Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy
Abstract Cancer remains a global health challenge necessitating innovative therapies. We introduce a strategy to disrupt cancer cell redox balance using gold nanoparticles (Au NPs) as electron sinks combined with electroactive membranes. Utilizing Shewanella oneidensis MR-1 membrane proteins, we dev...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-58636-2 |
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| author | Ying-Chi Chen Li-Chan Chang Yan-Ling Liu Ming-Che Chang Yin-Fen Liu Po-Ya Chang Divinah Manoharan Wen-Jyun Wang Jia-Sin Chen Hsueh-Chun Wang Wen-Tai Chiu Wei-Peng Li Hwo-Shuenn Sheu Wen-Pin Su Chen-Sheng Yeh |
| author_facet | Ying-Chi Chen Li-Chan Chang Yan-Ling Liu Ming-Che Chang Yin-Fen Liu Po-Ya Chang Divinah Manoharan Wen-Jyun Wang Jia-Sin Chen Hsueh-Chun Wang Wen-Tai Chiu Wei-Peng Li Hwo-Shuenn Sheu Wen-Pin Su Chen-Sheng Yeh |
| author_sort | Ying-Chi Chen |
| collection | DOAJ |
| description | Abstract Cancer remains a global health challenge necessitating innovative therapies. We introduce a strategy to disrupt cancer cell redox balance using gold nanoparticles (Au NPs) as electron sinks combined with electroactive membranes. Utilizing Shewanella oneidensis MR-1 membrane proteins, we develop liposomes enriched with c-type cytochromes. These, coupled with Au NPs, facilitate autonomous electron transfer from cancer cells, disrupting redox processes and inducing cell death. Effective across various cancer types, larger Au NPs show enhanced efficacy, especially under hypoxic conditions. Oxidative stress from Au@MIL (MIL: membrane-integrated liposome) treatments, including mitochondrial and endoplasmic reticulum lipid oxidation and mitochondrial membrane potential changes, triggers apoptosis, bypassing iron-mediated pathways. Surface plasmon band and X-ray absorption near-edge structure (XANES) analyses confirm electron transfer. A SiO2 insulator coating on Au NPs blocks this transfer, suppressing cancer cell damage. This approach highlights the potential of modulated electron transfer pathways in targeted cancer therapy, offering refined and effective treatments. |
| format | Article |
| id | doaj-art-7fedcabcd9e84f70bf2df7135b16edb7 |
| institution | DOAJ |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-7fedcabcd9e84f70bf2df7135b16edb72025-08-20T03:07:43ZengNature PortfolioNature Communications2041-17232025-04-0116111710.1038/s41467-025-58636-2Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapyYing-Chi Chen0Li-Chan Chang1Yan-Ling Liu2Ming-Che Chang3Yin-Fen Liu4Po-Ya Chang5Divinah Manoharan6Wen-Jyun Wang7Jia-Sin Chen8Hsueh-Chun Wang9Wen-Tai Chiu10Wei-Peng Li11Hwo-Shuenn Sheu12Wen-Pin Su13Chen-Sheng Yeh14Department of Chemistry, National Cheng Kung UniversityInstitute of Clinical Medicine, College of Medicine, National Cheng Kung UniversityDepartment of Chemistry, National Cheng Kung UniversityDepartment of Chemistry, National Cheng Kung UniversityInstitute of Clinical Medicine, College of Medicine, National Cheng Kung UniversityNational Synchrotron Radiation Research CenterDepartment of Chemistry, National Cheng Kung UniversityDepartment of Medicinal and Applied Chemistry, Kaohsiung Medical UniversityDepartment of Medicinal and Applied Chemistry, Kaohsiung Medical UniversityDepartment of Biomedical Engineering, National Cheng Kung UniversityDepartment of Biomedical Engineering, National Cheng Kung UniversityDepartment of Medicinal and Applied Chemistry, Kaohsiung Medical UniversityNational Synchrotron Radiation Research CenterInstitute of Clinical Medicine, College of Medicine, National Cheng Kung UniversityDepartment of Chemistry, National Cheng Kung UniversityAbstract Cancer remains a global health challenge necessitating innovative therapies. We introduce a strategy to disrupt cancer cell redox balance using gold nanoparticles (Au NPs) as electron sinks combined with electroactive membranes. Utilizing Shewanella oneidensis MR-1 membrane proteins, we develop liposomes enriched with c-type cytochromes. These, coupled with Au NPs, facilitate autonomous electron transfer from cancer cells, disrupting redox processes and inducing cell death. Effective across various cancer types, larger Au NPs show enhanced efficacy, especially under hypoxic conditions. Oxidative stress from Au@MIL (MIL: membrane-integrated liposome) treatments, including mitochondrial and endoplasmic reticulum lipid oxidation and mitochondrial membrane potential changes, triggers apoptosis, bypassing iron-mediated pathways. Surface plasmon band and X-ray absorption near-edge structure (XANES) analyses confirm electron transfer. A SiO2 insulator coating on Au NPs blocks this transfer, suppressing cancer cell damage. This approach highlights the potential of modulated electron transfer pathways in targeted cancer therapy, offering refined and effective treatments.https://doi.org/10.1038/s41467-025-58636-2 |
| spellingShingle | Ying-Chi Chen Li-Chan Chang Yan-Ling Liu Ming-Che Chang Yin-Fen Liu Po-Ya Chang Divinah Manoharan Wen-Jyun Wang Jia-Sin Chen Hsueh-Chun Wang Wen-Tai Chiu Wei-Peng Li Hwo-Shuenn Sheu Wen-Pin Su Chen-Sheng Yeh Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy Nature Communications |
| title | Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy |
| title_full | Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy |
| title_fullStr | Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy |
| title_full_unstemmed | Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy |
| title_short | Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy |
| title_sort | redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy |
| url | https://doi.org/10.1038/s41467-025-58636-2 |
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