Possibility of alleviating dextran sulfate sodium-induced colitis in mice by modulate intestinal barrier function and gut microbiota with laminarin acetyl esters
This study investigates the esterification of laminarin, a β-glucan polysaccharide, using trifluoroacetic anhydride and acetic acid to synthesize laminarin acetyl esters (LA) with potential therapeutic properties. The efficacy of LA was evaluated in an in vivo dextran sulfate sodium induced colitis...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893925000325 |
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| author | Kit-Leong Cheong Amanullah Sabir Suresh Veeraperumal Franck Quero Rui Li Qiaoli Zhao Karsoon Tan Saiyi Zhong Udayakumar Veerabagu |
| author_facet | Kit-Leong Cheong Amanullah Sabir Suresh Veeraperumal Franck Quero Rui Li Qiaoli Zhao Karsoon Tan Saiyi Zhong Udayakumar Veerabagu |
| author_sort | Kit-Leong Cheong |
| collection | DOAJ |
| description | This study investigates the esterification of laminarin, a β-glucan polysaccharide, using trifluoroacetic anhydride and acetic acid to synthesize laminarin acetyl esters (LA) with potential therapeutic properties. The efficacy of LA was evaluated in an in vivo dextran sulfate sodium induced colitis mouse model. Treatment with LA significantly improved the organ index and modulated inflammatory responses by upregulating anti-inflammatory cytokines, such as IL-10 and TGF-β1. LA also promoted a favorable shift in gut microbiota composition, notably increasing the relative abundance of beneficial bacteria like Lactobacillus and Bifidobacterium, and enhancing short-chain fatty acid production, particularly acetic acid. Immunohistochemical analysis revealed a reduction in CD68 expression and an elevation in CD163 expression, indicating a shift toward an anti-inflammatory macrophage phenotype. These findings demonstrate that LA mitigates pro-inflammatory responses, enhances gut barrier integrity, and supports a healthy gut microbiota, underscoring its potential as a therapeutic agent for managing colitis and improving gut health. |
| format | Article |
| id | doaj-art-8040505756da4c7e82a667c875a361e5 |
| institution | Kabale University |
| issn | 2666-8939 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj-art-8040505756da4c7e82a667c875a361e52025-02-07T04:48:27ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392025-03-019100693Possibility of alleviating dextran sulfate sodium-induced colitis in mice by modulate intestinal barrier function and gut microbiota with laminarin acetyl estersKit-Leong Cheong0Amanullah Sabir1Suresh Veeraperumal2Franck Quero3Rui Li4Qiaoli Zhao5Karsoon Tan6Saiyi Zhong7Udayakumar Veerabagu8College of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Provincial Engineering Technology Research Center of Prefabricated Seafood Processing and Quality Control, Guangdong Ocean University, Zhanjiang 524088, China; Department of Biology, College of Science, Shantou University, Guangdong, ChinaCollege of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Provincial Engineering Technology Research Center of Prefabricated Seafood Processing and Quality Control, Guangdong Ocean University, Zhanjiang 524088, ChinaDepartment of Biology, College of Science, Shantou University, Guangdong, ChinaLaboratorio de Nanocelulosa y Biomateriales, Departamento de Ingeniería Química, Biotecnología y Materiales, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, Santiago 8370456, ChileCollege of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Provincial Engineering Technology Research Center of Prefabricated Seafood Processing and Quality Control, Guangdong Ocean University, Zhanjiang 524088, ChinaCollege of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Provincial Engineering Technology Research Center of Prefabricated Seafood Processing and Quality Control, Guangdong Ocean University, Zhanjiang 524088, ChinaGuangxi Key Laboratory of Beibu Gulf Biodiversity Conservation, Beibu Gulf University, Qinzhou, Guangxi, China; Corresponding authors.College of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Provincial Engineering Technology Research Center of Prefabricated Seafood Processing and Quality Control, Guangdong Ocean University, Zhanjiang 524088, China; Corresponding authors.Laboratorio de Nanocelulosa y Biomateriales, Departamento de Ingeniería Química, Biotecnología y Materiales, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, Santiago 8370456, Chile; Corresponding authors.This study investigates the esterification of laminarin, a β-glucan polysaccharide, using trifluoroacetic anhydride and acetic acid to synthesize laminarin acetyl esters (LA) with potential therapeutic properties. The efficacy of LA was evaluated in an in vivo dextran sulfate sodium induced colitis mouse model. Treatment with LA significantly improved the organ index and modulated inflammatory responses by upregulating anti-inflammatory cytokines, such as IL-10 and TGF-β1. LA also promoted a favorable shift in gut microbiota composition, notably increasing the relative abundance of beneficial bacteria like Lactobacillus and Bifidobacterium, and enhancing short-chain fatty acid production, particularly acetic acid. Immunohistochemical analysis revealed a reduction in CD68 expression and an elevation in CD163 expression, indicating a shift toward an anti-inflammatory macrophage phenotype. These findings demonstrate that LA mitigates pro-inflammatory responses, enhances gut barrier integrity, and supports a healthy gut microbiota, underscoring its potential as a therapeutic agent for managing colitis and improving gut health.http://www.sciencedirect.com/science/article/pii/S2666893925000325LaminarinLaminarin acetyl estersUlcerative colitisGut integrityInflammation |
| spellingShingle | Kit-Leong Cheong Amanullah Sabir Suresh Veeraperumal Franck Quero Rui Li Qiaoli Zhao Karsoon Tan Saiyi Zhong Udayakumar Veerabagu Possibility of alleviating dextran sulfate sodium-induced colitis in mice by modulate intestinal barrier function and gut microbiota with laminarin acetyl esters Carbohydrate Polymer Technologies and Applications Laminarin Laminarin acetyl esters Ulcerative colitis Gut integrity Inflammation |
| title | Possibility of alleviating dextran sulfate sodium-induced colitis in mice by modulate intestinal barrier function and gut microbiota with laminarin acetyl esters |
| title_full | Possibility of alleviating dextran sulfate sodium-induced colitis in mice by modulate intestinal barrier function and gut microbiota with laminarin acetyl esters |
| title_fullStr | Possibility of alleviating dextran sulfate sodium-induced colitis in mice by modulate intestinal barrier function and gut microbiota with laminarin acetyl esters |
| title_full_unstemmed | Possibility of alleviating dextran sulfate sodium-induced colitis in mice by modulate intestinal barrier function and gut microbiota with laminarin acetyl esters |
| title_short | Possibility of alleviating dextran sulfate sodium-induced colitis in mice by modulate intestinal barrier function and gut microbiota with laminarin acetyl esters |
| title_sort | possibility of alleviating dextran sulfate sodium induced colitis in mice by modulate intestinal barrier function and gut microbiota with laminarin acetyl esters |
| topic | Laminarin Laminarin acetyl esters Ulcerative colitis Gut integrity Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2666893925000325 |
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