller Jeongkyung Lee Young-Hwa Goo Mousumi Moulik Ke Ma Antoni Paul Vijay K. Yechoor Mariana G. Figueiro |
| author_sort | Varun Mandi |
| collection | DOAJ |
| description | Abstract Long-term exposure to nonstandard work schedules can result in circadian misalignment, which has been linked to a series of maladies. To test whether modulating light patterns reduces shiftwork-induced rest/activity disruptions, 30 male C57BL/6 J mice individually housed in cages outfitted with running wheels were exposed to 6 simulated shiftwork light interventions. Mice experiencing high light levels during shiftwork exhibited a significant decrease in activity compared to low light levels during shiftwork and a conventional 12 L:12D condition, indicating circadian misalignment. In contrast, mice experiencing shiftwork in darkness combined with either modulated evening light pulses or circadian blind, vision-permissive light showed similar levels of rest/activity compared to a 12 L:12D condition, with phasor analysis indicating that their 24-h circadian rest/activity patterns were not misaligned. The results show that exposure to light that permits visibility but is below activation of the circadian system during shiftwork can prevent circadian misalignment. |
| format | Article |
| id | doaj-art-80472bd820d74b3ea87dab685cf80484 |
| institution | Kabale University |
| issn | 2948-281X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biological Timing and Sleep |
| spelling | doaj-art-80472bd820d74b3ea87dab685cf804842025-08-20T04:01:36ZengNature Portfolionpj Biological Timing and Sleep2948-281X2025-07-01211910.1038/s44323-025-00043-3Modulating light level patterns reduces rest/activity disruption associated with shiftworkVarun Mandi0Haley Miller1Jeongkyung Lee2Young-Hwa Goo3Mousumi Moulik4Ke Ma5Antoni Paul6Vijay K. Yechoor7Mariana G. Figueiro8Division of Endocrinology and Metabolism, Diabetes and Beta Cell Biology Center, Department of Medicine, University of PittsburghLight and Health Research Center, Department of Population Health Science and Policy, Icahn School of Medicine at Mount SinaiDivision of Endocrinology and Metabolism, Diabetes and Beta Cell Biology Center, Department of Medicine, University of PittsburghDepartment of Molecular and Cellular Physiology, Albany Medical CollegeDivision of Cardiology, Department of Pediatrics, Children’s Hospital of Pittsburgh, University of PittsburghDepartment of Diabetes Complications & Metabolism, Beckman Research Institute of City of HopeDepartment of Molecular and Cellular Physiology, Albany Medical CollegeDivision of Endocrinology and Metabolism, Diabetes and Beta Cell Biology Center, Department of Medicine, University of PittsburghLight and Health Research Center, Department of Population Health Science and Policy, Icahn School of Medicine at Mount SinaiAbstract Long-term exposure to nonstandard work schedules can result in circadian misalignment, which has been linked to a series of maladies. To test whether modulating light patterns reduces shiftwork-induced rest/activity disruptions, 30 male C57BL/6 J mice individually housed in cages outfitted with running wheels were exposed to 6 simulated shiftwork light interventions. Mice experiencing high light levels during shiftwork exhibited a significant decrease in activity compared to low light levels during shiftwork and a conventional 12 L:12D condition, indicating circadian misalignment. In contrast, mice experiencing shiftwork in darkness combined with either modulated evening light pulses or circadian blind, vision-permissive light showed similar levels of rest/activity compared to a 12 L:12D condition, with phasor analysis indicating that their 24-h circadian rest/activity patterns were not misaligned. The results show that exposure to light that permits visibility but is below activation of the circadian system during shiftwork can prevent circadian misalignment.https://doi.org/10.1038/s44323-025-00043-3 |
| spellingShingle | Varun Mandi Haley Miller Jeongkyung Lee Young-Hwa Goo Mousumi Moulik Ke Ma Antoni Paul Vijay K. Yechoor Mariana G. Figueiro Modulating light level patterns reduces rest/activity disruption associated with shiftwork npj Biological Timing and Sleep |
| title | Modulating light level patterns reduces rest/activity disruption associated with shiftwork |
| title_full | Modulating light level patterns reduces rest/activity disruption associated with shiftwork |
| title_fullStr | Modulating light level patterns reduces rest/activity disruption associated with shiftwork |
| title_full_unstemmed | Modulating light level patterns reduces rest/activity disruption associated with shiftwork |
| title_short | Modulating light level patterns reduces rest/activity disruption associated with shiftwork |
| title_sort | modulating light level patterns reduces rest activity disruption associated with shiftwork |
| url | https://doi.org/10.1038/s44323-025-00043-3 |
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