A case of intravascular large B-cell lymphoma complicated by hypercalcaemia
Introduction: Hypercalcaemia in intravascular large B-cell lymphoma (IVLBCL) is extremely rare, occurring more often in other non-Hodgkin’s lymphomas (NHL). Case description: A 68-year-old man was admitted with a fever of unknown origin, mild disturbance of consciousness and respiratory failure. Lab...
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| Language: | English |
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SMC MEDIA SRL
2025-04-01
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| Series: | European Journal of Case Reports in Internal Medicine |
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| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/5406 |
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| author | Masahiro Yabe Takashi Abe Saori Yamaga Seiga Ozaki Katsuhiro Tomiyama Hideki Hashidate |
| author_facet | Masahiro Yabe Takashi Abe Saori Yamaga Seiga Ozaki Katsuhiro Tomiyama Hideki Hashidate |
| author_sort | Masahiro Yabe |
| collection | DOAJ |
| description | Introduction: Hypercalcaemia in intravascular large B-cell lymphoma (IVLBCL) is extremely rare, occurring more often in other non-Hodgkin’s lymphomas (NHL).
Case description: A 68-year-old man was admitted with a fever of unknown origin, mild disturbance of consciousness and respiratory failure. Laboratory findings showed hypercalcaemia with elevated parathyroid hormone-related protein (PTHrP) and decreased intact parathyroid hormone and 1,25-dihydroxyvitamin D. The patient was diagnosed with IVLBCL via random skin biopsy. Chemotherapy resulted in complete remission and normalised PTHrP levels.
Conclusion: More than half of all cases of hypercalcaemia in NHL are not associated with PTHrP or 1,25-dihydroxyvitamin D, and the cause of the hypercalcaemia is unknown. However, PTHrP levels are elevated in most cases of IVLBCL with hypercalcaemia, which may present as humoral hypercalcaemia of malignancy. |
| format | Article |
| id | doaj-art-7fe3ecd152774d628f220e9b8263ca11 |
| institution | DOAJ |
| issn | 2284-2594 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj-art-7fe3ecd152774d628f220e9b8263ca112025-08-20T03:11:25ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942025-04-0110.12890/2025_0054064941A case of intravascular large B-cell lymphoma complicated by hypercalcaemiaMasahiro Yabe0Takashi Abe1Saori Yamaga2Seiga Ozaki3Katsuhiro Tomiyama4Hideki Hashidate5Department of General Internal Medicine, Niigata City General Hospital, Niigata, JapanDepartment of Hematology, Niigata City General Hospital, Niigata, JapanDepartment of General Internal Medicine, Niigata City General Hospital, Niigata, JapanDepartment of General Internal Medicine, Niigata City General Hospital, Niigata, JapanDepartment of Dermatology, Niigata City General Hospital, Niigata, JapanDepartment of Pathology, Niigata City General Hospital, Niigata, JapanIntroduction: Hypercalcaemia in intravascular large B-cell lymphoma (IVLBCL) is extremely rare, occurring more often in other non-Hodgkin’s lymphomas (NHL). Case description: A 68-year-old man was admitted with a fever of unknown origin, mild disturbance of consciousness and respiratory failure. Laboratory findings showed hypercalcaemia with elevated parathyroid hormone-related protein (PTHrP) and decreased intact parathyroid hormone and 1,25-dihydroxyvitamin D. The patient was diagnosed with IVLBCL via random skin biopsy. Chemotherapy resulted in complete remission and normalised PTHrP levels. Conclusion: More than half of all cases of hypercalcaemia in NHL are not associated with PTHrP or 1,25-dihydroxyvitamin D, and the cause of the hypercalcaemia is unknown. However, PTHrP levels are elevated in most cases of IVLBCL with hypercalcaemia, which may present as humoral hypercalcaemia of malignancy.https://www.ejcrim.com/index.php/EJCRIM/article/view/5406intravascular large b-cell lymphomahypercalcaemiaparathyroid hormone-related proteinhumoral hypercalcaemia of malignancy |
| spellingShingle | Masahiro Yabe Takashi Abe Saori Yamaga Seiga Ozaki Katsuhiro Tomiyama Hideki Hashidate A case of intravascular large B-cell lymphoma complicated by hypercalcaemia European Journal of Case Reports in Internal Medicine intravascular large b-cell lymphoma hypercalcaemia parathyroid hormone-related protein humoral hypercalcaemia of malignancy |
| title | A case of intravascular large B-cell lymphoma complicated by hypercalcaemia |
| title_full | A case of intravascular large B-cell lymphoma complicated by hypercalcaemia |
| title_fullStr | A case of intravascular large B-cell lymphoma complicated by hypercalcaemia |
| title_full_unstemmed | A case of intravascular large B-cell lymphoma complicated by hypercalcaemia |
| title_short | A case of intravascular large B-cell lymphoma complicated by hypercalcaemia |
| title_sort | case of intravascular large b cell lymphoma complicated by hypercalcaemia |
| topic | intravascular large b-cell lymphoma hypercalcaemia parathyroid hormone-related protein humoral hypercalcaemia of malignancy |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/5406 |
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