Proximity Labeling-Based Identification of MGAT3 Substrates and Revelation of the Tumor-Suppressive Role of Bisecting GlcNAc in Breast Cancer via GLA Degradation
Glycosylation plays a critical role in various biological processes, yet identifying specific glycosyltransferase substrates remains a challenge due to the complexity of glycosylation. Here, we employ proximity labeling with biotin ligases BASU and TurboID to map the proximitome of MGAT3, a glycosyl...
Saved in:
| Main Authors: | Bowen Wang, Xin He, Yue Zhou, Zengqi Tan, Xiang Li, Feng Guan, Lei Lei |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/14/2/103 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Bisecting GlcNAc enhances CD8+ T cell-mediated killing of breast cancer by suppressing PD-L1 expression and its binding to PD-1
by: Xueting Ren, et al.
Published: (2025-08-01) -
MSC-sEVs exacerbate senescence by transferring bisecting GlcNAcylated GPNMB
by: Yihan Ma, et al.
Published: (2025-01-01) -
An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease
by: Yasuhiko Kizuka, et al.
Published: (2015-01-01) -
Functional genomic profiling of O-GlcNAc reveals its context-specific interplay with RNA polymerase II
by: Sofia Rucli, et al.
Published: (2025-03-01) -
New perspectives on YTHDF2 O-GlcNAc modification in the pathogenesis of intervertebral disc degeneration
by: Liangjie Lu, et al.
Published: (2024-10-01)