Features of Staphylococcus Aureus Antibiotic Sensitivity in Children with Atopic Dermatitis
Background. Excessive colonization of the skin by various bacteria and fungi can be noted in patients with atopic dermatitis (AD), and the prevalence of secondary infection complications 30–48%. Several studies have shown that Staphylococcus aureus colonization is 60–100% in patients with AD compare...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2023-11-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/3301 |
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| author | Nikolay N. Murashkin Alexander I. Materikin Roman V. Epishev Maria A. Leonova Leonid A. Opryatin Roman A. Ivanov Alena A. Savelova |
| author_facet | Nikolay N. Murashkin Alexander I. Materikin Roman V. Epishev Maria A. Leonova Leonid A. Opryatin Roman A. Ivanov Alena A. Savelova |
| author_sort | Nikolay N. Murashkin |
| collection | DOAJ |
| description | Background. Excessive colonization of the skin by various bacteria and fungi can be noted in patients with atopic dermatitis (AD), and the prevalence of secondary infection complications 30–48%. Several studies have shown that Staphylococcus aureus colonization is 60–100% in patients with AD compared to 5–30% in healthy persons from the control group. Moreover, the incidence of methicillinresistant Staphylococcus aureus (MRSA) isolates is up to 10–30% in skin cultures at AD, according to experts. Therapy of AD complicated by secondary infection is one of the crucial challenges of modern dermatology. Mupirocin can be considered as one of the most effective topical antibiotic among others used for etiotropic therapy of infectious complications in AD patients, and it has been confirmed by numerous clinical studies.Conclusion. Staphylococcus aureus is the most common trigger of AD aggravation. MRSA in AD complicated by secondary infection is difficult to manage as it becomes resistant to many types of antibiotics; however, it shows persistent sensitivity to mupirocin. Mupirocin-based (2%) external agent is the most effective, safe, and preferred therapy variant for AD complicated by secondary infection in pediatrics. |
| format | Article |
| id | doaj-art-7ffa30c6e4654d969d105c277a3ceaa8 |
| institution | Kabale University |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj-art-7ffa30c6e4654d969d105c277a3ceaa82025-08-20T03:59:53Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352023-11-0122540040510.15690/vsp.v22i5.26402124Features of Staphylococcus Aureus Antibiotic Sensitivity in Children with Atopic DermatitisNikolay N. Murashkin0Alexander I. Materikin1Roman V. Epishev2Maria A. Leonova3Leonid A. Opryatin4Roman A. Ivanov5Alena A. Savelova6National Medical Research Center of Children’s Health; Sechenov First Moscow State Medical University; Central State Medical Academy of Department of Presidential AffairsNational Medical Research Center of Children’s HealthNational Medical Research Center of Children’s HealthNational Medical Research Center of Children’s HealthNational Medical Research Center of Children’s HealthNational Medical Research Center of Children’s HealthNational Medical Research Center of Children’s HealthBackground. Excessive colonization of the skin by various bacteria and fungi can be noted in patients with atopic dermatitis (AD), and the prevalence of secondary infection complications 30–48%. Several studies have shown that Staphylococcus aureus colonization is 60–100% in patients with AD compared to 5–30% in healthy persons from the control group. Moreover, the incidence of methicillinresistant Staphylococcus aureus (MRSA) isolates is up to 10–30% in skin cultures at AD, according to experts. Therapy of AD complicated by secondary infection is one of the crucial challenges of modern dermatology. Mupirocin can be considered as one of the most effective topical antibiotic among others used for etiotropic therapy of infectious complications in AD patients, and it has been confirmed by numerous clinical studies.Conclusion. Staphylococcus aureus is the most common trigger of AD aggravation. MRSA in AD complicated by secondary infection is difficult to manage as it becomes resistant to many types of antibiotics; however, it shows persistent sensitivity to mupirocin. Mupirocin-based (2%) external agent is the most effective, safe, and preferred therapy variant for AD complicated by secondary infection in pediatrics.https://vsp.spr-journal.ru/jour/article/view/3301atopic dermatitischildrenstaphylococcus aureusmethicillin-resistant strainsmupirocin |
| spellingShingle | Nikolay N. Murashkin Alexander I. Materikin Roman V. Epishev Maria A. Leonova Leonid A. Opryatin Roman A. Ivanov Alena A. Savelova Features of Staphylococcus Aureus Antibiotic Sensitivity in Children with Atopic Dermatitis Вопросы современной педиатрии atopic dermatitis children staphylococcus aureus methicillin-resistant strains mupirocin |
| title | Features of Staphylococcus Aureus Antibiotic Sensitivity in Children with Atopic Dermatitis |
| title_full | Features of Staphylococcus Aureus Antibiotic Sensitivity in Children with Atopic Dermatitis |
| title_fullStr | Features of Staphylococcus Aureus Antibiotic Sensitivity in Children with Atopic Dermatitis |
| title_full_unstemmed | Features of Staphylococcus Aureus Antibiotic Sensitivity in Children with Atopic Dermatitis |
| title_short | Features of Staphylococcus Aureus Antibiotic Sensitivity in Children with Atopic Dermatitis |
| title_sort | features of staphylococcus aureus antibiotic sensitivity in children with atopic dermatitis |
| topic | atopic dermatitis children staphylococcus aureus methicillin-resistant strains mupirocin |
| url | https://vsp.spr-journal.ru/jour/article/view/3301 |
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