Total neoadjuvant therapy in early-onset versus average-onset locally advanced rectal cancer: patient characteristics and tolerance of therapy☆

Total neoadjuvant therapy in early-onset versus average-onset locally advanced rectal cancer: patient characteristics and tolerance of therapy☆

Background: Patients with early-onset (EO, age <50 years) compared with average onset (AO, age ≥50 years) colorectal cancer have significantly higher rates of gastrointestinal toxicity with fluoropyrimidine and oxaliplatin therapy in the metastatic and adjuvant settings. Limited data exist regard...

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Main Authors: M.L. Conces, N. Tursun, I. Ozgur, S. Yilmaz, D. Elamin, S. Patil, Y. Bouferraa, E. Gorgun, D. Liska, E. Weinstein, S.D. Kamath, S.R. Steele, A.A. Khorana, B. Laderian, T.T. Jayakrishnan, K.G. Nair, S.R. Amarnath, E.H. Balagamwala, B.N. Estfan, H. Kessler, M.J. McNamara, M.A. Shapiro, M.A. Valente, S.S. Krishnamurthi
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:ESMO Gastrointestinal Oncology
Subjects:
rectal cancer
early-onset
young-onset
total neoadjuvant therapy
nausea
supportive care
Online Access:http://www.sciencedirect.com/science/article/pii/S2949819825000391
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