Genetic polymorphisms as predictors of methotrexate toxicity: literature review

Genetic polymorphisms as predictors of methotrexate toxicity: literature review

Background. A significant advancement in the treatment of high-grade aggressive non-Hodgkin’s lymphomas and acute lymphoblastic leukemia is the inclusion of high-dose (1000–5000 mg/m2) methotrexate in the treatment protocol. This approach has significantly increased the long-term survival rate, but...

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Bibliographic Details
Main Authors: G. A. Radzhabova, T. T. Valiev, Yu. E. Ryabukhina, M. I. Savelyeva, Sh. P. Abdullaev, O. D. Gurieva, P. A. Zeynalova
Format: Article
Language:Russian
Published: ABV-press 2024-04-01
Series:Онкогематология
Subjects:
genetic polymorphisms
high-dose methotrexate
methotrexate toxicity
methotrexate pharmacogenetics
Online Access:https://oncohematology.abvpress.ru/ongm/article/view/921
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