A Clinical Analysis of Risk Factors for Interstitial Lung Disease in Patients with Idiopathic Inflammatory Myopathy
Interstitial lung disease (ILD) is a common and severe complication of idiopathic inflammatory myopathies (IIM). The aim of our study was to identify risk factors for ILD by evaluating both clinical and biochemical features in IIM patients with or without ILD. From January 2008 to December 2011, med...
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| Format: | Article |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/648570 |
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| author | Xiaomin Cen Chuan Zuo Min Yang Geng Yin Qibing Xie |
| author_facet | Xiaomin Cen Chuan Zuo Min Yang Geng Yin Qibing Xie |
| author_sort | Xiaomin Cen |
| collection | DOAJ |
| description | Interstitial lung disease (ILD) is a common and severe complication of idiopathic inflammatory myopathies (IIM). The aim of our study was to identify risk factors for ILD by evaluating both clinical and biochemical features in IIM patients with or without ILD. From January 2008 to December 2011, medical records of 134 IIM patients in our rheumatology unit were reviewed. The patients were divided into ILD group (83 patients) and non-ILD group (51 patients). The clinical features and laboratory findings were compared. The univariable analyses indicated that arthritis/arthralgia (54.2% versus 17.6%, P<0.05), Mechanic’s hand (16.9% versus 2.0%, P<0.05), Raynaud’s phenomenon (36.1% versus 2.0%, P<0.05), heliotrope rash (44.6% versus 19.6%, P<0.05), fever (43.4% versus 21.6%, P<0.05), elevated ESR (60.2% versus 35.3%, P<0.05), elevated CRP (55.4% versus 31.4%, P<0.05), or anti-Jo-1 antibody (20.5% versus 5.9%, P<0.05) were risk factors for developing ILD in IIM. Multivariable unconditional logistic regression analysis that showed arthritis/arthralgia (OR 7.1, 95% CI 2.8–18.1), Raynaud’s phenomenon (OR 29.1, 95% CI 3.6–233.7), and amyopathic dermatomyositis (ADM) (OR 20.2, 95% CI 2.4–171.2) were the independent risk factors for developing ILD in IIM. |
| format | Article |
| id | doaj-art-7fdbe1ed02f8431b84cb39da2c0f3a88 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-7fdbe1ed02f8431b84cb39da2c0f3a882025-08-20T03:35:20ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/648570648570A Clinical Analysis of Risk Factors for Interstitial Lung Disease in Patients with Idiopathic Inflammatory MyopathyXiaomin Cen0Chuan Zuo1Min Yang2Geng Yin3Qibing Xie4Department of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, ChinaInterstitial lung disease (ILD) is a common and severe complication of idiopathic inflammatory myopathies (IIM). The aim of our study was to identify risk factors for ILD by evaluating both clinical and biochemical features in IIM patients with or without ILD. From January 2008 to December 2011, medical records of 134 IIM patients in our rheumatology unit were reviewed. The patients were divided into ILD group (83 patients) and non-ILD group (51 patients). The clinical features and laboratory findings were compared. The univariable analyses indicated that arthritis/arthralgia (54.2% versus 17.6%, P<0.05), Mechanic’s hand (16.9% versus 2.0%, P<0.05), Raynaud’s phenomenon (36.1% versus 2.0%, P<0.05), heliotrope rash (44.6% versus 19.6%, P<0.05), fever (43.4% versus 21.6%, P<0.05), elevated ESR (60.2% versus 35.3%, P<0.05), elevated CRP (55.4% versus 31.4%, P<0.05), or anti-Jo-1 antibody (20.5% versus 5.9%, P<0.05) were risk factors for developing ILD in IIM. Multivariable unconditional logistic regression analysis that showed arthritis/arthralgia (OR 7.1, 95% CI 2.8–18.1), Raynaud’s phenomenon (OR 29.1, 95% CI 3.6–233.7), and amyopathic dermatomyositis (ADM) (OR 20.2, 95% CI 2.4–171.2) were the independent risk factors for developing ILD in IIM.http://dx.doi.org/10.1155/2013/648570 |
| spellingShingle | Xiaomin Cen Chuan Zuo Min Yang Geng Yin Qibing Xie A Clinical Analysis of Risk Factors for Interstitial Lung Disease in Patients with Idiopathic Inflammatory Myopathy Clinical and Developmental Immunology |
| title | A Clinical Analysis of Risk Factors for Interstitial Lung Disease in Patients with Idiopathic Inflammatory Myopathy |
| title_full | A Clinical Analysis of Risk Factors for Interstitial Lung Disease in Patients with Idiopathic Inflammatory Myopathy |
| title_fullStr | A Clinical Analysis of Risk Factors for Interstitial Lung Disease in Patients with Idiopathic Inflammatory Myopathy |
| title_full_unstemmed | A Clinical Analysis of Risk Factors for Interstitial Lung Disease in Patients with Idiopathic Inflammatory Myopathy |
| title_short | A Clinical Analysis of Risk Factors for Interstitial Lung Disease in Patients with Idiopathic Inflammatory Myopathy |
| title_sort | clinical analysis of risk factors for interstitial lung disease in patients with idiopathic inflammatory myopathy |
| url | http://dx.doi.org/10.1155/2013/648570 |
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