Identification of mitophagy-related genes in patients with acute myocardial infarction
Abstract Mitophagy is involved in acute myocardial infarction (AMI) process. However, the role of mitophagy-related genes (MRGs) in the AMI process is not well illustrated. We identified MRGs involved in AMI by bioinformatics analysis. The external datasets were employed for the validation of the MR...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | Hereditas |
| Online Access: | https://doi.org/10.1186/s41065-025-00424-5 |
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| author | Ju-Ying Li Hong-Kui Chen Yi-Hao Huang Yu-Peng Zhi Yue-E Li Kai-Yang Lin Chun Chen Yan-Song Guo |
| author_facet | Ju-Ying Li Hong-Kui Chen Yi-Hao Huang Yu-Peng Zhi Yue-E Li Kai-Yang Lin Chun Chen Yan-Song Guo |
| author_sort | Ju-Ying Li |
| collection | DOAJ |
| description | Abstract Mitophagy is involved in acute myocardial infarction (AMI) process. However, the role of mitophagy-related genes (MRGs) in the AMI process is not well illustrated. We identified MRGs involved in AMI by bioinformatics analysis. The external datasets were employed for the validation of the MRGs, alongside the execution of cellular and animal experiments. Forty-five MRGs were detected, and machine learning identified the top four hub genes, namely ALDH2, ACSL1, IL1B, and GABARAPL1. Additionally, an external validation set was used to screen for three diagnostic markers (ACSL1, IL1B, and GABARAPL1) among these hub genes. Immune infiltration analysis revealed changes in the immune microenvironment among patients with AMI. Finally, the significant upregulation of ACSL1, IL1B, and GABARAPL1 in both cellular and animal models was confirmed. The occurrence of mitophagy was observed in the cell model through transmission electron microscopy (TEM). Our study demonstrated that ACSL1, IL1B, and GABARAPL1 possess potential biomarkers for AMI. |
| format | Article |
| id | doaj-art-7ff28bd6745a49e98698a99b6a1537c3 |
| institution | DOAJ |
| issn | 1601-5223 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Hereditas |
| spelling | doaj-art-7ff28bd6745a49e98698a99b6a1537c32025-08-20T03:15:12ZengBMCHereditas1601-52232025-04-01162111410.1186/s41065-025-00424-5Identification of mitophagy-related genes in patients with acute myocardial infarctionJu-Ying Li0Hong-Kui Chen1Yi-Hao Huang2Yu-Peng Zhi3Yue-E Li4Kai-Yang Lin5Chun Chen6Yan-Song Guo7The First People’s Hospital of YibinShenli Clincal Medical College of Fujian Medical UniversitySchool of Pharmacy, Fujian Medical UniversitySchool of Pharmacy, Fujian Medical UniversitySchool of Pharmacy, Fujian Medical UniversityShenli Clincal Medical College of Fujian Medical UniversitySchool of Pharmacy, Fujian Medical UniversityShenli Clincal Medical College of Fujian Medical UniversityAbstract Mitophagy is involved in acute myocardial infarction (AMI) process. However, the role of mitophagy-related genes (MRGs) in the AMI process is not well illustrated. We identified MRGs involved in AMI by bioinformatics analysis. The external datasets were employed for the validation of the MRGs, alongside the execution of cellular and animal experiments. Forty-five MRGs were detected, and machine learning identified the top four hub genes, namely ALDH2, ACSL1, IL1B, and GABARAPL1. Additionally, an external validation set was used to screen for three diagnostic markers (ACSL1, IL1B, and GABARAPL1) among these hub genes. Immune infiltration analysis revealed changes in the immune microenvironment among patients with AMI. Finally, the significant upregulation of ACSL1, IL1B, and GABARAPL1 in both cellular and animal models was confirmed. The occurrence of mitophagy was observed in the cell model through transmission electron microscopy (TEM). Our study demonstrated that ACSL1, IL1B, and GABARAPL1 possess potential biomarkers for AMI.https://doi.org/10.1186/s41065-025-00424-5 |
| spellingShingle | Ju-Ying Li Hong-Kui Chen Yi-Hao Huang Yu-Peng Zhi Yue-E Li Kai-Yang Lin Chun Chen Yan-Song Guo Identification of mitophagy-related genes in patients with acute myocardial infarction Hereditas |
| title | Identification of mitophagy-related genes in patients with acute myocardial infarction |
| title_full | Identification of mitophagy-related genes in patients with acute myocardial infarction |
| title_fullStr | Identification of mitophagy-related genes in patients with acute myocardial infarction |
| title_full_unstemmed | Identification of mitophagy-related genes in patients with acute myocardial infarction |
| title_short | Identification of mitophagy-related genes in patients with acute myocardial infarction |
| title_sort | identification of mitophagy related genes in patients with acute myocardial infarction |
| url | https://doi.org/10.1186/s41065-025-00424-5 |
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