Emergence of extensively drug-resistant Salmonella Kentucky ST198 in Southwest China
Objectives: The study aimed to investigate the prevalence, antimicrobial resistance profiles, and virulence characteristics of Salmonella isolates from clinical cases in Sichuan, China, collected from 2019 to 2021. Methods: A total of 153 Salmonella isolates from 19 regions in Sichuan Province were...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | Journal of Global Antimicrobial Resistance |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716525001134 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Objectives: The study aimed to investigate the prevalence, antimicrobial resistance profiles, and virulence characteristics of Salmonella isolates from clinical cases in Sichuan, China, collected from 2019 to 2021. Methods: A total of 153 Salmonella isolates from 19 regions in Sichuan Province were analysed. Sequence types (STs) were identified using multi-locus sequence typing. Antimicrobial susceptibility testing was conducted to assess resistance profiles, while whole-genome sequencing was used to detect antimicrobial resistance genes (ARGs) and virulence genes. Results: Among the 153 Salmonella isolates, 49 STs were identified. ST11 (S. Enteritidis) was the most prevalent, while S. Kentucky comprised 3.27% (5/153) of isolates, significantly higher than the national average (0.33%, P < 0.05). All S. Kentucky ST198 isolates were extensively drug-resistant, exhibiting resistance to at least seven antimicrobial classes, including fluoroquinolones and extended-spectrum cephalosporins. S. Kentucky ST198 harboured significantly more ARGs (P < 0.001) and virulence genes (P < 0.001) than other strains. ARGs such as CTX-M-55, TEM-216, TEM-90, and TEM-150 were significantly more prevalent (P < 0.05), conferring resistance to extended-spectrum cephalosporins and β-lactams. Additionally, the absence of sifA (16.7% vs. 91.8%, P < 0.001) and shdA (0.0% vs. 68.7%, P = 0.001), suggesting that these genes may influence the reduced risk of human infection by ST198. Conclusions: These findings highlight the emergence of extensively drug-resistant Salmonella Kentucky ST198 in Southwest China and underscore the urgent need for ongoing surveillance in this region due to its significant public health impact. |
|---|---|
| ISSN: | 2213-7165 |