Widening the histopathological tool kit in clear cell odontogenic carcinoma for precision diagnostics
Goal of the perspective: CCOC is a relatively uncommon malignant odontogenic tumor which presents with diagnostic challenges due to its perplexing histological patterns. It is critical to recognize this unusual tumor and distinguish it from other clear cell neoplasms in order to develop an effective...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024000359 |
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| author | Ramya Ramadoss Abigail Viola E Chitra Shivalingam |
| author_facet | Ramya Ramadoss Abigail Viola E Chitra Shivalingam |
| author_sort | Ramya Ramadoss |
| collection | DOAJ |
| description | Goal of the perspective: CCOC is a relatively uncommon malignant odontogenic tumor which presents with diagnostic challenges due to its perplexing histological patterns. It is critical to recognize this unusual tumor and distinguish it from other clear cell neoplasms in order to develop an effective treatment approach. Discussion: Tissue samples of clear cell odontogenic carcinoma were sourced from core, tumor permeated bone, semi permeated bone and unaffected bone. Validation with FT-IR revealed dominant phosphate in normal bone, increased amide groups in permeated bone and hydroxide group in core tissue. Conclusion: Routine histopathological assessment relies heavily on morphological alterations. Precise additional diagnostic tools like FTIR for effective ionic characterization are crucial to derive precision diagnostic and therapeutic strategies in lesions with enigmatic features. |
| format | Article |
| id | doaj-art-80100b41fb1748bd9b95fee60779a902 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-80100b41fb1748bd9b95fee60779a9022025-01-09T06:15:16ZengElsevierOral Oncology Reports2772-90602024-03-019100189Widening the histopathological tool kit in clear cell odontogenic carcinoma for precision diagnosticsRamya Ramadoss0Abigail Viola E1Chitra Shivalingam2Department of Oral Biology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600077, India; Corresponding author. Saveetha Dental College, Department Of Oral Biology, Saveetha University, Chennnai, 77, Tamilnadu, India.Department of Oral Pathology, SRM Dental College, SRM University, Chennai, 600089, IndiaDepartment of Prosthodontics, Saveetha Dental college, Saveetha Insitute of Medical and technical sciences, Saveetha University, Chennai, 600077, IndiaGoal of the perspective: CCOC is a relatively uncommon malignant odontogenic tumor which presents with diagnostic challenges due to its perplexing histological patterns. It is critical to recognize this unusual tumor and distinguish it from other clear cell neoplasms in order to develop an effective treatment approach. Discussion: Tissue samples of clear cell odontogenic carcinoma were sourced from core, tumor permeated bone, semi permeated bone and unaffected bone. Validation with FT-IR revealed dominant phosphate in normal bone, increased amide groups in permeated bone and hydroxide group in core tissue. Conclusion: Routine histopathological assessment relies heavily on morphological alterations. Precise additional diagnostic tools like FTIR for effective ionic characterization are crucial to derive precision diagnostic and therapeutic strategies in lesions with enigmatic features.http://www.sciencedirect.com/science/article/pii/S2772906024000359Clear cell odontogenic carcinomaClear cellOdontogenic carcinomaImmunohistochemistryFourier transform infrared spectroscopy |
| spellingShingle | Ramya Ramadoss Abigail Viola E Chitra Shivalingam Widening the histopathological tool kit in clear cell odontogenic carcinoma for precision diagnostics Oral Oncology Reports Clear cell odontogenic carcinoma Clear cell Odontogenic carcinoma Immunohistochemistry Fourier transform infrared spectroscopy |
| title | Widening the histopathological tool kit in clear cell odontogenic carcinoma for precision diagnostics |
| title_full | Widening the histopathological tool kit in clear cell odontogenic carcinoma for precision diagnostics |
| title_fullStr | Widening the histopathological tool kit in clear cell odontogenic carcinoma for precision diagnostics |
| title_full_unstemmed | Widening the histopathological tool kit in clear cell odontogenic carcinoma for precision diagnostics |
| title_short | Widening the histopathological tool kit in clear cell odontogenic carcinoma for precision diagnostics |
| title_sort | widening the histopathological tool kit in clear cell odontogenic carcinoma for precision diagnostics |
| topic | Clear cell odontogenic carcinoma Clear cell Odontogenic carcinoma Immunohistochemistry Fourier transform infrared spectroscopy |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024000359 |
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