Molecular typing and clinical characteristics of Clostridioides difficile infection in patients with inflammatory bowel disease: A retrospective study
Objectives: The increasing incidence of Clostridioides difficile infection (CDI) has been associated with poorer prognosis of patients with inflammatory bowel disease (IBD). However, relevant data are limited in China. The aim of this study was to clarify the molecular types and clinical characteris...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | Journal of Global Antimicrobial Resistance |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716525000839 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849473249316962304 |
|---|---|
| author | Jiayiren Li Jing Yang Zirou Ouyang Minghui Ren Jianhong Zhao |
| author_facet | Jiayiren Li Jing Yang Zirou Ouyang Minghui Ren Jianhong Zhao |
| author_sort | Jiayiren Li |
| collection | DOAJ |
| description | Objectives: The increasing incidence of Clostridioides difficile infection (CDI) has been associated with poorer prognosis of patients with inflammatory bowel disease (IBD). However, relevant data are limited in China. The aim of this study was to clarify the molecular types and clinical characteristics of C. difficile in IBD patients in China. Methods: Stool samples were collected, cultured anaerobically, and tested for glutamate dehydrogenase and C. difficile toxins A and B. Toxigenic C. difficile isolates were subjected to multi-locus sequence typing and antimicrobial susceptibility testing. Clinical data were collected to compare IBD and non-IBD patients with CDI, and to determine the risk factors associated with CDI in IBD patients. Results: The incidence of CDI was significantly higher in IBD patients than non-IBD patients (27.2% vs. 9.0%, respectively). Among IBD patients, the dominant sequence types (STs) were ST54 (20.2%), ST2 (14.9%), ST3 (14.9%), and ST42 (13.2%). The STs with the highest multidrug resistance rates were ST37 (100%), ST35 (100%), and ST42 (73.3%). In IBD patients, hospitalization within 6 months and use of 5-aminosalicylic acid were independent risk factors for CDI. Other risk factors included the use of proton pump inhibitors, immunosuppressants, and corticosteroids. Conclusion: The incidence of CDI was significantly higher in IBD patients than non-IBD patients. Surveillance of CDI in hospitalized patients should be strengthened to reduce the incidence of CDI in IBD patients. |
| format | Article |
| id | doaj-art-7ffd32bad61f4441875c945ede2cbb90 |
| institution | Kabale University |
| issn | 2213-7165 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj-art-7ffd32bad61f4441875c945ede2cbb902025-08-20T03:24:12ZengElsevierJournal of Global Antimicrobial Resistance2213-71652025-06-014318819710.1016/j.jgar.2025.04.011Molecular typing and clinical characteristics of Clostridioides difficile infection in patients with inflammatory bowel disease: A retrospective studyJiayiren Li0Jing Yang1Zirou Ouyang2Minghui Ren3Jianhong Zhao4Hebei Provincial Center for Clinical Laboratories, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaHebei Provincial Center for Clinical Laboratories, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaHebei Provincial Center for Clinical Laboratories, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang, ChinaHebei Provincial Center for Clinical Laboratories, The Second Hospital of Hebei Medical University, Shijiazhuang, China; Corresponding author. Mailing address: 215 Hepingxi Road, Shijiazhuang city, Hebei Province, 050000, China.Objectives: The increasing incidence of Clostridioides difficile infection (CDI) has been associated with poorer prognosis of patients with inflammatory bowel disease (IBD). However, relevant data are limited in China. The aim of this study was to clarify the molecular types and clinical characteristics of C. difficile in IBD patients in China. Methods: Stool samples were collected, cultured anaerobically, and tested for glutamate dehydrogenase and C. difficile toxins A and B. Toxigenic C. difficile isolates were subjected to multi-locus sequence typing and antimicrobial susceptibility testing. Clinical data were collected to compare IBD and non-IBD patients with CDI, and to determine the risk factors associated with CDI in IBD patients. Results: The incidence of CDI was significantly higher in IBD patients than non-IBD patients (27.2% vs. 9.0%, respectively). Among IBD patients, the dominant sequence types (STs) were ST54 (20.2%), ST2 (14.9%), ST3 (14.9%), and ST42 (13.2%). The STs with the highest multidrug resistance rates were ST37 (100%), ST35 (100%), and ST42 (73.3%). In IBD patients, hospitalization within 6 months and use of 5-aminosalicylic acid were independent risk factors for CDI. Other risk factors included the use of proton pump inhibitors, immunosuppressants, and corticosteroids. Conclusion: The incidence of CDI was significantly higher in IBD patients than non-IBD patients. Surveillance of CDI in hospitalized patients should be strengthened to reduce the incidence of CDI in IBD patients.http://www.sciencedirect.com/science/article/pii/S2213716525000839Clostridioides difficileInflammatory bowel diseaseMultidrug resistanceRisk factors |
| spellingShingle | Jiayiren Li Jing Yang Zirou Ouyang Minghui Ren Jianhong Zhao Molecular typing and clinical characteristics of Clostridioides difficile infection in patients with inflammatory bowel disease: A retrospective study Journal of Global Antimicrobial Resistance Clostridioides difficile Inflammatory bowel disease Multidrug resistance Risk factors |
| title | Molecular typing and clinical characteristics of Clostridioides difficile infection in patients with inflammatory bowel disease: A retrospective study |
| title_full | Molecular typing and clinical characteristics of Clostridioides difficile infection in patients with inflammatory bowel disease: A retrospective study |
| title_fullStr | Molecular typing and clinical characteristics of Clostridioides difficile infection in patients with inflammatory bowel disease: A retrospective study |
| title_full_unstemmed | Molecular typing and clinical characteristics of Clostridioides difficile infection in patients with inflammatory bowel disease: A retrospective study |
| title_short | Molecular typing and clinical characteristics of Clostridioides difficile infection in patients with inflammatory bowel disease: A retrospective study |
| title_sort | molecular typing and clinical characteristics of clostridioides difficile infection in patients with inflammatory bowel disease a retrospective study |
| topic | Clostridioides difficile Inflammatory bowel disease Multidrug resistance Risk factors |
| url | http://www.sciencedirect.com/science/article/pii/S2213716525000839 |
| work_keys_str_mv | AT jiayirenli moleculartypingandclinicalcharacteristicsofclostridioidesdifficileinfectioninpatientswithinflammatoryboweldiseasearetrospectivestudy AT jingyang moleculartypingandclinicalcharacteristicsofclostridioidesdifficileinfectioninpatientswithinflammatoryboweldiseasearetrospectivestudy AT zirououyang moleculartypingandclinicalcharacteristicsofclostridioidesdifficileinfectioninpatientswithinflammatoryboweldiseasearetrospectivestudy AT minghuiren moleculartypingandclinicalcharacteristicsofclostridioidesdifficileinfectioninpatientswithinflammatoryboweldiseasearetrospectivestudy AT jianhongzhao moleculartypingandclinicalcharacteristicsofclostridioidesdifficileinfectioninpatientswithinflammatoryboweldiseasearetrospectivestudy |