Association of systemic immune-inflammation index with all-cause and cardiovascular mortality among adults with depression: evidence from NHANES 2005–2018
Abstract Background The relationship between the systemic immune-inflammatory index (SII) and the mortality of adults with depression is uncertain. Methods This study included adults with depression who were surveyed in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018....
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-024-06463-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841544367693627392 |
|---|---|
| author | Xinping Yu Heqing Zheng Mingxu Liu Lanxiang Wu Sheng Tian Wei Wu |
| author_facet | Xinping Yu Heqing Zheng Mingxu Liu Lanxiang Wu Sheng Tian Wei Wu |
| author_sort | Xinping Yu |
| collection | DOAJ |
| description | Abstract Background The relationship between the systemic immune-inflammatory index (SII) and the mortality of adults with depression is uncertain. Methods This study included adults with depression who were surveyed in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. Cox proportional hazards regression models to compute hazard ratios (HR) and 95% confidence intervals (CI) for mortality.The restricted cubic spline(RCS), Kaplan-Meier curve analysis, time-dependent ROC analysis, subgroup and sensitivity analyses were also used. Results A total of 2442 adults with depression were included in the final analysis(average age: 46.51 ± 0.44 years). During a median follow-up of 89 months, there were 302 all-cause deaths and 74 cardiovascular deaths. The fully adjusted model showed that an increment of 100 unit in SII corresponded to an increased HR of 1.05(95% CI,1.02,1.08, p = 0.003) for all-cause mortality and 1.06(95% CI,1.02,1.10, p = 0.004) for cardiovascular mortality, respectively. The RCS analysis indicated a J-shape relationship between SII and all-cause mortality and a positive linear association between SII and cardiovascular mortality.The time-dependent ROC analysis exhibited excellent efficacy in SII for predicting all-cause and cardiovascular mortality at 1, 3, 5 and 10 years. Conclusions Higher SII levels were associated with increased risk of all-cause and cardiovascular mortality in adults with depression. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-7fff642204b240cda6a7f89653839e78 |
| institution | Kabale University |
| issn | 1471-244X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj-art-7fff642204b240cda6a7f89653839e782025-01-12T12:34:20ZengBMCBMC Psychiatry1471-244X2025-01-0125111310.1186/s12888-024-06463-yAssociation of systemic immune-inflammation index with all-cause and cardiovascular mortality among adults with depression: evidence from NHANES 2005–2018Xinping Yu0Heqing Zheng1Mingxu Liu2Lanxiang Wu3Sheng Tian4Wei Wu5Department of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityAbstract Background The relationship between the systemic immune-inflammatory index (SII) and the mortality of adults with depression is uncertain. Methods This study included adults with depression who were surveyed in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. Cox proportional hazards regression models to compute hazard ratios (HR) and 95% confidence intervals (CI) for mortality.The restricted cubic spline(RCS), Kaplan-Meier curve analysis, time-dependent ROC analysis, subgroup and sensitivity analyses were also used. Results A total of 2442 adults with depression were included in the final analysis(average age: 46.51 ± 0.44 years). During a median follow-up of 89 months, there were 302 all-cause deaths and 74 cardiovascular deaths. The fully adjusted model showed that an increment of 100 unit in SII corresponded to an increased HR of 1.05(95% CI,1.02,1.08, p = 0.003) for all-cause mortality and 1.06(95% CI,1.02,1.10, p = 0.004) for cardiovascular mortality, respectively. The RCS analysis indicated a J-shape relationship between SII and all-cause mortality and a positive linear association between SII and cardiovascular mortality.The time-dependent ROC analysis exhibited excellent efficacy in SII for predicting all-cause and cardiovascular mortality at 1, 3, 5 and 10 years. Conclusions Higher SII levels were associated with increased risk of all-cause and cardiovascular mortality in adults with depression. Clinical trial number Not applicable.https://doi.org/10.1186/s12888-024-06463-ySystemic immune-inflammation indexDepressionCardiovascularMortalityCohort study |
| spellingShingle | Xinping Yu Heqing Zheng Mingxu Liu Lanxiang Wu Sheng Tian Wei Wu Association of systemic immune-inflammation index with all-cause and cardiovascular mortality among adults with depression: evidence from NHANES 2005–2018 BMC Psychiatry Systemic immune-inflammation index Depression Cardiovascular Mortality Cohort study |
| title | Association of systemic immune-inflammation index with all-cause and cardiovascular mortality among adults with depression: evidence from NHANES 2005–2018 |
| title_full | Association of systemic immune-inflammation index with all-cause and cardiovascular mortality among adults with depression: evidence from NHANES 2005–2018 |
| title_fullStr | Association of systemic immune-inflammation index with all-cause and cardiovascular mortality among adults with depression: evidence from NHANES 2005–2018 |
| title_full_unstemmed | Association of systemic immune-inflammation index with all-cause and cardiovascular mortality among adults with depression: evidence from NHANES 2005–2018 |
| title_short | Association of systemic immune-inflammation index with all-cause and cardiovascular mortality among adults with depression: evidence from NHANES 2005–2018 |
| title_sort | association of systemic immune inflammation index with all cause and cardiovascular mortality among adults with depression evidence from nhanes 2005 2018 |
| topic | Systemic immune-inflammation index Depression Cardiovascular Mortality Cohort study |
| url | https://doi.org/10.1186/s12888-024-06463-y |
| work_keys_str_mv | AT xinpingyu associationofsystemicimmuneinflammationindexwithallcauseandcardiovascularmortalityamongadultswithdepressionevidencefromnhanes20052018 AT heqingzheng associationofsystemicimmuneinflammationindexwithallcauseandcardiovascularmortalityamongadultswithdepressionevidencefromnhanes20052018 AT mingxuliu associationofsystemicimmuneinflammationindexwithallcauseandcardiovascularmortalityamongadultswithdepressionevidencefromnhanes20052018 AT lanxiangwu associationofsystemicimmuneinflammationindexwithallcauseandcardiovascularmortalityamongadultswithdepressionevidencefromnhanes20052018 AT shengtian associationofsystemicimmuneinflammationindexwithallcauseandcardiovascularmortalityamongadultswithdepressionevidencefromnhanes20052018 AT weiwu associationofsystemicimmuneinflammationindexwithallcauseandcardiovascularmortalityamongadultswithdepressionevidencefromnhanes20052018 |