Post-COVID Syndrome: Persistence of Symptoms and Risk Factors (Longitudinal Observational Study)
The aim - studying the dynamics of symptoms of post-COVID syndrome (depending on the results of depending on the results of the polymerase chain reaction for SARS-CoV-2) and the factors influencing it.Materials and methods. A study is a cohort, observational longitudinal. Stage I: snapshot analysis...
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SINAPS LLC
2024-04-01
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| Series: | Архивъ внутренней медицины |
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| Online Access: | https://www.medarhive.ru/jour/article/view/1749 |
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| author | T. Yu. Agafonova N. N. Elovikova O. V. Bronnikova D. A. Golyadinets |
| author_facet | T. Yu. Agafonova N. N. Elovikova O. V. Bronnikova D. A. Golyadinets |
| author_sort | T. Yu. Agafonova |
| collection | DOAJ |
| description | The aim - studying the dynamics of symptoms of post-COVID syndrome (depending on the results of depending on the results of the polymerase chain reaction for SARS-CoV-2) and the factors influencing it.Materials and methods. A study is a cohort, observational longitudinal. Stage I: snapshot analysis of medical records of patients with COVID-19 disease history 12 months. (questionnaire for post-COVID syndrome, blood tests). Stage II: questionnaire repeat, disease history — 24 months. There were test (positive polymerase chain reaction, 138 people) and control (negative polymerase chain reaction, 87 people) groups. Statistical analysis: package Statistica 13.5.0.17.Results. 1 year after COVID-19, the frequency of manifestations of post-COVID syndrome was (test vs control group): asthenia 63 % vs 64 %, decreased quality of life 59 % vs 56 %, respiratory syndrome 60 % vs 49 %, arthralgia 55 % vs 49 %, cardiac syndrome 47 % vs 46 % (the difference is not significant); symptoms are associated with female gender (r=0.231- 0.379), severity of COVID-19 (r=0.187-0.425), D-dimer (r=0.244-0.328). After 2 years, the frequency of symptoms was: asthenia 43 % vs 45 %, cardiac symptoms 23 % vs 15 %, respiratory symptoms 18 % vs 22 %, skin manifestations 8 % vs 12 %, decreased quality of life 7 % vs 9 %, the difference is not significant; symptoms are associated with age (r=0.208-0.402). During two years, symptoms have been correlating with platelets (r=-0.322-0.403), liver enzymes (r=0.216-0.298), blood lipids (r=0.188-0.257).Conclusions. The severity of post-COVID syndrome does not depend on the results of the polymerase chain reaction for SARS-CoV-2. The frequency of cardiac and respiratory syndromes after 2 years decreases by 2-3 times; quality of life improves. Asthenia is the most long-term syndrome. Risk factors for post-COVID syndrome during the 1st year — severity of COVID-19, female gender, D-dimer level; from the 2nd year — age. For two years after COVID-19, monitoring of liver enzymes, lipids, and platelets is required. |
| format | Article |
| id | doaj-art-8022a5d0f3634310b6dfe33b2a039c4f |
| institution | DOAJ |
| issn | 2226-6704 2411-6564 |
| language | Russian |
| publishDate | 2024-04-01 |
| publisher | SINAPS LLC |
| record_format | Article |
| series | Архивъ внутренней медицины |
| spelling | doaj-art-8022a5d0f3634310b6dfe33b2a039c4f2025-08-20T02:56:08ZrusSINAPS LLCАрхивъ внутренней медицины2226-67042411-65642024-04-0114210811510.20514/2226-6704-2024-14-2-108-115985Post-COVID Syndrome: Persistence of Symptoms and Risk Factors (Longitudinal Observational Study)T. Yu. Agafonova0N. N. Elovikova1O. V. Bronnikova2D. A. Golyadinets3E.A. Wagner Perm State Medical University of the Ministry of Health. Department of Propaedeutics of Internal Diseases No. 1City PolyclinicE.A. Wagner Perm State Medical University of the Ministry of Health. Department of Propaedeutics of Internal Diseases No. 1E.A. Wagner Perm State Medical University of the Ministry of Health. Department of Propaedeutics of Internal Diseases No. 1The aim - studying the dynamics of symptoms of post-COVID syndrome (depending on the results of depending on the results of the polymerase chain reaction for SARS-CoV-2) and the factors influencing it.Materials and methods. A study is a cohort, observational longitudinal. Stage I: snapshot analysis of medical records of patients with COVID-19 disease history 12 months. (questionnaire for post-COVID syndrome, blood tests). Stage II: questionnaire repeat, disease history — 24 months. There were test (positive polymerase chain reaction, 138 people) and control (negative polymerase chain reaction, 87 people) groups. Statistical analysis: package Statistica 13.5.0.17.Results. 1 year after COVID-19, the frequency of manifestations of post-COVID syndrome was (test vs control group): asthenia 63 % vs 64 %, decreased quality of life 59 % vs 56 %, respiratory syndrome 60 % vs 49 %, arthralgia 55 % vs 49 %, cardiac syndrome 47 % vs 46 % (the difference is not significant); symptoms are associated with female gender (r=0.231- 0.379), severity of COVID-19 (r=0.187-0.425), D-dimer (r=0.244-0.328). After 2 years, the frequency of symptoms was: asthenia 43 % vs 45 %, cardiac symptoms 23 % vs 15 %, respiratory symptoms 18 % vs 22 %, skin manifestations 8 % vs 12 %, decreased quality of life 7 % vs 9 %, the difference is not significant; symptoms are associated with age (r=0.208-0.402). During two years, symptoms have been correlating with platelets (r=-0.322-0.403), liver enzymes (r=0.216-0.298), blood lipids (r=0.188-0.257).Conclusions. The severity of post-COVID syndrome does not depend on the results of the polymerase chain reaction for SARS-CoV-2. The frequency of cardiac and respiratory syndromes after 2 years decreases by 2-3 times; quality of life improves. Asthenia is the most long-term syndrome. Risk factors for post-COVID syndrome during the 1st year — severity of COVID-19, female gender, D-dimer level; from the 2nd year — age. For two years after COVID-19, monitoring of liver enzymes, lipids, and platelets is required.https://www.medarhive.ru/jour/article/view/1749post-covid syndromedynamicspolymerase chain reactionrisk factors |
| spellingShingle | T. Yu. Agafonova N. N. Elovikova O. V. Bronnikova D. A. Golyadinets Post-COVID Syndrome: Persistence of Symptoms and Risk Factors (Longitudinal Observational Study) Архивъ внутренней медицины post-covid syndrome dynamics polymerase chain reaction risk factors |
| title | Post-COVID Syndrome: Persistence of Symptoms and Risk Factors (Longitudinal Observational Study) |
| title_full | Post-COVID Syndrome: Persistence of Symptoms and Risk Factors (Longitudinal Observational Study) |
| title_fullStr | Post-COVID Syndrome: Persistence of Symptoms and Risk Factors (Longitudinal Observational Study) |
| title_full_unstemmed | Post-COVID Syndrome: Persistence of Symptoms and Risk Factors (Longitudinal Observational Study) |
| title_short | Post-COVID Syndrome: Persistence of Symptoms and Risk Factors (Longitudinal Observational Study) |
| title_sort | post covid syndrome persistence of symptoms and risk factors longitudinal observational study |
| topic | post-covid syndrome dynamics polymerase chain reaction risk factors |
| url | https://www.medarhive.ru/jour/article/view/1749 |
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