CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth.
New HIV vaccine approaches are focused on eliciting broadly neutralizing antibodies. We characterized early gamma-delta (γδ) T cell responses starting from pre-acquisition and during acute HIV infection (AHI) in participants previously characterized for neutralization breadth development. We found s...
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1012916 |
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| author | Gina L Griffith Kawthar Machmach Ningbo Jian Dohoon Kim Margaret C Costanzo Matthew Creegan Isabella Swafford Gautam Kundu Lauren Yum Jessica S Bolton Lauren Smith Bonnie M Slike Elke S Bergmann-Leitner Rasmi Thomas Nelson L Michael Julie A Ake Leigh Anne Eller Merlin L Robb Samantha M Townsley Shelly J Krebs Dominic Paquin-Proulx RV217 Study Group |
| author_facet | Gina L Griffith Kawthar Machmach Ningbo Jian Dohoon Kim Margaret C Costanzo Matthew Creegan Isabella Swafford Gautam Kundu Lauren Yum Jessica S Bolton Lauren Smith Bonnie M Slike Elke S Bergmann-Leitner Rasmi Thomas Nelson L Michael Julie A Ake Leigh Anne Eller Merlin L Robb Samantha M Townsley Shelly J Krebs Dominic Paquin-Proulx RV217 Study Group |
| author_sort | Gina L Griffith |
| collection | DOAJ |
| description | New HIV vaccine approaches are focused on eliciting broadly neutralizing antibodies. We characterized early gamma-delta (γδ) T cell responses starting from pre-acquisition and during acute HIV infection (AHI) in participants previously characterized for neutralization breadth development. We found significant differences in γδ T cell surface marker expression in participants that developed neutralization breadth compared to those that did not. Activation of γδ T cells occurred within the first weeks of HIV acquisition and associated with viral load. Expression of CD16 on Vδ1 T cells and CD57 on Vδ2 T cells were found to be significantly higher in broad neutralizers during AHI, and associated with the development of neutralization breadth years later. In addition, the levels of CD16 on Vδ1 T cells was associated with early production of founder virus Env-specific IgM. Thus, γδ T cells may promote development of neutralization breadth, which has implications for HIV vaccine strategies. |
| format | Article |
| id | doaj-art-803139ceb7354ab29331aa98f1ef5a47 |
| institution | Kabale University |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-803139ceb7354ab29331aa98f1ef5a472025-02-12T05:30:43ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742025-01-01211e101291610.1371/journal.ppat.1012916CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth.Gina L GriffithKawthar MachmachNingbo JianDohoon KimMargaret C CostanzoMatthew CreeganIsabella SwaffordGautam KunduLauren YumJessica S BoltonLauren SmithBonnie M SlikeElke S Bergmann-LeitnerRasmi ThomasNelson L MichaelJulie A AkeLeigh Anne EllerMerlin L RobbSamantha M TownsleyShelly J KrebsDominic Paquin-ProulxRV217 Study GroupNew HIV vaccine approaches are focused on eliciting broadly neutralizing antibodies. We characterized early gamma-delta (γδ) T cell responses starting from pre-acquisition and during acute HIV infection (AHI) in participants previously characterized for neutralization breadth development. We found significant differences in γδ T cell surface marker expression in participants that developed neutralization breadth compared to those that did not. Activation of γδ T cells occurred within the first weeks of HIV acquisition and associated with viral load. Expression of CD16 on Vδ1 T cells and CD57 on Vδ2 T cells were found to be significantly higher in broad neutralizers during AHI, and associated with the development of neutralization breadth years later. In addition, the levels of CD16 on Vδ1 T cells was associated with early production of founder virus Env-specific IgM. Thus, γδ T cells may promote development of neutralization breadth, which has implications for HIV vaccine strategies.https://doi.org/10.1371/journal.ppat.1012916 |
| spellingShingle | Gina L Griffith Kawthar Machmach Ningbo Jian Dohoon Kim Margaret C Costanzo Matthew Creegan Isabella Swafford Gautam Kundu Lauren Yum Jessica S Bolton Lauren Smith Bonnie M Slike Elke S Bergmann-Leitner Rasmi Thomas Nelson L Michael Julie A Ake Leigh Anne Eller Merlin L Robb Samantha M Townsley Shelly J Krebs Dominic Paquin-Proulx RV217 Study Group CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth. PLoS Pathogens |
| title | CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth. |
| title_full | CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth. |
| title_fullStr | CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth. |
| title_full_unstemmed | CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth. |
| title_short | CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth. |
| title_sort | cd16 and cd57 expressing gamma delta t cells in acute hiv 1 infection are associated with the development of neutralization breadth |
| url | https://doi.org/10.1371/journal.ppat.1012916 |
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