Intraarticular gold for knee osteoarthritis: An ancillary analysis of biomarkers and outcome of a pilot study
Objective: In a previous pilot study, we have shown that intraarticular gold micro-particles can reduce knee osteoarthritis (KOA) pain at two years follow-up. Proteomic changes in serum and synovial fluid within eight weeks were associated with multiple inflammatory and immunological processes. The...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Osteoarthritis and Cartilage Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665913124000815 |
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| author | Sten Rasmussen Christopher Aboo Jacob Skallerup Allan Stensballe |
| author_facet | Sten Rasmussen Christopher Aboo Jacob Skallerup Allan Stensballe |
| author_sort | Sten Rasmussen |
| collection | DOAJ |
| description | Objective: In a previous pilot study, we have shown that intraarticular gold micro-particles can reduce knee osteoarthritis (KOA) pain at two years follow-up. Proteomic changes in serum and synovial fluid within eight weeks were associated with multiple inflammatory and immunological processes. The relation between the different biomarkers and the outcome measures is not known. We hypothesized that improvement in pain and function were associated with specific groups of biomarkers. We present the integrative analyses between proteomic biomarkers and outcomes. Design: A cohort of 30 patients, with moderate KOA, were included. Using the patients’ synovial fluid as the carrier, 20 mg gold microparticles were injected intraarticularly. Clinical outcome measures at inclusion, 8 weeks, and 2 years, were the PainDetect questionnaire, WOMAC pain, stiffness, and function. In addition, Quantitative Sensory Testing, Pain Pressure Threshold, Temporal Summation, Conditioned Pain Modulation, and pain diary were assessed at inclusion and after 8 weeks. Proteomic analysis was performed on SF and blood samples before and after 8 weeks of treatment. Results: Linear combinations of serum or synovial biomarkers changed significantly alongside the effect measures and PainDetect scores following gold micro-particle treatment. Of particular interest was identifying multiple members of a molecular complex that is suggestive of neural tissue regeneration and modulation following gold micro-particle treatment. Conclusions: Gold microparticles are a possible future option for the treatment of knee osteoarthritis. The treatment triggers putative regenerative and inflammation-modulating molecular mechanisms. |
| format | Article |
| id | doaj-art-8038d60e2086473badff068e7cb89655 |
| institution | OA Journals |
| issn | 2665-9131 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Osteoarthritis and Cartilage Open |
| spelling | doaj-art-8038d60e2086473badff068e7cb896552025-08-20T02:05:28ZengElsevierOsteoarthritis and Cartilage Open2665-91312024-12-016410051410.1016/j.ocarto.2024.100514Intraarticular gold for knee osteoarthritis: An ancillary analysis of biomarkers and outcome of a pilot studySten Rasmussen0Christopher Aboo1Jacob Skallerup2Allan Stensballe3Department of Orthopedic Surgery, Sport and Arthroscopy, Aalborg University Hospital, Denmark; Department of Clinical Medicine, Aalborg University, Denmark; Corresponding author. Department of Clinical Medicine, Aalborg University, Selma Lagerlofsvej 249, 9260, Gistrup, Denmark.Department of Health Science and Technology, Aalborg University, Aalborg, Denmark; Sino-Danish Center for Education and Research, University of Chinese Academy of Sciences, Beijing, ChinaDepartment of Health Science and Technology, Aalborg University, Aalborg, Denmark; Sino-Danish Center for Education and Research, University of Chinese Academy of Sciences, Beijing, ChinaDepartment of Health Science and Technology, Aalborg University, Aalborg, Denmark; Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark; Sino-Danish Center for Education and Research, University of Chinese Academy of Sciences, Beijing, ChinaObjective: In a previous pilot study, we have shown that intraarticular gold micro-particles can reduce knee osteoarthritis (KOA) pain at two years follow-up. Proteomic changes in serum and synovial fluid within eight weeks were associated with multiple inflammatory and immunological processes. The relation between the different biomarkers and the outcome measures is not known. We hypothesized that improvement in pain and function were associated with specific groups of biomarkers. We present the integrative analyses between proteomic biomarkers and outcomes. Design: A cohort of 30 patients, with moderate KOA, were included. Using the patients’ synovial fluid as the carrier, 20 mg gold microparticles were injected intraarticularly. Clinical outcome measures at inclusion, 8 weeks, and 2 years, were the PainDetect questionnaire, WOMAC pain, stiffness, and function. In addition, Quantitative Sensory Testing, Pain Pressure Threshold, Temporal Summation, Conditioned Pain Modulation, and pain diary were assessed at inclusion and after 8 weeks. Proteomic analysis was performed on SF and blood samples before and after 8 weeks of treatment. Results: Linear combinations of serum or synovial biomarkers changed significantly alongside the effect measures and PainDetect scores following gold micro-particle treatment. Of particular interest was identifying multiple members of a molecular complex that is suggestive of neural tissue regeneration and modulation following gold micro-particle treatment. Conclusions: Gold microparticles are a possible future option for the treatment of knee osteoarthritis. The treatment triggers putative regenerative and inflammation-modulating molecular mechanisms.http://www.sciencedirect.com/science/article/pii/S2665913124000815OsteoarthritisOmicsGoldInflammationPainOutcome prediction |
| spellingShingle | Sten Rasmussen Christopher Aboo Jacob Skallerup Allan Stensballe Intraarticular gold for knee osteoarthritis: An ancillary analysis of biomarkers and outcome of a pilot study Osteoarthritis and Cartilage Open Osteoarthritis Omics Gold Inflammation Pain Outcome prediction |
| title | Intraarticular gold for knee osteoarthritis: An ancillary analysis of biomarkers and outcome of a pilot study |
| title_full | Intraarticular gold for knee osteoarthritis: An ancillary analysis of biomarkers and outcome of a pilot study |
| title_fullStr | Intraarticular gold for knee osteoarthritis: An ancillary analysis of biomarkers and outcome of a pilot study |
| title_full_unstemmed | Intraarticular gold for knee osteoarthritis: An ancillary analysis of biomarkers and outcome of a pilot study |
| title_short | Intraarticular gold for knee osteoarthritis: An ancillary analysis of biomarkers and outcome of a pilot study |
| title_sort | intraarticular gold for knee osteoarthritis an ancillary analysis of biomarkers and outcome of a pilot study |
| topic | Osteoarthritis Omics Gold Inflammation Pain Outcome prediction |
| url | http://www.sciencedirect.com/science/article/pii/S2665913124000815 |
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