Cardiac Dysfunction Associated with Lacosamide in a Premature Infant with Hypoxic Ischemic Encephalopathy: A Case Report
Lacosamide (Vimpat Harris FRC Corporation, 2022 UCB, Inc. Smyrna, GA 30080) is an antiseizure medication, which acts through blockage of voltage-gated neuronal sodium channels. Its recent implementation in the neonatal population has been extrapolated from adult and pediatric data suggesting a favor...
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| Format: | Article |
| Language: | English |
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Thieme Medical Publishers, Inc.
2024-07-01
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| Series: | American Journal of Perinatology Reports |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/a-2447-8662 |
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| author | Trassanee Chatmethakul Amy H. Stanford Danielle R. Rios Adrianne R. Bischoff Theresa Czech Patrick J. McNamara |
| author_facet | Trassanee Chatmethakul Amy H. Stanford Danielle R. Rios Adrianne R. Bischoff Theresa Czech Patrick J. McNamara |
| author_sort | Trassanee Chatmethakul |
| collection | DOAJ |
| description | Lacosamide (Vimpat Harris FRC Corporation, 2022 UCB, Inc. Smyrna, GA 30080) is an antiseizure medication, which acts through blockage of voltage-gated neuronal sodium channels. Its recent implementation in the neonatal population has been extrapolated from adult and pediatric data suggesting a favorable safety profile. Of note, preterm infants have unique developmental characteristics that may predispose them to increased risk of adverse reactions. We present a case of a preterm neonate who developed left ventricular dysfunction coinciding with the initiation of lacosamide. |
| format | Article |
| id | doaj-art-801c7c9c6bc44cd59d49e14f9f3437a3 |
| institution | DOAJ |
| issn | 2157-6998 2157-7005 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | American Journal of Perinatology Reports |
| spelling | doaj-art-801c7c9c6bc44cd59d49e14f9f3437a32025-08-20T02:48:10ZengThieme Medical Publishers, Inc.American Journal of Perinatology Reports2157-69982157-70052024-07-011404e270e27310.1055/a-2447-8662Cardiac Dysfunction Associated with Lacosamide in a Premature Infant with Hypoxic Ischemic Encephalopathy: A Case ReportTrassanee Chatmethakul0https://orcid.org/0000-0002-5988-9030Amy H. Stanford1Danielle R. Rios2Adrianne R. Bischoff3Theresa Czech4Patrick J. McNamara5https://orcid.org/0000-0001-7648-8872Department of Pediatrics, Neonatal-Perinatal Medicine Section, University of Oklahoma Health Sciences Center, Oklahoma City, OklahomaDivision of Neonatology, Department of Pediatrics, University of Iowa, Iowa City, IowaDivision of Neonatology, Department of Pediatrics, University of Iowa, Iowa City, IowaDivision of Neonatology, Department of Pediatrics, University of Iowa, Iowa City, IowaPediatric Neurology Division, Department of Pediatrics, University of Iowa, Iowa City, IowaDivision of Neonatology, Department of Pediatrics, University of Iowa, Iowa City, IowaLacosamide (Vimpat Harris FRC Corporation, 2022 UCB, Inc. Smyrna, GA 30080) is an antiseizure medication, which acts through blockage of voltage-gated neuronal sodium channels. Its recent implementation in the neonatal population has been extrapolated from adult and pediatric data suggesting a favorable safety profile. Of note, preterm infants have unique developmental characteristics that may predispose them to increased risk of adverse reactions. We present a case of a preterm neonate who developed left ventricular dysfunction coinciding with the initiation of lacosamide.http://www.thieme-connect.de/DOI/DOI?10.1055/a-2447-8662cardiac dysfunctionantiseizure medicationpreterm infantlacosamide |
| spellingShingle | Trassanee Chatmethakul Amy H. Stanford Danielle R. Rios Adrianne R. Bischoff Theresa Czech Patrick J. McNamara Cardiac Dysfunction Associated with Lacosamide in a Premature Infant with Hypoxic Ischemic Encephalopathy: A Case Report American Journal of Perinatology Reports cardiac dysfunction antiseizure medication preterm infant lacosamide |
| title | Cardiac Dysfunction Associated with Lacosamide in a Premature Infant with Hypoxic Ischemic Encephalopathy: A Case Report |
| title_full | Cardiac Dysfunction Associated with Lacosamide in a Premature Infant with Hypoxic Ischemic Encephalopathy: A Case Report |
| title_fullStr | Cardiac Dysfunction Associated with Lacosamide in a Premature Infant with Hypoxic Ischemic Encephalopathy: A Case Report |
| title_full_unstemmed | Cardiac Dysfunction Associated with Lacosamide in a Premature Infant with Hypoxic Ischemic Encephalopathy: A Case Report |
| title_short | Cardiac Dysfunction Associated with Lacosamide in a Premature Infant with Hypoxic Ischemic Encephalopathy: A Case Report |
| title_sort | cardiac dysfunction associated with lacosamide in a premature infant with hypoxic ischemic encephalopathy a case report |
| topic | cardiac dysfunction antiseizure medication preterm infant lacosamide |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/a-2447-8662 |
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