Evaluating Obstructive Sleep Apnea Utilizing Arterial Tonometry in Individuals with Cystic Fibrosis
Poor sleep quality and excessive daytime sleepiness are commonly reported by individuals with cystic fibrosis. The potential impact of comorbid sleep-disordered breathing (SDB), particularly obstructive sleep apnea (OSA), has not been extensively studied in the CF population. At present, there are n...
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MDPI AG
2025-06-01
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| Series: | Advances in Respiratory Medicine |
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| Online Access: | https://www.mdpi.com/2543-6031/93/3/20 |
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| author | Michelle Chiu Bethany Bartley Elizabeth Gootkind Salma Batool-Anwar Donald G. Keamy Thomas Bernard Kinane Lael M. Yonker Kevin S. Gipson |
| author_facet | Michelle Chiu Bethany Bartley Elizabeth Gootkind Salma Batool-Anwar Donald G. Keamy Thomas Bernard Kinane Lael M. Yonker Kevin S. Gipson |
| author_sort | Michelle Chiu |
| collection | DOAJ |
| description | Poor sleep quality and excessive daytime sleepiness are commonly reported by individuals with cystic fibrosis. The potential impact of comorbid sleep-disordered breathing (SDB), particularly obstructive sleep apnea (OSA), has not been extensively studied in the CF population. At present, there are no specific recommendations available to help clinicians identify patients with CF who are at increased risk of sleep disorders. Home sleep apnea testing using a validated peripheral arterial tonometry (PAT) device may offer an accurate diagnosis of OSA in a more convenient and low-cost method than in-lab polysomnography. In this single-center study of 19 adults with CF, we found an increased prevalence of OSA among individuals with CF compared to general population estimates. Although associations with an FEV < 70% predicted and a modified Mallampati score ≥ 3 were observed, these odds ratios did not reach statistical significance, likely reflecting limited power in this small pilot sample. There was no association found between the self-reported presence of nocturnal cough or snoring and OSA. We also found no association between OSA and abnormal scores on commonly used, validated sleep questionnaires, suggesting that CF-specific scales may be needed for effective screening in the CF clinic. |
| format | Article |
| id | doaj-art-7fc8c0fb31ff4ad3ab59eb0cdcfad119 |
| institution | Kabale University |
| issn | 2543-6031 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Advances in Respiratory Medicine |
| spelling | doaj-art-7fc8c0fb31ff4ad3ab59eb0cdcfad1192025-08-20T03:26:25ZengMDPI AGAdvances in Respiratory Medicine2543-60312025-06-019332010.3390/arm93030020Evaluating Obstructive Sleep Apnea Utilizing Arterial Tonometry in Individuals with Cystic FibrosisMichelle Chiu0Bethany Bartley1Elizabeth Gootkind2Salma Batool-Anwar3Donald G. Keamy4Thomas Bernard Kinane5Lael M. Yonker6Kevin S. Gipson7Department of Pediatric Pulmonology, Mass General Brigham for Children, Boston, MA 02114, USADepartment of Sleep Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USADepartment of Pediatric Pulmonology, Mass General Brigham for Children, Boston, MA 02114, USADepartment of Sleep Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USADepartment of Otolaryngology-Head & Neck Surgery, Mass Eye & Ear, Boston, MA 02114, USADepartment of Pediatric Pulmonology, Mass General Brigham for Children, Boston, MA 02114, USADepartment of Pediatric Pulmonology, Mass General Brigham for Children, Boston, MA 02114, USADepartment of Pediatric Pulmonology, Mass General Brigham for Children, Boston, MA 02114, USAPoor sleep quality and excessive daytime sleepiness are commonly reported by individuals with cystic fibrosis. The potential impact of comorbid sleep-disordered breathing (SDB), particularly obstructive sleep apnea (OSA), has not been extensively studied in the CF population. At present, there are no specific recommendations available to help clinicians identify patients with CF who are at increased risk of sleep disorders. Home sleep apnea testing using a validated peripheral arterial tonometry (PAT) device may offer an accurate diagnosis of OSA in a more convenient and low-cost method than in-lab polysomnography. In this single-center study of 19 adults with CF, we found an increased prevalence of OSA among individuals with CF compared to general population estimates. Although associations with an FEV < 70% predicted and a modified Mallampati score ≥ 3 were observed, these odds ratios did not reach statistical significance, likely reflecting limited power in this small pilot sample. There was no association found between the self-reported presence of nocturnal cough or snoring and OSA. We also found no association between OSA and abnormal scores on commonly used, validated sleep questionnaires, suggesting that CF-specific scales may be needed for effective screening in the CF clinic.https://www.mdpi.com/2543-6031/93/3/20cystic fibrosisobstructive sleep apneahome sleep apnea testingperipheral arterial tonometry |
| spellingShingle | Michelle Chiu Bethany Bartley Elizabeth Gootkind Salma Batool-Anwar Donald G. Keamy Thomas Bernard Kinane Lael M. Yonker Kevin S. Gipson Evaluating Obstructive Sleep Apnea Utilizing Arterial Tonometry in Individuals with Cystic Fibrosis Advances in Respiratory Medicine cystic fibrosis obstructive sleep apnea home sleep apnea testing peripheral arterial tonometry |
| title | Evaluating Obstructive Sleep Apnea Utilizing Arterial Tonometry in Individuals with Cystic Fibrosis |
| title_full | Evaluating Obstructive Sleep Apnea Utilizing Arterial Tonometry in Individuals with Cystic Fibrosis |
| title_fullStr | Evaluating Obstructive Sleep Apnea Utilizing Arterial Tonometry in Individuals with Cystic Fibrosis |
| title_full_unstemmed | Evaluating Obstructive Sleep Apnea Utilizing Arterial Tonometry in Individuals with Cystic Fibrosis |
| title_short | Evaluating Obstructive Sleep Apnea Utilizing Arterial Tonometry in Individuals with Cystic Fibrosis |
| title_sort | evaluating obstructive sleep apnea utilizing arterial tonometry in individuals with cystic fibrosis |
| topic | cystic fibrosis obstructive sleep apnea home sleep apnea testing peripheral arterial tonometry |
| url | https://www.mdpi.com/2543-6031/93/3/20 |
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