Dental Stem Cell-Derived Secretome/Conditioned Medium: The Future for Regenerative Therapeutic Applications
Regenerative medicine literature has proposed mesenchymal stem/progenitor cell- (MSC-) mediated therapeutic approaches for their great potential in managing various diseases and tissue defects. Dental MSCs represent promising alternatives to nondental MSCs, owing to their ease of harvesting with min...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2020/7593402 |
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| _version_ | 1850215384893882368 |
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| author | Sara El Moshy Israa Ahmed Radwan Dina Rady Marwa M. S. Abbass Aiah A. El-Rashidy Khadiga M. Sadek Christof E. Dörfer Karim M. Fawzy El-Sayed |
| author_facet | Sara El Moshy Israa Ahmed Radwan Dina Rady Marwa M. S. Abbass Aiah A. El-Rashidy Khadiga M. Sadek Christof E. Dörfer Karim M. Fawzy El-Sayed |
| author_sort | Sara El Moshy |
| collection | DOAJ |
| description | Regenerative medicine literature has proposed mesenchymal stem/progenitor cell- (MSC-) mediated therapeutic approaches for their great potential in managing various diseases and tissue defects. Dental MSCs represent promising alternatives to nondental MSCs, owing to their ease of harvesting with minimally invasive procedures. Their mechanism of action has been attributed to their cell-to-cell contacts as well as to the paracrine effect of their secreted factors, namely, secretome. In this context, dental MSC-derived secretome/conditioned medium could represent a unique cell-free regenerative and therapeutic approach, with fascinating advantages over parent cells. This article reviews the application of different populations of dental MSC secretome/conditioned medium in in vitro and in vivo animal models, highlights their significant implementation in treating different tissue’ diseases, and clarifies the significant bioactive molecules involved in their regenerative potential. The analysis of these recent studies clearly indicate that dental MSCs’ secretome/conditioned medium could be effective in treating neural injuries, for dental tissue regeneration, in repairing bone defects, and in managing cardiovascular diseases, diabetes mellitus, hepatic regeneration, and skin injuries, through regulating anti-inflammatory, antiapoptotic, angiogenic, osteogenic, and neurogenic mediators. |
| format | Article |
| id | doaj-art-803b052498e548fdb4cec608206cb90e |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-803b052498e548fdb4cec608206cb90e2025-08-20T02:08:38ZengWileyStem Cells International1687-966X1687-96782020-01-01202010.1155/2020/75934027593402Dental Stem Cell-Derived Secretome/Conditioned Medium: The Future for Regenerative Therapeutic ApplicationsSara El Moshy0Israa Ahmed Radwan1Dina Rady2Marwa M. S. Abbass3Aiah A. El-Rashidy4Khadiga M. Sadek5Christof E. Dörfer6Karim M. Fawzy El-Sayed7Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, EgyptOral Biology Department, Faculty of Dentistry, Cairo University, Cairo, EgyptOral Biology Department, Faculty of Dentistry, Cairo University, Cairo, EgyptOral Biology Department, Faculty of Dentistry, Cairo University, Cairo, EgyptStem cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, EgyptStem cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, EgyptClinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, Kiel, GermanyStem cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, EgyptRegenerative medicine literature has proposed mesenchymal stem/progenitor cell- (MSC-) mediated therapeutic approaches for their great potential in managing various diseases and tissue defects. Dental MSCs represent promising alternatives to nondental MSCs, owing to their ease of harvesting with minimally invasive procedures. Their mechanism of action has been attributed to their cell-to-cell contacts as well as to the paracrine effect of their secreted factors, namely, secretome. In this context, dental MSC-derived secretome/conditioned medium could represent a unique cell-free regenerative and therapeutic approach, with fascinating advantages over parent cells. This article reviews the application of different populations of dental MSC secretome/conditioned medium in in vitro and in vivo animal models, highlights their significant implementation in treating different tissue’ diseases, and clarifies the significant bioactive molecules involved in their regenerative potential. The analysis of these recent studies clearly indicate that dental MSCs’ secretome/conditioned medium could be effective in treating neural injuries, for dental tissue regeneration, in repairing bone defects, and in managing cardiovascular diseases, diabetes mellitus, hepatic regeneration, and skin injuries, through regulating anti-inflammatory, antiapoptotic, angiogenic, osteogenic, and neurogenic mediators.http://dx.doi.org/10.1155/2020/7593402 |
| spellingShingle | Sara El Moshy Israa Ahmed Radwan Dina Rady Marwa M. S. Abbass Aiah A. El-Rashidy Khadiga M. Sadek Christof E. Dörfer Karim M. Fawzy El-Sayed Dental Stem Cell-Derived Secretome/Conditioned Medium: The Future for Regenerative Therapeutic Applications Stem Cells International |
| title | Dental Stem Cell-Derived Secretome/Conditioned Medium: The Future for Regenerative Therapeutic Applications |
| title_full | Dental Stem Cell-Derived Secretome/Conditioned Medium: The Future for Regenerative Therapeutic Applications |
| title_fullStr | Dental Stem Cell-Derived Secretome/Conditioned Medium: The Future for Regenerative Therapeutic Applications |
| title_full_unstemmed | Dental Stem Cell-Derived Secretome/Conditioned Medium: The Future for Regenerative Therapeutic Applications |
| title_short | Dental Stem Cell-Derived Secretome/Conditioned Medium: The Future for Regenerative Therapeutic Applications |
| title_sort | dental stem cell derived secretome conditioned medium the future for regenerative therapeutic applications |
| url | http://dx.doi.org/10.1155/2020/7593402 |
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