Transcranial parenhymal sonography in the diagnosis of Parkinson's disease
Bacground/Aim. Modern ultrasound systems allow highresolution transcranial sonography (TCS) of the brain structures. Enlargement of the echogenic signal (hyperechogenicity) of the substantia nigra (SN) has been reported as a highly characteristic finding in idiopathic Parkinson's disease (PD) a...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2008-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2008/0042-84500808601M.pdf |
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| author | Mijajlović Milija Petrović Igor Stojković Tanja Svetel Marina Stefanova Elka Kostić Vladimir S. |
| author_facet | Mijajlović Milija Petrović Igor Stojković Tanja Svetel Marina Stefanova Elka Kostić Vladimir S. |
| author_sort | Mijajlović Milija |
| collection | DOAJ |
| description | Bacground/Aim. Modern ultrasound systems allow highresolution transcranial sonography (TCS) of the brain structures. Enlargement of the echogenic signal (hyperechogenicity) of the substantia nigra (SN) has been reported as a highly characteristic finding in idiopathic Parkinson's disease (PD) and is thought to reflect increased amounts of iron, bound to proteins other than ferritin, in the SN in the course of neurodegeneration. The aim of our study was to investigate the prevalence of the SN hyperechogenicity in PD patients, as well as its possible clinical correlates. Methods. The study comprised 103 consecutive PD patients and 50 healthy age-matched controls. For TCS examination a color-coded, phased array ultrasound system equipped with a 2.5 MHz transducer was used (ESAOTE Technos MP, Italia). The examination was performed through a preauricular acoustic bone window with a penetration depth of 16 cm and a dynamic range of 45-50 dB. The SN was identified within the butterfly shaped structure of the mesencephalic brainstem, with scanning from both temporal windows. Results. The SN hyperechogenicity was identified in 95 out of 103 examined PD patients (92%), which was marked in 60 (63%), and moderate in 35 patients (37%). Median SN echogenic size was larger contralateral to the clinically more affected side of the body. Unilateral SN hyperechogenicity was also found in 5 out of 50 healthy controls (10%). No ventricular enlargements were notified in our study. Conclusion. Our study demonstrated SN hyperechogenicity in more than 90% of PD patients. In adult subjects without neurological symptoms, the TCS finding of at least unilaterally marked SN hyperechogenicity indicates a subclinical functional impairment of the nigrostriatal dopaminergic system. . |
| format | Article |
| id | doaj-art-8014d38c57f042c88d3eafb8bcb6d5c3 |
| institution | Kabale University |
| issn | 0042-8450 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-8014d38c57f042c88d3eafb8bcb6d5c32025-08-20T03:35:14ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502008-01-0165860160510.2298/VSP0808601MTranscranial parenhymal sonography in the diagnosis of Parkinson's diseaseMijajlović MilijaPetrović IgorStojković TanjaSvetel MarinaStefanova ElkaKostić Vladimir S.Bacground/Aim. Modern ultrasound systems allow highresolution transcranial sonography (TCS) of the brain structures. Enlargement of the echogenic signal (hyperechogenicity) of the substantia nigra (SN) has been reported as a highly characteristic finding in idiopathic Parkinson's disease (PD) and is thought to reflect increased amounts of iron, bound to proteins other than ferritin, in the SN in the course of neurodegeneration. The aim of our study was to investigate the prevalence of the SN hyperechogenicity in PD patients, as well as its possible clinical correlates. Methods. The study comprised 103 consecutive PD patients and 50 healthy age-matched controls. For TCS examination a color-coded, phased array ultrasound system equipped with a 2.5 MHz transducer was used (ESAOTE Technos MP, Italia). The examination was performed through a preauricular acoustic bone window with a penetration depth of 16 cm and a dynamic range of 45-50 dB. The SN was identified within the butterfly shaped structure of the mesencephalic brainstem, with scanning from both temporal windows. Results. The SN hyperechogenicity was identified in 95 out of 103 examined PD patients (92%), which was marked in 60 (63%), and moderate in 35 patients (37%). Median SN echogenic size was larger contralateral to the clinically more affected side of the body. Unilateral SN hyperechogenicity was also found in 5 out of 50 healthy controls (10%). No ventricular enlargements were notified in our study. Conclusion. Our study demonstrated SN hyperechogenicity in more than 90% of PD patients. In adult subjects without neurological symptoms, the TCS finding of at least unilaterally marked SN hyperechogenicity indicates a subclinical functional impairment of the nigrostriatal dopaminergic system. .http://www.doiserbia.nb.rs/img/doi/0042-8450/2008/0042-84500808601M.pdfParkinson diseasediagnosisultrasonographydopplertranscranialsubstantia nigra |
| spellingShingle | Mijajlović Milija Petrović Igor Stojković Tanja Svetel Marina Stefanova Elka Kostić Vladimir S. Transcranial parenhymal sonography in the diagnosis of Parkinson's disease Vojnosanitetski Pregled Parkinson disease diagnosis ultrasonography doppler transcranial substantia nigra |
| title | Transcranial parenhymal sonography in the diagnosis of Parkinson's disease |
| title_full | Transcranial parenhymal sonography in the diagnosis of Parkinson's disease |
| title_fullStr | Transcranial parenhymal sonography in the diagnosis of Parkinson's disease |
| title_full_unstemmed | Transcranial parenhymal sonography in the diagnosis of Parkinson's disease |
| title_short | Transcranial parenhymal sonography in the diagnosis of Parkinson's disease |
| title_sort | transcranial parenhymal sonography in the diagnosis of parkinson s disease |
| topic | Parkinson disease diagnosis ultrasonography doppler transcranial substantia nigra |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2008/0042-84500808601M.pdf |
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