A polymeric dexamethasone prodrug attenuates focal segmental glomerulosclerosis (FSGS) in an Adriamycin-induced mouse model with minimal glucocorticoid side effects

A polymeric dexamethasone prodrug attenuates focal segmental glomerulosclerosis (FSGS) in an Adriamycin-induced mouse model with minimal glucocorticoid side effects

Focal segmental glomerulosclerosis (FSGS) is chronic renal injury characterized by proteinuria and podocyte injury with glomerulus scarring and tubulointerstitial fibrosis. Glucocorticoids (GCs) are the current first-line treatment. Long-term use of GCs, however, is associated with numerous off-targ...

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Bibliographic Details
Main Authors: Haochen Jiang, Xin Fu, Salma Althobaiti, Braeden Pinkerton, Shabnam Arash, Xiaoqing Du, Zhenshan Jia, Fang Yu, Kirk W. Foster, Geoffrey M. Thiele, Troy J. Plumb, Dong Wang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-03-01
Series:Smart Materials in Medicine
Subjects:
Dexamethasone
Glucocorticoids
Focal segmental glomerulosclerosis (FSGS)
Polymeric prodrug
Toxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2590183425000055
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