Synthesis and Antimicrobial Evaluation of New 1,2,4-Triazolo[1,5‑a]pyrimidine-Based Derivatives as Dual Inhibitors of Bacterial DNA Gyrase and DHFR
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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American Chemical Society
2024-11-01
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| Series: | ACS Omega |
| Online Access: | https://doi.org/10.1021/acsomega.4c08365 |
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| author | Lamya H. Al-Wahaibi Safwat M. Rabea Mohamed A. Mahmoud Bahaa G.M. Youssif Stefan Bräse Salah A. Abdel-Aziz |
| author_facet | Lamya H. Al-Wahaibi Safwat M. Rabea Mohamed A. Mahmoud Bahaa G.M. Youssif Stefan Bräse Salah A. Abdel-Aziz |
| author_sort | Lamya H. Al-Wahaibi |
| collection | DOAJ |
| format | Article |
| id | doaj-art-80022fef9d814c61918ef55c92d96e5c |
| institution | DOAJ |
| issn | 2470-1343 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | American Chemical Society |
| record_format | Article |
| series | ACS Omega |
| spelling | doaj-art-80022fef9d814c61918ef55c92d96e5c2025-08-20T02:48:12ZengAmerican Chemical SocietyACS Omega2470-13432024-11-01947472614727310.1021/acsomega.4c08365Synthesis and Antimicrobial Evaluation of New 1,2,4-Triazolo[1,5‑a]pyrimidine-Based Derivatives as Dual Inhibitors of Bacterial DNA Gyrase and DHFRLamya H. Al-Wahaibi0Safwat M. Rabea1Mohamed A. Mahmoud2Bahaa G.M. Youssif3Stefan Bräse4Salah A. Abdel-Aziz5Department of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi ArabiaMedicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia, EgyptDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut, EgyptDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut, EgyptInstitute of Biological and Chemical Systems, IBCS-FMS, Karlsruhe Institute of Technology, Karlsruhe, GermanyDepartment of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Boys), Al-Azhar University, Assiut, Egypthttps://doi.org/10.1021/acsomega.4c08365 |
| spellingShingle | Lamya H. Al-Wahaibi Safwat M. Rabea Mohamed A. Mahmoud Bahaa G.M. Youssif Stefan Bräse Salah A. Abdel-Aziz Synthesis and Antimicrobial Evaluation of New 1,2,4-Triazolo[1,5‑a]pyrimidine-Based Derivatives as Dual Inhibitors of Bacterial DNA Gyrase and DHFR ACS Omega |
| title | Synthesis and Antimicrobial Evaluation of New 1,2,4-Triazolo[1,5‑a]pyrimidine-Based Derivatives as Dual Inhibitors of Bacterial DNA Gyrase and DHFR |
| title_full | Synthesis and Antimicrobial Evaluation of New 1,2,4-Triazolo[1,5‑a]pyrimidine-Based Derivatives as Dual Inhibitors of Bacterial DNA Gyrase and DHFR |
| title_fullStr | Synthesis and Antimicrobial Evaluation of New 1,2,4-Triazolo[1,5‑a]pyrimidine-Based Derivatives as Dual Inhibitors of Bacterial DNA Gyrase and DHFR |
| title_full_unstemmed | Synthesis and Antimicrobial Evaluation of New 1,2,4-Triazolo[1,5‑a]pyrimidine-Based Derivatives as Dual Inhibitors of Bacterial DNA Gyrase and DHFR |
| title_short | Synthesis and Antimicrobial Evaluation of New 1,2,4-Triazolo[1,5‑a]pyrimidine-Based Derivatives as Dual Inhibitors of Bacterial DNA Gyrase and DHFR |
| title_sort | synthesis and antimicrobial evaluation of new 1 2 4 triazolo 1 5 a pyrimidine based derivatives as dual inhibitors of bacterial dna gyrase and dhfr |
| url | https://doi.org/10.1021/acsomega.4c08365 |
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