Polymer Brushes: Novel Surfaces for Biomedical Applications
Polymer brushes play an important role in surface modification techniques to improve the biocompatibility of modified surfaces inside the human body for different biological and biomedical applications. This modification gives the ability to control biointerfacial interactions such as cell attachmen...
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| Format: | Article |
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College of Medicine, Al-Nahrain University
2023-09-01
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| Series: | Baghdad Journal of Biochemistry and Applied Biological Sciences |
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| Online Access: | https://www.bjbabs.org/index.php/bjbabs/article/view/260 |
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| author | Ahmed Al-Ani Emad Yousif |
| author_facet | Ahmed Al-Ani Emad Yousif |
| author_sort | Ahmed Al-Ani |
| collection | DOAJ |
| description | Polymer brushes play an important role in surface modification techniques to improve the biocompatibility of modified surfaces inside the human body for different biological and biomedical applications. This modification gives the ability to control biointerfacial interactions such as cell attachment, protein adsorption, and bacterial biofilm formation. Surface modification with polymer layers can be utilized to alter the surface properties, including biocompatibility, antifouling ability, corrosion resistance, and wettability, and it can be achieved by immobilization or spraying of polymers from solution. Also, it is easy to graft polymers with reactive end groups onto surfaces, leading to the formation of polymer brushes at high density, which have specific features, such as chemical robustness, tunable mechanical properties and the flexibility to use polymers of different chemistry or the introduction of bifunctional polymers for specific immobilization of other molecules, especially proteins and enzymes. The specific properties of polymer brushes make them ideal candidates to be used in the biomedical field. For example, polymer brushes can be synthesised on different substrates, particularly metallic and non-metallic surfaces. The technique is flexible in nature, which enables the terminal functional groups of the attached chains to be tailored with ligands for enhancing cell adhesion and proliferation while at the same time preventing non-specific adsorption of other proteins. In addition, Due to interfacial attachment to biomaterials, polymer brushes can be designed to encourage cells to attach and grow through simple modification and conjugation processes, finding applications in drug delivery, implants and tissue engineering Polymer brushes play an important role in surface modification techniques to improve the biocompatibility of modified surfaces inside the human body for different biological and biomedical applications. This modification gives the ability to control biointerfacial interactions, such as cell attachment, protein adsorption, and bacterial biofilm formation. Surface modification with polymer layers can be utilised to alter the surface properties, including biocompatibility, antifouling ability, corrosion resistance, and wettability, and it can be achieved by immobilisation or spraying of polymers from solution. Also, it is easy to graft polymers with reactive end groups onto surfaces, leading to the formation of polymer brushes at high density, which have specific features, such as chemical robustness, tunable mechanical properties and the flexibility to use polymers of different chemistry or the introduction of bifunctional polymers for specific immobilisation of other molecules, especially proteins and enzymes. The specific properties of polymer brushes make them ideal candidates to be used in the biomedical field. For example, polymer brushes can be synthesised on different substrates, particularly metallic and non-metallic surfaces. The technique is flexible, which enables the terminal functional groups of the attached chains to be tailored with ligands for enhancing cell adhesion and proliferation while at the same time preventing non-specific adsorption of other proteins. In addition, due to interfacial attachment to biomaterials, polymer brushes can be designed to encourage cells to attach and grow through simple modification and conjugation processes, finding applications in drug delivery, implants and tissue engineering. |
| format | Article |
| id | doaj-art-800dc72f3b9d4b4bb91e0625a1a3b22e |
| institution | DOAJ |
| issn | 2706-9915 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | College of Medicine, Al-Nahrain University |
| record_format | Article |
| series | Baghdad Journal of Biochemistry and Applied Biological Sciences |
