Persistent effect of tocilizumab in refractory Takayasu’s arteritis (clinical observation)
Study of the interleukin 6 (IL-6) role in chronic autoimmune inflammation has led to the development of innovative treatments for various autoimmune inflammatory rheumatic diseases, including Takayasu’s arteritis (TAK). Given the important role of IL-6 in the pathogenesis of TAK and its association...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2022-05-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/3158 |
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| author | G. M. Koilubaeva A. Sh. Sarybaev A. M. Bolotbekova T. V. Dubinina E. L. Nasonov F. S. Dzhuzenova M. A. Chukubaev Z. E. Turdukulov K. A. Dzhailobaeva |
| author_facet | G. M. Koilubaeva A. Sh. Sarybaev A. M. Bolotbekova T. V. Dubinina E. L. Nasonov F. S. Dzhuzenova M. A. Chukubaev Z. E. Turdukulov K. A. Dzhailobaeva |
| author_sort | G. M. Koilubaeva |
| collection | DOAJ |
| description | Study of the interleukin 6 (IL-6) role in chronic autoimmune inflammation has led to the development of innovative treatments for various autoimmune inflammatory rheumatic diseases, including Takayasu’s arteritis (TAK). Given the important role of IL-6 in the pathogenesis of TAK and its association with high clinical and laboratory activity of the disease, tocilizumab (TCZ) is recommended as a second-line drug if both glucocorticoids and basic antiinflammatory drugs are inefficient, and previous therapy with tumor necrosis factor-α (alpha) inhibitors. The article presents our own observation of the successful use of TCZ in a patient with refractory TAK. |
| format | Article |
| id | doaj-art-7fef65daed3d46b290496fce4693569b |
| institution | Kabale University |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2022-05-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-7fef65daed3d46b290496fce4693569b2025-08-20T03:37:53ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922022-05-0160224224810.47360/1995-4484-2022-242-2482802Persistent effect of tocilizumab in refractory Takayasu’s arteritis (clinical observation)G. M. Koilubaeva0A. Sh. Sarybaev1A. M. Bolotbekova2T. V. Dubinina3E. L. Nasonov4F. S. Dzhuzenova5M. A. Chukubaev6Z. E. Turdukulov7K. A. Dzhailobaeva8National Center for Cardiology and Therapy named after Academician Mirsaid Mirrakhimov under the Ministry of Health of the Kyrgyz RepublicNational Center for Cardiology and Therapy named after Academician Mirsaid Mirrakhimov under the Ministry of Health of the Kyrgyz RepublicNational Center for Cardiology and Therapy named after Academician Mirsaid Mirrakhimov under the Ministry of Health of the Kyrgyz RepublicV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyNational Center for Cardiology and Therapy named after Academician Mirsaid Mirrakhimov under the Ministry of Health of the Kyrgyz RepublicNational Center for Cardiology and Therapy named after Academician Mirsaid Mirrakhimov under the Ministry of Health of the Kyrgyz RepublicNational Center for Cardiology and Therapy named after Academician Mirsaid Mirrakhimov under the Ministry of Health of the Kyrgyz RepublicB.N. Yeltsin Kyrgyz-Russian Slavic UniversityStudy of the interleukin 6 (IL-6) role in chronic autoimmune inflammation has led to the development of innovative treatments for various autoimmune inflammatory rheumatic diseases, including Takayasu’s arteritis (TAK). Given the important role of IL-6 in the pathogenesis of TAK and its association with high clinical and laboratory activity of the disease, tocilizumab (TCZ) is recommended as a second-line drug if both glucocorticoids and basic antiinflammatory drugs are inefficient, and previous therapy with tumor necrosis factor-α (alpha) inhibitors. The article presents our own observation of the successful use of TCZ in a patient with refractory TAK.https://rsp.mediar-press.net/rsp/article/view/3158takayasu’s arteritisinterleukin 6inflammationtocilizumabrefractorinessactivitystenosis |
| spellingShingle | G. M. Koilubaeva A. Sh. Sarybaev A. M. Bolotbekova T. V. Dubinina E. L. Nasonov F. S. Dzhuzenova M. A. Chukubaev Z. E. Turdukulov K. A. Dzhailobaeva Persistent effect of tocilizumab in refractory Takayasu’s arteritis (clinical observation) Научно-практическая ревматология takayasu’s arteritis interleukin 6 inflammation tocilizumab refractoriness activity stenosis |
| title | Persistent effect of tocilizumab in refractory Takayasu’s arteritis (clinical observation) |
| title_full | Persistent effect of tocilizumab in refractory Takayasu’s arteritis (clinical observation) |
| title_fullStr | Persistent effect of tocilizumab in refractory Takayasu’s arteritis (clinical observation) |
| title_full_unstemmed | Persistent effect of tocilizumab in refractory Takayasu’s arteritis (clinical observation) |
| title_short | Persistent effect of tocilizumab in refractory Takayasu’s arteritis (clinical observation) |
| title_sort | persistent effect of tocilizumab in refractory takayasu s arteritis clinical observation |
| topic | takayasu’s arteritis interleukin 6 inflammation tocilizumab refractoriness activity stenosis |
| url | https://rsp.mediar-press.net/rsp/article/view/3158 |
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