Evaluation of Potential Factors Contributing to Microbiological Treatment Failure in Streptococcus Pyogenes Pharyngitis
BACKGROUND: A cohort study of children with pharyngitis aged two to 16 years was conducted to assess the role of microbial and host factors in group A beta-hemolytic streptococcus (GABHS) microbiological treatment failure. METHODS: GABHS-infected children had pharyngeal swabs repeated tw...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2001-01-01
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| Series: | Canadian Journal of Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2001/297304 |
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| _version_ | 1849409852383690752 |
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| author | Susan M Kuhn Jutta Preiksaitis Gregory J Tyrrell Taj Jadavji Deirdre Church H Dele Davies |
| author_facet | Susan M Kuhn Jutta Preiksaitis Gregory J Tyrrell Taj Jadavji Deirdre Church H Dele Davies |
| author_sort | Susan M Kuhn |
| collection | DOAJ |
| description | BACKGROUND: A cohort study of children with pharyngitis aged two to 16 years was conducted to assess the role of microbial and host factors in group A beta-hemolytic streptococcus (GABHS) microbiological treatment failure. METHODS: GABHS-infected children had pharyngeal swabs repeated two to five days after completing a 10-day course of penicillin V. M and T typing, and pulsed field gel electrophoresis were performed on the isolates, and the isolates were evaluated for tolerance. Patient characteristics and clinical features were noted and nasopharyngeal swabs for respiratory viruses were taken at enrolment. RESULTS AND CONCLUSIONS: Of 286 patients enrolled, 248 (87%) could be evaluated. GABHS was cultured from 104 patients (41.9%), of whom 33 (33.7%) had microbiological treatment failures on follow-up. Although there was a trend toward failure for younger children (mean 6.5±2.4 years versus 7.3±2.4 years, P=0.07) and M type 12 (24% versus 10%, P=0.08), no factors were associated with treatment failure. |
| format | Article |
| id | doaj-art-7fd8963a91544fc292b23b7ec3369886 |
| institution | Kabale University |
| issn | 1180-2332 |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases |
| spelling | doaj-art-7fd8963a91544fc292b23b7ec33698862025-08-20T03:35:20ZengWileyCanadian Journal of Infectious Diseases1180-23322001-01-01121333910.1155/2001/297304Evaluation of Potential Factors Contributing to Microbiological Treatment Failure in Streptococcus Pyogenes PharyngitisSusan M Kuhn0Jutta Preiksaitis1Gregory J Tyrrell2Taj Jadavji3Deirdre Church4H Dele Davies5Department of Pediatrics, University of Calgary, Calgary, Alberta, CanadaMedical Microbiology and Public Health, University of Alberta Hospitals, Edmonton, Alberta, CanadaDepartment of Pediatrics, University of Calgary, Calgary, Alberta, CanadaDepartment of Pediatrics, University of Calgary, Calgary, Alberta, CanadaDepartment of Medical Microbiology and Infectious Disease, University of Calgary, Calgary, Alberta, CanadaDepartment of Pediatrics, University of Calgary, Calgary, Alberta, CanadaBACKGROUND: A cohort study of children with pharyngitis aged two to 16 years was conducted to assess the role of microbial and host factors in group A beta-hemolytic streptococcus (GABHS) microbiological treatment failure. METHODS: GABHS-infected children had pharyngeal swabs repeated two to five days after completing a 10-day course of penicillin V. M and T typing, and pulsed field gel electrophoresis were performed on the isolates, and the isolates were evaluated for tolerance. Patient characteristics and clinical features were noted and nasopharyngeal swabs for respiratory viruses were taken at enrolment. RESULTS AND CONCLUSIONS: Of 286 patients enrolled, 248 (87%) could be evaluated. GABHS was cultured from 104 patients (41.9%), of whom 33 (33.7%) had microbiological treatment failures on follow-up. Although there was a trend toward failure for younger children (mean 6.5±2.4 years versus 7.3±2.4 years, P=0.07) and M type 12 (24% versus 10%, P=0.08), no factors were associated with treatment failure.http://dx.doi.org/10.1155/2001/297304 |
| spellingShingle | Susan M Kuhn Jutta Preiksaitis Gregory J Tyrrell Taj Jadavji Deirdre Church H Dele Davies Evaluation of Potential Factors Contributing to Microbiological Treatment Failure in Streptococcus Pyogenes Pharyngitis Canadian Journal of Infectious Diseases |
| title | Evaluation of Potential Factors Contributing to Microbiological Treatment Failure in Streptococcus Pyogenes Pharyngitis |
| title_full | Evaluation of Potential Factors Contributing to Microbiological Treatment Failure in Streptococcus Pyogenes Pharyngitis |
| title_fullStr | Evaluation of Potential Factors Contributing to Microbiological Treatment Failure in Streptococcus Pyogenes Pharyngitis |
| title_full_unstemmed | Evaluation of Potential Factors Contributing to Microbiological Treatment Failure in Streptococcus Pyogenes Pharyngitis |
| title_short | Evaluation of Potential Factors Contributing to Microbiological Treatment Failure in Streptococcus Pyogenes Pharyngitis |
| title_sort | evaluation of potential factors contributing to microbiological treatment failure in streptococcus pyogenes pharyngitis |
| url | http://dx.doi.org/10.1155/2001/297304 |
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