Obtaining, purification of antibodies (IgY) from hyperimmune egg yolk with activity against viral pathogens and formulation of some therapeutic products
In recent decades, avian antibody technology has become more popular in the medical field, successfully replacing the immunoglobulins obtained from mammals. Y antibodies (IgY) are extracted from the yolk of hyperimmune eggs harvested from hens (Gallus domesticus) immunized with different antigens an...
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| Format: | Article |
| Language: | English |
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Asociaţia Naţională a Fabricanţilor de Produse de Uz Veterinar
2019-05-01
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| Series: | Medicamentul Veterinar |
| Online Access: | http://www.veterinarypharmacon.com/docs/2037-2019_VD_13(1)_ART_6_ENG.pdf |
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| _version_ | 1850054303597723648 |
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| author | Teodora Supeanu Mariana Oporanu Lucica Sima Viorica Chiurciu Constantin Chiurciu1 |
| author_facet | Teodora Supeanu Mariana Oporanu Lucica Sima Viorica Chiurciu Constantin Chiurciu1 |
| author_sort | Teodora Supeanu |
| collection | DOAJ |
| description | In recent decades, avian antibody technology has become more popular in the medical field, successfully replacing the immunoglobulins obtained from mammals. Y antibodies (IgY) are extracted from the yolk of hyperimmune eggs harvested from hens (Gallus domesticus) immunized with different antigens and have an already proven applicability in various medical fields such as the manufacture of diagnostic kits and the development of passive antibody therapy protocols for various infectious diseases. It is well known that avian immunoglobulin therapy is effective in the prevention and treatment of bacterial diseases in humans and animals, especially with gastrointestinal localization. In the present study, the production of avian immunoglobulins with antiviral activity, their extraction, and purification, as well as the formulation of therapeutic products for administration to human patients exhibiting clinically symptomatic infections with rotavirus, Herpes simplex virus type 1, human papillomavirus or Varicella zoster virus. These are highly pathogenic viruses, leading to significant human morbidity and mortality, for which the therapeutic options are currently quite limited. |
| format | Article |
| id | doaj-art-7fe19b9615ef430992152d7e3aec5ac0 |
| institution | DOAJ |
| issn | 1843-9527 2069-2463 |
| language | English |
| publishDate | 2019-05-01 |
| publisher | Asociaţia Naţională a Fabricanţilor de Produse de Uz Veterinar |
| record_format | Article |
| series | Medicamentul Veterinar |
| spelling | doaj-art-7fe19b9615ef430992152d7e3aec5ac02025-08-20T02:52:19ZengAsociaţia Naţională a Fabricanţilor de Produse de Uz VeterinarMedicamentul Veterinar1843-95272069-24632019-05-011316975Obtaining, purification of antibodies (IgY) from hyperimmune egg yolk with activity against viral pathogens and formulation of some therapeutic productsTeodora Supeanu0Mariana Oporanu1 Lucica Sima2Viorica Chiurciu3Constantin Chiurciu14Romvac Company Bucharest, RORomvac Company Bucharest, RORomvac Company Bucharest, RORomvac Company Bucharest, RORomvac Company Bucharest, ROIn recent decades, avian antibody technology has become more popular in the medical field, successfully replacing the immunoglobulins obtained from mammals. Y antibodies (IgY) are extracted from the yolk of hyperimmune eggs harvested from hens (Gallus domesticus) immunized with different antigens and have an already proven applicability in various medical fields such as the manufacture of diagnostic kits and the development of passive antibody therapy protocols for various infectious diseases. It is well known that avian immunoglobulin therapy is effective in the prevention and treatment of bacterial diseases in humans and animals, especially with gastrointestinal localization. In the present study, the production of avian immunoglobulins with antiviral activity, their extraction, and purification, as well as the formulation of therapeutic products for administration to human patients exhibiting clinically symptomatic infections with rotavirus, Herpes simplex virus type 1, human papillomavirus or Varicella zoster virus. These are highly pathogenic viruses, leading to significant human morbidity and mortality, for which the therapeutic options are currently quite limited.http://www.veterinarypharmacon.com/docs/2037-2019_VD_13(1)_ART_6_ENG.pdf |
| spellingShingle | Teodora Supeanu Mariana Oporanu Lucica Sima Viorica Chiurciu Constantin Chiurciu1 Obtaining, purification of antibodies (IgY) from hyperimmune egg yolk with activity against viral pathogens and formulation of some therapeutic products Medicamentul Veterinar |
| title | Obtaining, purification of antibodies (IgY) from hyperimmune egg yolk with activity against viral pathogens and formulation of some therapeutic products |
| title_full | Obtaining, purification of antibodies (IgY) from hyperimmune egg yolk with activity against viral pathogens and formulation of some therapeutic products |
| title_fullStr | Obtaining, purification of antibodies (IgY) from hyperimmune egg yolk with activity against viral pathogens and formulation of some therapeutic products |
| title_full_unstemmed | Obtaining, purification of antibodies (IgY) from hyperimmune egg yolk with activity against viral pathogens and formulation of some therapeutic products |
| title_short | Obtaining, purification of antibodies (IgY) from hyperimmune egg yolk with activity against viral pathogens and formulation of some therapeutic products |
| title_sort | obtaining purification of antibodies igy from hyperimmune egg yolk with activity against viral pathogens and formulation of some therapeutic products |
| url | http://www.veterinarypharmacon.com/docs/2037-2019_VD_13(1)_ART_6_ENG.pdf |
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