| spelling | doaj-art-800dc72f3b9d4b4bb91e0625a1a3b22e2025-08-20T03:16:39ZengCollege of Medicine, Al-Nahrain UniversityBaghdad Journal of Biochemistry and Applied Biological Sciences2706-99152023-09-01439910110.47419/bjbabs.v4i03.260Polymer Brushes: Novel Surfaces for Biomedical ApplicationsAhmed Al-Ani0https://orcid.org/0000-0002-7517-7447Emad Yousif1https://orcid.org/0000-0003-1458-4724Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, IraqDepartment of Chemistry, College of Science, Al-Nahrain University, Baghdad, IraqPolymer brushes play an important role in surface modification techniques to improve the biocompatibility of modified surfaces inside the human body for different biological and biomedical applications. This modification gives the ability to control biointerfacial interactions such as cell attachment, protein adsorption, and bacterial biofilm formation. Surface modification with polymer layers can be utilized to alter the surface properties, including biocompatibility, antifouling ability, corrosion resistance, and wettability, and it can be achieved by immobilization or spraying of polymers from solution. Also, it is easy to graft polymers with reactive end groups onto surfaces, leading to the formation of polymer brushes at high density, which have specific features, such as chemical robustness, tunable mechanical properties and the flexibility to use polymers of different chemistry or the introduction of bifunctional polymers for specific immobilization of other molecules, especially proteins and enzymes. The specific properties of polymer brushes make them ideal candidates to be used in the biomedical field. For example, polymer brushes can be synthesised on different substrates, particularly metallic and non-metallic surfaces. The technique is flexible in nature, which enables the terminal functional groups of the attached chains to be tailored with ligands for enhancing cell adhesion and proliferation while at the same time preventing non-specific adsorption of other proteins. In addition, Due to interfacial attachment to biomaterials, polymer brushes can be designed to encourage cells to attach and grow through simple modification and conjugation processes, finding applications in drug delivery, implants and tissue engineering Polymer brushes play an important role in surface modification techniques to improve the biocompatibility of modified surfaces inside the human body for different biological and biomedical applications. This modification gives the ability to control biointerfacial interactions, such as cell attachment, protein adsorption, and bacterial biofilm formation. Surface modification with polymer layers can be utilised to alter the surface properties, including biocompatibility, antifouling ability, corrosion resistance, and wettability, and it can be achieved by immobilisation or spraying of polymers from solution. Also, it is easy to graft polymers with reactive end groups onto surfaces, leading to the formation of polymer brushes at high density, which have specific features, such as chemical robustness, tunable mechanical properties and the flexibility to use polymers of different chemistry or the introduction of bifunctional polymers for specific immobilisation of other molecules, especially proteins and enzymes. The specific properties of polymer brushes make them ideal candidates to be used in the biomedical field. For example, polymer brushes can be synthesised on different substrates, particularly metallic and non-metallic surfaces. The technique is flexible, which enables the terminal functional groups of the attached chains to be tailored with ligands for enhancing cell adhesion and proliferation while at the same time preventing non-specific adsorption of other proteins. In addition, due to interfacial attachment to biomaterials, polymer brushes can be designed to encourage cells to attach and grow through simple modification and conjugation processes, finding applications in drug delivery, implants and tissue engineering.https://www.bjbabs.org/index.php/bjbabs/article/view/260polymer brushesprotein adsorptiontissue engineering |
| spellingShingle | Ahmed Al-Ani Emad Yousif Polymer Brushes: Novel Surfaces for Biomedical Applications Baghdad Journal of Biochemistry and Applied Biological Sciences polymer brushes protein adsorption tissue engineering |
| title | Polymer Brushes: Novel Surfaces for Biomedical Applications |
| title_full | Polymer Brushes: Novel Surfaces for Biomedical Applications |
| title_fullStr | Polymer Brushes: Novel Surfaces for Biomedical Applications |
| title_full_unstemmed | Polymer Brushes: Novel Surfaces for Biomedical Applications |
| title_short | Polymer Brushes: Novel Surfaces for Biomedical Applications |
| title_sort | polymer brushes novel surfaces for biomedical applications |
| topic | polymer brushes protein adsorption tissue engineering |
| url | https://www.bjbabs.org/index.php/bjbabs/article/view/260 |
| work_keys_str_mv | AT ahmedalani polymerbrushesnovelsurfacesforbiomedicalapplications AT emadyousif polymerbrushesnovelsurfacesforbiomedicalapplications |