Trabeculectomy with mitomycin C for glaucoma secondary to emulsified silicone oil after pars plana vitrectomy: three-years follow up
Background/Aim. Different surgical interventions have been proposed, including trabeculectomy associated with antiproliferative agents because silicone oil (SO) removal cannot necessarily provide intraocular pressure (IOP) control. The aim of the study was to determine the efficacy of trabeculectomy...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2022-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502200001M.pdf |
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| author | Marjanović Ivan Gvozdenović Ranko Božić Marija Marić Vesna Stojković Milenko Marjanović Marija Jordanova Elena Martinez Antonio |
| author_facet | Marjanović Ivan Gvozdenović Ranko Božić Marija Marić Vesna Stojković Milenko Marjanović Marija Jordanova Elena Martinez Antonio |
| author_sort | Marjanović Ivan |
| collection | DOAJ |
| description | Background/Aim. Different surgical interventions have been proposed, including trabeculectomy associated with antiproliferative agents because silicone oil (SO) removal cannot necessarily provide intraocular pressure (IOP) control. The aim of the study was to determine the efficacy of trabeculectomy with mitomycin C (MMC) for lowering IOP in patients with open-angle glaucoma (OAG) secondary to emulsified SO after pars plana vitrectomy. Methods. A single-center, prospective study was conducted, from December 2014 to December 2019, on 56 consecutive patients with an uncontrolled elevation of IOP after SO removal who were subjected to trabeculectomy with mitomycin MMC in that period. The primary end-point was the IOP at the three-year follow-up visit. Complete surgical success was defined as an IOP ranging from 7 mmHg to 18 mmHg without glaucoma medication. Qualified success was defined a s I OP ≤ 2 1 m mHg with one or two topical medications. Results. Fifty-six patients with a mean age of 5 3.6 [standard deviation (SD)15.5] years had a mean baseline IOP of 42.3 (39.3 to 45.3) mmHg, which reduced to 18.6 (17.9 to 19.3) mmHg three years after surgery (p < 0.0001). Seventeen (30.4%) eyes were classified as a complete success, 21 (37,5%) as a qualified success, and 18 (32.1%) as a failure. In all successfully treated patients, the number of antiglaucoma medications was significantly reduced from 2.85 (SD 0.77) to 1.63 (SD 0.62), p < 0.0001. Conclusion. Trabeculectomy with MMC may be an option for lowering IOP in patients with OAG secondary to emulsified SO after pars plana vitrectomy, which was not controlled with maximum |
| format | Article |
| id | doaj-art-80359040b0a34dff8e78a0ec6eca20dc |
| institution | Kabale University |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-80359040b0a34dff8e78a0ec6eca20dc2025-08-20T03:35:15ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202022-01-0179121233123810.2298/VSP200428001M0042-84502200001MTrabeculectomy with mitomycin C for glaucoma secondary to emulsified silicone oil after pars plana vitrectomy: three-years follow upMarjanović Ivan0Gvozdenović Ranko1Božić Marija2https://orcid.org/0000-0002-0367-5906Marić Vesna3https://orcid.org/0000-0003-3109-0531Stojković Milenko4Marjanović Marija5Jordanova Elena6https://orcid.org/0000-0003-2698-6843Martinez Antonio7University Clinical Center of Serbia, Eye Clinic, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity Clinical Center of Serbia, Eye Clinic, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity Clinical Center of Serbia, Eye Clinic, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity Clinical Center of Serbia, Eye Clinic, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity Clinical Center of Serbia, Eye Clinic, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Belgrade, Serbia + University Clinical Center of Serbia, Cardiology Clinic, Belgrade, SerbiaClinical Hospital Center Zemun, Clinic for Internal Medicine, Department of Nephrology, Belgrade, SerbiaClinical Research Department, Science Research and Sports, Ames, La Coruna, SpainBackground/Aim. Different surgical interventions have been proposed, including trabeculectomy associated with antiproliferative agents because silicone oil (SO) removal cannot necessarily provide intraocular pressure (IOP) control. The aim of the study was to determine the efficacy of trabeculectomy with mitomycin C (MMC) for lowering IOP in patients with open-angle glaucoma (OAG) secondary to emulsified SO after pars plana vitrectomy. Methods. A single-center, prospective study was conducted, from December 2014 to December 2019, on 56 consecutive patients with an uncontrolled elevation of IOP after SO removal who were subjected to trabeculectomy with mitomycin MMC in that period. The primary end-point was the IOP at the three-year follow-up visit. Complete surgical success was defined as an IOP ranging from 7 mmHg to 18 mmHg without glaucoma medication. Qualified success was defined a s I OP ≤ 2 1 m mHg with one or two topical medications. Results. Fifty-six patients with a mean age of 5 3.6 [standard deviation (SD)15.5] years had a mean baseline IOP of 42.3 (39.3 to 45.3) mmHg, which reduced to 18.6 (17.9 to 19.3) mmHg three years after surgery (p < 0.0001). Seventeen (30.4%) eyes were classified as a complete success, 21 (37,5%) as a qualified success, and 18 (32.1%) as a failure. In all successfully treated patients, the number of antiglaucoma medications was significantly reduced from 2.85 (SD 0.77) to 1.63 (SD 0.62), p < 0.0001. Conclusion. Trabeculectomy with MMC may be an option for lowering IOP in patients with OAG secondary to emulsified SO after pars plana vitrectomy, which was not controlled with maximumhttp://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502200001M.pdfglaucoma, open-anglemitomycinophthalmologic surgical proceduressilicone oilstrabeculectomy |
| spellingShingle | Marjanović Ivan Gvozdenović Ranko Božić Marija Marić Vesna Stojković Milenko Marjanović Marija Jordanova Elena Martinez Antonio Trabeculectomy with mitomycin C for glaucoma secondary to emulsified silicone oil after pars plana vitrectomy: three-years follow up Vojnosanitetski Pregled glaucoma, open-angle mitomycin ophthalmologic surgical procedures silicone oils trabeculectomy |
| title | Trabeculectomy with mitomycin C for glaucoma secondary to emulsified silicone oil after pars plana vitrectomy: three-years follow up |
| title_full | Trabeculectomy with mitomycin C for glaucoma secondary to emulsified silicone oil after pars plana vitrectomy: three-years follow up |
| title_fullStr | Trabeculectomy with mitomycin C for glaucoma secondary to emulsified silicone oil after pars plana vitrectomy: three-years follow up |
| title_full_unstemmed | Trabeculectomy with mitomycin C for glaucoma secondary to emulsified silicone oil after pars plana vitrectomy: three-years follow up |
| title_short | Trabeculectomy with mitomycin C for glaucoma secondary to emulsified silicone oil after pars plana vitrectomy: three-years follow up |
| title_sort | trabeculectomy with mitomycin c for glaucoma secondary to emulsified silicone oil after pars plana vitrectomy three years follow up |
| topic | glaucoma, open-angle mitomycin ophthalmologic surgical procedures silicone oils trabeculectomy |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502200001M.pdf |
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