Efficacy and Safety of Dead Sea-Derived Components in Oral Health Applications: A Systematic Review
The therapeutic potential of Dead Sea-derived components in oral health management has gained increasing attention, yet remains largely unexplored. This systematic review aimed to evaluate the efficacy and safety of Dead Sea-based products in oral health applications. A comprehensive literature sea...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2025-06-01
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| Series: | Traditional and Integrative Medicine |
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| Online Access: | https://jtim.tums.ac.ir/index.php/jtim/article/view/1754 |
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| author | Elisabetta Ferrara Giovanna Murmura Manlio Santilli Bruna Sinjari |
| author_facet | Elisabetta Ferrara Giovanna Murmura Manlio Santilli Bruna Sinjari |
| author_sort | Elisabetta Ferrara |
| collection | DOAJ |
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The therapeutic potential of Dead Sea-derived components in oral health management has gained increasing attention, yet remains largely unexplored. This systematic review aimed to evaluate the efficacy and safety of Dead Sea-based products in oral health applications. A comprehensive literature search was conducted in PubMed, Scopus, and Web of Science databases for studies published up to March 2023, yielding seven studies that met the inclusion criteria. The evidence suggests potential benefits of Dead Sea-derived products in managing periodontal conditions and chemotherapy-induced oral mucositis. Randomized controlled trials demonstrated that Dead Sea salt-containing mouthwashes significantly reduced plaque and gingival indices compared to controls, with efficacy comparable to chlorhexidine in some cases. An observational study reported reduced mucositis intensity in cancer patients using Dead Sea mineral products. In vitro research showed Dead Sea salt solutions reduced concentrations of bacterial leukotoxin, lipopolysaccharide endotoxin, and glucan sucrase. A clinical trial found significant reductions in salivary viral loads with a Dead Sea salt-based mouthwash. However, a Dead Sea salt-based tooth whitening regimen was less effective than conventional peroxide treatment. The unique mineral composition and microbiological characteristics of the Dead Sea appear to confer antimicrobial and anti-inflammatory properties. Nevertheless, the evidence is limited by the small number of studies, their heterogeneity, and lack of long-term follow-up data. Further research is needed to establish the long-term efficacy and safety of these products in oral health care.
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| format | Article |
| id | doaj-art-800ff3f30dda4f1685c356925f71dcb2 |
| institution | Kabale University |
| issn | 2476-5104 2476-5112 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Traditional and Integrative Medicine |
| spelling | doaj-art-800ff3f30dda4f1685c356925f71dcb22025-08-20T03:50:25ZengTehran University of Medical SciencesTraditional and Integrative Medicine2476-51042476-51122025-06-0110210.18502/tim.v10i2.19066Efficacy and Safety of Dead Sea-Derived Components in Oral Health Applications: A Systematic ReviewElisabetta Ferrara0Giovanna Murmura1Manlio Santilli2Bruna Sinjari3Department of Human Sciences, Law, and Economics, Telematic University Leonardo Da Vinci, “UNIDAV”, Torrevecchia Teatina, Chieti, ItalyDepartment of Innovative Technologies in Medicine and Dentistry, "G.D'Annunzio" University of Chieti-Pescara, Chieti, ItalyDepartment of Innovative Technologies in Medicine and Dentistry, "G.D'Annunzio" University of Chieti-Pescara, Chieti, ItalyDepartment of Innovative Technologies in Medicine and Dentistry, "G.D'Annunzio" University of Chieti-Pescara, Chieti, Italy The therapeutic potential of Dead Sea-derived components in oral health management has gained increasing attention, yet remains largely unexplored. This systematic review aimed to evaluate the efficacy and safety of Dead Sea-based products in oral health applications. A comprehensive literature search was conducted in PubMed, Scopus, and Web of Science databases for studies published up to March 2023, yielding seven studies that met the inclusion criteria. The evidence suggests potential benefits of Dead Sea-derived products in managing periodontal conditions and chemotherapy-induced oral mucositis. Randomized controlled trials demonstrated that Dead Sea salt-containing mouthwashes significantly reduced plaque and gingival indices compared to controls, with efficacy comparable to chlorhexidine in some cases. An observational study reported reduced mucositis intensity in cancer patients using Dead Sea mineral products. In vitro research showed Dead Sea salt solutions reduced concentrations of bacterial leukotoxin, lipopolysaccharide endotoxin, and glucan sucrase. A clinical trial found significant reductions in salivary viral loads with a Dead Sea salt-based mouthwash. However, a Dead Sea salt-based tooth whitening regimen was less effective than conventional peroxide treatment. The unique mineral composition and microbiological characteristics of the Dead Sea appear to confer antimicrobial and anti-inflammatory properties. Nevertheless, the evidence is limited by the small number of studies, their heterogeneity, and lack of long-term follow-up data. Further research is needed to establish the long-term efficacy and safety of these products in oral health care. https://jtim.tums.ac.ir/index.php/jtim/article/view/1754Dead Sea mineralsThermal watersOral health |
| spellingShingle | Elisabetta Ferrara Giovanna Murmura Manlio Santilli Bruna Sinjari Efficacy and Safety of Dead Sea-Derived Components in Oral Health Applications: A Systematic Review Traditional and Integrative Medicine Dead Sea minerals Thermal waters Oral health |
| title | Efficacy and Safety of Dead Sea-Derived Components in Oral Health Applications: A Systematic Review |
| title_full | Efficacy and Safety of Dead Sea-Derived Components in Oral Health Applications: A Systematic Review |
| title_fullStr | Efficacy and Safety of Dead Sea-Derived Components in Oral Health Applications: A Systematic Review |
| title_full_unstemmed | Efficacy and Safety of Dead Sea-Derived Components in Oral Health Applications: A Systematic Review |
| title_short | Efficacy and Safety of Dead Sea-Derived Components in Oral Health Applications: A Systematic Review |
| title_sort | efficacy and safety of dead sea derived components in oral health applications a systematic review |
| topic | Dead Sea minerals Thermal waters Oral health |
| url | https://jtim.tums.ac.ir/index.php/jtim/article/view/1754 |
| work_keys_str_mv | AT elisabettaferrara efficacyandsafetyofdeadseaderivedcomponentsinoralhealthapplicationsasystematicreview AT giovannamurmura efficacyandsafetyofdeadseaderivedcomponentsinoralhealthapplicationsasystematicreview AT manliosantilli efficacyandsafetyofdeadseaderivedcomponentsinoralhealthapplicationsasystematicreview AT brunasinjari efficacyandsafetyofdeadseaderivedcomponentsinoralhealthapplicationsasystematicreview |