Longitudinal assessment of the association between pesticide exposure and lifestyle with Parkinson’s disease motor severity
Abstract Longitudinal investigations on the relationship between lifestyle exposures and motor severity are lacking. In this longitudinal study, we included patients with idiopathic Parkinson’s disease (iPD) (N = 5139) and LRRK2-related PD (N = 81) from PPMI-Online and Fox Insight. Motor aspects wer...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-06-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-01010-2 |
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| author | Theresa Lüth Amke Caliebe Carolin Gabbert Sebastian Sendel Björn-Hergen Laabs Inke R. König Christine Klein Joanne Trinh |
| author_facet | Theresa Lüth Amke Caliebe Carolin Gabbert Sebastian Sendel Björn-Hergen Laabs Inke R. König Christine Klein Joanne Trinh |
| author_sort | Theresa Lüth |
| collection | DOAJ |
| description | Abstract Longitudinal investigations on the relationship between lifestyle exposures and motor severity are lacking. In this longitudinal study, we included patients with idiopathic Parkinson’s disease (iPD) (N = 5139) and LRRK2-related PD (N = 81) from PPMI-Online and Fox Insight. Motor aspects were followed for up to five years. We investigated the association between environmental exposure, lifestyle factors and motor aspect severity over time by applying linear mixed effects models. In LRRK2-PD, black tea consumption was associated with less severe motor aspects (β = −0.51, p = 0.028). In patients with iPD, pesticide exposure was associated with more severe motor aspects over time in PPMI-Online (β = 0.23, p = 3.56 × 10− 9). Lastly, caffeinated soda was associated with more severe motor aspects in patients with iPD from PPMI-Online (β = 0.15, p = 3.84 × 10−8) and Fox Insight (β = 0.09, p = 0.031). We suggest that pesticide exposure and lifestyle factors may affect motor severity in patients with LRRK2-PD and iPD, demonstrating the impact on patients even after disease onset. |
| format | Article |
| id | doaj-art-8007b6fbd05945789f7edede431fc454 |
| institution | DOAJ |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-8007b6fbd05945789f7edede431fc4542025-08-20T03:21:02ZengNature Portfolionpj Parkinson's Disease2373-80572025-06-0111111310.1038/s41531-025-01010-2Longitudinal assessment of the association between pesticide exposure and lifestyle with Parkinson’s disease motor severityTheresa Lüth0Amke Caliebe1Carolin Gabbert2Sebastian Sendel3Björn-Hergen Laabs4Inke R. König5Christine Klein6Joanne Trinh7Institute of Neurogenetics, University of LübeckInstitute of Medical Informatics and Statistics, Kiel University and University Hospital Schleswig-HolsteinInstitute of Neurogenetics, University of LübeckInstitute of Medical Informatics and Statistics, Kiel University and University Hospital Schleswig-HolsteinInstitute of Medical Biometry and Statistics, University of LübeckInstitute of Medical Biometry and Statistics, University of LübeckInstitute of Neurogenetics, University of LübeckInstitute of Neurogenetics, University of LübeckAbstract Longitudinal investigations on the relationship between lifestyle exposures and motor severity are lacking. In this longitudinal study, we included patients with idiopathic Parkinson’s disease (iPD) (N = 5139) and LRRK2-related PD (N = 81) from PPMI-Online and Fox Insight. Motor aspects were followed for up to five years. We investigated the association between environmental exposure, lifestyle factors and motor aspect severity over time by applying linear mixed effects models. In LRRK2-PD, black tea consumption was associated with less severe motor aspects (β = −0.51, p = 0.028). In patients with iPD, pesticide exposure was associated with more severe motor aspects over time in PPMI-Online (β = 0.23, p = 3.56 × 10− 9). Lastly, caffeinated soda was associated with more severe motor aspects in patients with iPD from PPMI-Online (β = 0.15, p = 3.84 × 10−8) and Fox Insight (β = 0.09, p = 0.031). We suggest that pesticide exposure and lifestyle factors may affect motor severity in patients with LRRK2-PD and iPD, demonstrating the impact on patients even after disease onset.https://doi.org/10.1038/s41531-025-01010-2 |
| spellingShingle | Theresa Lüth Amke Caliebe Carolin Gabbert Sebastian Sendel Björn-Hergen Laabs Inke R. König Christine Klein Joanne Trinh Longitudinal assessment of the association between pesticide exposure and lifestyle with Parkinson’s disease motor severity npj Parkinson's Disease |
| title | Longitudinal assessment of the association between pesticide exposure and lifestyle with Parkinson’s disease motor severity |
| title_full | Longitudinal assessment of the association between pesticide exposure and lifestyle with Parkinson’s disease motor severity |
| title_fullStr | Longitudinal assessment of the association between pesticide exposure and lifestyle with Parkinson’s disease motor severity |
| title_full_unstemmed | Longitudinal assessment of the association between pesticide exposure and lifestyle with Parkinson’s disease motor severity |
| title_short | Longitudinal assessment of the association between pesticide exposure and lifestyle with Parkinson’s disease motor severity |
| title_sort | longitudinal assessment of the association between pesticide exposure and lifestyle with parkinson s disease motor severity |
| url | https://doi.org/10.1038/s41531-025-01010-2 |
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