Factors affecting the effectiveness of vitamin D supplementation
Background. Due to the prevalence of vitamin D insufficient supply of the population and its pleiotropic effect, optimization of vitamin D status is beyond doubt.Objective. The purpose of the review is to compare the effectiveness of taking different vitamers, doses, regimens and formulations of vit...
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| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Open Systems Publication
2024-05-01
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| Series: | Лечащий Врач |
| Subjects: | |
| Online Access: | https://journal.lvrach.ru/jour/article/view/1241 |
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| Summary: | Background. Due to the prevalence of vitamin D insufficient supply of the population and its pleiotropic effect, optimization of vitamin D status is beyond doubt.Objective. The purpose of the review is to compare the effectiveness of taking different vitamers, doses, regimens and formulations of vitamin D to optimize vitamin status and manifest pleiotropic effects.Results. An analysis of the literature revealed a general pattern: smaller doses require longer administration to achieve normal blood plasma 25(ОН)D levels. When taken regularly over a period of 3 to 6 months, doses corresponding to physiological needs will provide sufficient blood serum levels of 25(ОН)D. To obtain maximum benefit, a daily, continuous supply of daily vitamin D in doses of 800-1000 IU is preferable to intermittent bolus doses. The effectiveness of vitamin D depends on the form (oil, micellar, liposomes, etc.). After stopping the additional intake, "washing out" occurs, i.e. after 8-12 weeks, return to the original vitamin D supply. To maintain a normal blood serum level of 25(ОН)D and, accordingly, to have a positive effect on metabolic blood parameters, it is sufficient for healthy people to take vitamin D in a dose close to the age-related physiological requirement – 400-1000 IU/day. Persons taking glucocorticoids, suffering from osteoporosis, diabetes mellitus, obesity (especially after bariatric surgery) require higher doses of vitamins from 2000 to 5000 IU/day.Conclusion. The main parameters influencing the effectiveness of vitamin D are the vitamer used, the dose, duration and regimen of administration, and the form of release. To achieve an adequate supply with vitamin D and the manifestation of pleiotropic effects, patients require higher doses than healthy individuals. |
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| ISSN: | 1560-5175 2687-1181 |