Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma
Abnormal expression of long non-coding RNA often contributes to unrestricted growth of cancer cells. Long non-coding RNA XIST expression is upregulated in several cancers; however, its modulatory mechanisms have not been reported in hepatocellular carcinoma. In this study, we found that XIST express...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-02-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317690999 |
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| _version_ | 1849251141675646976 |
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| author | Yichao Mo Yaoyong Lu Peng Wang Simin Huang Longguang He Dasheng Li Fuliang Li Junwei Huang Xiaoxia Lin Xueru Li Siyao Che Qinshou Chen |
| author_facet | Yichao Mo Yaoyong Lu Peng Wang Simin Huang Longguang He Dasheng Li Fuliang Li Junwei Huang Xiaoxia Lin Xueru Li Siyao Che Qinshou Chen |
| author_sort | Yichao Mo |
| collection | DOAJ |
| description | Abnormal expression of long non-coding RNA often contributes to unrestricted growth of cancer cells. Long non-coding RNA XIST expression is upregulated in several cancers; however, its modulatory mechanisms have not been reported in hepatocellular carcinoma. In this study, we found that XIST expression was significantly increased in hepatocellular carcinoma tissues and cell lines. XIST promoted cell cycle progression from the G1 phase to the S phase and protected cells from apoptosis, which contributed to hepatocellular carcinoma cell growth. In addition, we revealed that there was reciprocal repression between XIST and miR-139-5p. PDK1 was identified as a direct target of miR-139-5p. We proposed that XIST was responsible for hepatocellular carcinoma cell proliferation, and XIST exerted its function through the miR-139-5p/PDK1 axis. |
| format | Article |
| id | doaj-art-802da1df7d74453eb1fee95110b77a27 |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-802da1df7d74453eb1fee95110b77a272025-08-20T03:57:03ZengSAGE PublishingTumor Biology1423-03802017-02-013910.1177/1010428317690999Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinomaYichao Mo0Yaoyong Lu1Peng Wang2Simin Huang3Longguang He4Dasheng Li5Fuliang Li6Junwei Huang7Xiaoxia Lin8Xueru Li9Siyao Che10Qinshou Chen11Department of Hepatobiliary Surgery, Gaozhou People’s Hospital, Gaozhou, ChinaDepartment of Radiation Oncology, Gaozhou People’s Hospital, Gaozhou, ChinaMacau University of Science and Technology, Taipa, MacauGraduate School of Guangdong Medical College, Zhanjiang, ChinaDepartment of Hepatobiliary Surgery, Gaozhou People’s Hospital, Gaozhou, ChinaDepartment of Hepatobiliary Surgery, Gaozhou People’s Hospital, Gaozhou, ChinaDepartment of Hepatobiliary Surgery, Gaozhou People’s Hospital, Gaozhou, ChinaDepartment of Hepatobiliary Surgery, Gaozhou People’s Hospital, Gaozhou, ChinaDepartment of Hepatobiliary Surgery, Gaozhou People’s Hospital, Gaozhou, ChinaDepartment of Obstetrics and Gynecology, Shenzhen Nanshan Hospital, Shenzhen, ChinaDepartment of Hepatobiliary Surgery, Gaozhou People’s Hospital, Gaozhou, ChinaDepartment of Hepatobiliary Surgery, Gaozhou People’s Hospital, Gaozhou, ChinaAbnormal expression of long non-coding RNA often contributes to unrestricted growth of cancer cells. Long non-coding RNA XIST expression is upregulated in several cancers; however, its modulatory mechanisms have not been reported in hepatocellular carcinoma. In this study, we found that XIST expression was significantly increased in hepatocellular carcinoma tissues and cell lines. XIST promoted cell cycle progression from the G1 phase to the S phase and protected cells from apoptosis, which contributed to hepatocellular carcinoma cell growth. In addition, we revealed that there was reciprocal repression between XIST and miR-139-5p. PDK1 was identified as a direct target of miR-139-5p. We proposed that XIST was responsible for hepatocellular carcinoma cell proliferation, and XIST exerted its function through the miR-139-5p/PDK1 axis.https://doi.org/10.1177/1010428317690999 |
| spellingShingle | Yichao Mo Yaoyong Lu Peng Wang Simin Huang Longguang He Dasheng Li Fuliang Li Junwei Huang Xiaoxia Lin Xueru Li Siyao Che Qinshou Chen Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma Tumor Biology |
| title | Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma |
| title_full | Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma |
| title_fullStr | Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma |
| title_full_unstemmed | Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma |
| title_short | Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma |
| title_sort | long non coding rna xist promotes cell growth by regulating mir 139 5p pdk1 akt axis in hepatocellular carcinoma |
| url | https://doi.org/10.1177/1010428317690999 |
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