Dendritic Spines and Development: Towards a Unifying Model of Spinogenesis—A Present Day Review of Cajal's Histological Slides and Drawings
Dendritic spines receive the majority of excitatory connections in the central nervous system, and, thus, they are key structures in the regulation of neural activity. Hence, the cellular and molecular mechanisms underlying their generation and plasticity, both during development and in adulthood, a...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2010/769207 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849409852852404224 |
|---|---|
| author | Pablo García-López Virginia García-Marín Miguel Freire |
| author_facet | Pablo García-López Virginia García-Marín Miguel Freire |
| author_sort | Pablo García-López |
| collection | DOAJ |
| description | Dendritic spines receive the majority of excitatory connections in the central nervous system, and, thus, they are key structures in the regulation of neural activity. Hence, the cellular and molecular mechanisms underlying their generation and plasticity, both during development and in adulthood, are a matter of fundamental and practical interest. Indeed, a better understanding of these mechanisms should provide clues to the development of novel clinical therapies. Here, we present original results obtained from high-quality images of Cajal's histological preparations, stored at the Cajal Museum (Instituto Cajal, CSIC), obtained using extended focus imaging, three-dimensional reconstruction, and rendering. Based on the data available in the literature regarding the formation of dendritic spines during development and our results, we propose a unifying model for dendritic spine development. |
| format | Article |
| id | doaj-art-7fd93716dee4494ba1168dfffc111c0b |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-7fd93716dee4494ba1168dfffc111c0b2025-08-20T03:35:20ZengWileyNeural Plasticity2090-59041687-54432010-01-01201010.1155/2010/769207769207Dendritic Spines and Development: Towards a Unifying Model of Spinogenesis—A Present Day Review of Cajal's Histological Slides and DrawingsPablo García-López0Virginia García-Marín1Miguel Freire2Department of Molecular, Cellular and Developmental Neurobiology, Instituto Cajal, CSIC, Avenida Doctor Arce 37, 28002 Madrid, SpainDepartment of Molecular, Cellular and Developmental Neurobiology, Instituto Cajal, CSIC, Avenida Doctor Arce 37, 28002 Madrid, SpainDepartment of Molecular, Cellular and Developmental Neurobiology, Instituto Cajal, CSIC, Avenida Doctor Arce 37, 28002 Madrid, SpainDendritic spines receive the majority of excitatory connections in the central nervous system, and, thus, they are key structures in the regulation of neural activity. Hence, the cellular and molecular mechanisms underlying their generation and plasticity, both during development and in adulthood, are a matter of fundamental and practical interest. Indeed, a better understanding of these mechanisms should provide clues to the development of novel clinical therapies. Here, we present original results obtained from high-quality images of Cajal's histological preparations, stored at the Cajal Museum (Instituto Cajal, CSIC), obtained using extended focus imaging, three-dimensional reconstruction, and rendering. Based on the data available in the literature regarding the formation of dendritic spines during development and our results, we propose a unifying model for dendritic spine development.http://dx.doi.org/10.1155/2010/769207 |
| spellingShingle | Pablo García-López Virginia García-Marín Miguel Freire Dendritic Spines and Development: Towards a Unifying Model of Spinogenesis—A Present Day Review of Cajal's Histological Slides and Drawings Neural Plasticity |
| title | Dendritic Spines and Development: Towards a Unifying Model of Spinogenesis—A Present Day Review of Cajal's Histological Slides and Drawings |
| title_full | Dendritic Spines and Development: Towards a Unifying Model of Spinogenesis—A Present Day Review of Cajal's Histological Slides and Drawings |
| title_fullStr | Dendritic Spines and Development: Towards a Unifying Model of Spinogenesis—A Present Day Review of Cajal's Histological Slides and Drawings |
| title_full_unstemmed | Dendritic Spines and Development: Towards a Unifying Model of Spinogenesis—A Present Day Review of Cajal's Histological Slides and Drawings |
| title_short | Dendritic Spines and Development: Towards a Unifying Model of Spinogenesis—A Present Day Review of Cajal's Histological Slides and Drawings |
| title_sort | dendritic spines and development towards a unifying model of spinogenesis a present day review of cajal s histological slides and drawings |
| url | http://dx.doi.org/10.1155/2010/769207 |
| work_keys_str_mv | AT pablogarcialopez dendriticspinesanddevelopmenttowardsaunifyingmodelofspinogenesisapresentdayreviewofcajalshistologicalslidesanddrawings AT virginiagarciamarin dendriticspinesanddevelopmenttowardsaunifyingmodelofspinogenesisapresentdayreviewofcajalshistologicalslidesanddrawings AT miguelfreire dendriticspinesanddevelopmenttowardsaunifyingmodelofspinogenesisapresentdayreviewofcajalshistologicalslidesanddrawings |