Effectiveness and safety of the ACE inhibitor and diuretic combination in postmenopausal women with arterial hypertension
Aim. To assess effectiveness, tolerability, and safety of combined antihypertensive therapy (AHT) with an ACE inhibitor (perindopril) and thiazide-like diuretic (indapamide) in postmenopausal women with arterial hypertension (AH). Material and methods. This open, one-centre study included 43 postmen...
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| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2011-06-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1804 |
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| author | G. G. Semenkova E. E. Matvienko |
| author_facet | G. G. Semenkova E. E. Matvienko |
| author_sort | G. G. Semenkova |
| collection | DOAJ |
| description | Aim. To assess effectiveness, tolerability, and safety of combined antihypertensive therapy (AHT) with an ACE inhibitor (perindopril) and thiazide-like diuretic (indapamide) in postmenopausal women with arterial hypertension (AH). Material and methods. This open, one-centre study included 43 postmenopausal women with AH. For 3 months, the patients in the main group (MG; n=22) received indapamide MR (modified release) (1,5 mg/d) and perindopril. The comparison group (CG; n=21) was administered non-MR indapamide (2,5 mg/d) and perindopril. The dynamics of office blood pressure (BP) levels, 24-hour BP monitoring parameters, laboratory parameters, quality of life (QoL), as well as therapy safety and tolerability, was assessed. Results. In both groups, the treatment was clinically effective, safe, and QoL-improving. Target BP levels were achieved in the majority of the patients: 85,3 % and 72,4 % in the MG and CG, respectively. The combination therapy including indapamide MR provided greater improvement of circadian BP rhythm, larger reduction in both morning BP surge and increased BP variability, as well as target BP achievement in higher proportion of the patients. Conclusion. In postmenopausal women with AH, combined therapy with perindopril and indapamide MR provided more benefits, compared to the treatment with perindopril and non-MR indapamide. |
| format | Article |
| id | doaj-art-7ff7c4eaec8245a1ab986b3ded285ba3 |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2011-06-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-7ff7c4eaec8245a1ab986b3ded285ba32025-08-20T03:43:29Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252011-06-01103353910.15829/1728-8800-2011-3-35-391519Effectiveness and safety of the ACE inhibitor and diuretic combination in postmenopausal women with arterial hypertensionG. G. Semenkova0E. E. Matvienko1N.N. Burdenko Voronezh State Medical AcademyVoronezh Region Clinical Hospital No. 2Aim. To assess effectiveness, tolerability, and safety of combined antihypertensive therapy (AHT) with an ACE inhibitor (perindopril) and thiazide-like diuretic (indapamide) in postmenopausal women with arterial hypertension (AH). Material and methods. This open, one-centre study included 43 postmenopausal women with AH. For 3 months, the patients in the main group (MG; n=22) received indapamide MR (modified release) (1,5 mg/d) and perindopril. The comparison group (CG; n=21) was administered non-MR indapamide (2,5 mg/d) and perindopril. The dynamics of office blood pressure (BP) levels, 24-hour BP monitoring parameters, laboratory parameters, quality of life (QoL), as well as therapy safety and tolerability, was assessed. Results. In both groups, the treatment was clinically effective, safe, and QoL-improving. Target BP levels were achieved in the majority of the patients: 85,3 % and 72,4 % in the MG and CG, respectively. The combination therapy including indapamide MR provided greater improvement of circadian BP rhythm, larger reduction in both morning BP surge and increased BP variability, as well as target BP achievement in higher proportion of the patients. Conclusion. In postmenopausal women with AH, combined therapy with perindopril and indapamide MR provided more benefits, compared to the treatment with perindopril and non-MR indapamide.https://cardiovascular.elpub.ru/jour/article/view/1804arterial hypertensionpostmenopauseperindoprilindapamide |
| spellingShingle | G. G. Semenkova E. E. Matvienko Effectiveness and safety of the ACE inhibitor and diuretic combination in postmenopausal women with arterial hypertension Кардиоваскулярная терапия и профилактика arterial hypertension postmenopause perindopril indapamide |
| title | Effectiveness and safety of the ACE inhibitor and diuretic combination in postmenopausal women with arterial hypertension |
| title_full | Effectiveness and safety of the ACE inhibitor and diuretic combination in postmenopausal women with arterial hypertension |
| title_fullStr | Effectiveness and safety of the ACE inhibitor and diuretic combination in postmenopausal women with arterial hypertension |
| title_full_unstemmed | Effectiveness and safety of the ACE inhibitor and diuretic combination in postmenopausal women with arterial hypertension |
| title_short | Effectiveness and safety of the ACE inhibitor and diuretic combination in postmenopausal women with arterial hypertension |
| title_sort | effectiveness and safety of the ace inhibitor and diuretic combination in postmenopausal women with arterial hypertension |
| topic | arterial hypertension postmenopause perindopril indapamide |
| url | https://cardiovascular.elpub.ru/jour/article/view/1804 |
| work_keys_str_mv | AT ggsemenkova effectivenessandsafetyoftheaceinhibitoranddiureticcombinationinpostmenopausalwomenwitharterialhypertension AT eematvienko effectivenessandsafetyoftheaceinhibitoranddiureticcombinationinpostmenopausalwomenwitharterialhypertension |