A dual binding mode for RhoGTPases in plexin signalling.

A dual binding mode for RhoGTPases in plexin signalling.

Plexins are cell surface receptors for the semaphorin family of cell guidance cues. The cytoplasmic region comprises a Ras GTPase-activating protein (GAP) domain and a RhoGTPase binding domain. Concomitant binding of extracellular semaphorin and intracellular RhoGTPase triggers GAP activity and sign...

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Bibliographic Details
Main Authors: Christian H Bell, A Radu Aricescu, E Yvonne Jones, Christian Siebold
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-08-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001134&type=printable
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