Blockade of PVN neuromedin B receptor alleviates inflammation via the RAS/ROS/NF-κB pathway in spontaneously hypertensive rats

Blockade of PVN neuromedin B receptor alleviates inflammation via the RAS/ROS/NF-κB pathway in spontaneously hypertensive rats

Neuromedin B (NMB) has potentially great impacts on the development of cardiovascular diseases by promoting hypertensive and sympatho-excitation effects. However, studies regarding the NMB function in paraventricular nucleus (PVN) are lacking. With selective neuromedin B receptor (NMBR) antagonist,...

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Bibliographic Details
Main Authors: Kai-Li Liu, Tian-Ze Sun, Yu Yang, Qian-Xi Gao, Li-Mei Tu, Jia-Yue Yu, Qiao-Zhen Tian, Li-Yan Fu, Shu-Huan Tang, Hong-Li Gao, Jie Qi, Yu-Ming Kang, Xiao-Jing Yu
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Brain Research Bulletin
Subjects:
Neuromedin B receptor
PVN
Inflammation
RAS/ROS/ NF-κB pathway
Hypertension
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923024003149
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