A Clinicoimmunohistopathologic Study of Anetoderma: Is Protruding Type More Advanced in Stage Than Indented Type?
Background. The clinical and histopathologic classification of anetoderma are not well characterized. Objective. We aimed to investigate the clinical and histopathologic characteristics of anetoderma and to correlate clinical phenotypes with immunohistopathologic findings. Methods. We retrospectivel...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/4325463 |
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| author | Jung Eun Kim Ki Min Sohn Young Jun Woo Kwan Ho Jeong Miri Kim Jeong Deuk Lee Jun Young Lee Hyun Jeong Park Gyong Moon Kim Chul Jong Park Dong Soo Yu Hoon Kang |
| author_facet | Jung Eun Kim Ki Min Sohn Young Jun Woo Kwan Ho Jeong Miri Kim Jeong Deuk Lee Jun Young Lee Hyun Jeong Park Gyong Moon Kim Chul Jong Park Dong Soo Yu Hoon Kang |
| author_sort | Jung Eun Kim |
| collection | DOAJ |
| description | Background. The clinical and histopathologic classification of anetoderma are not well characterized. Objective. We aimed to investigate the clinical and histopathologic characteristics of anetoderma and to correlate clinical phenotypes with immunohistopathologic findings. Methods. We retrospectively reviewed the medical records of 30 patients with anetoderma and performed immunohistochemistry for elastin, fibrillin-1, metalloproteinase- (MMP-) 2, MMP-7, MMP-9, and MMP-12, and tissue inhibitor of metalloproteinase- (TIMP-) 1 and TIMP-2. Results. Protruding type (n = 17) had a longer disease duration and more severe loss of elastin, without changes in fibrillin, than indented type (n = 13). MMP-2 and MMP-9 showed significantly higher expressions in the dermis compared with controls (p < 0.05). MMP-7 and MMP-12 showed little expressions in both anetoderma and control tissue. TIMP-1 was highly expressed in anetoderma lesions and controls. TIMP-2 expression was variable. Conclusions. Our findings suggest that protruding type anetoderma may represent a more advanced stage and that MMP-2 and MMP-9 could be responsible for elastic fiber degradation in anetoderma. |
| format | Article |
| id | doaj-art-7fc8091c44fe4517b912785aaa73eb42 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-7fc8091c44fe4517b912785aaa73eb422025-08-20T03:35:20ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/43254634325463A Clinicoimmunohistopathologic Study of Anetoderma: Is Protruding Type More Advanced in Stage Than Indented Type?Jung Eun Kim0Ki Min Sohn1Young Jun Woo2Kwan Ho Jeong3Miri Kim4Jeong Deuk Lee5Jun Young Lee6Hyun Jeong Park7Gyong Moon Kim8Chul Jong Park9Dong Soo Yu10Hoon Kang11Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaBackground. The clinical and histopathologic classification of anetoderma are not well characterized. Objective. We aimed to investigate the clinical and histopathologic characteristics of anetoderma and to correlate clinical phenotypes with immunohistopathologic findings. Methods. We retrospectively reviewed the medical records of 30 patients with anetoderma and performed immunohistochemistry for elastin, fibrillin-1, metalloproteinase- (MMP-) 2, MMP-7, MMP-9, and MMP-12, and tissue inhibitor of metalloproteinase- (TIMP-) 1 and TIMP-2. Results. Protruding type (n = 17) had a longer disease duration and more severe loss of elastin, without changes in fibrillin, than indented type (n = 13). MMP-2 and MMP-9 showed significantly higher expressions in the dermis compared with controls (p < 0.05). MMP-7 and MMP-12 showed little expressions in both anetoderma and control tissue. TIMP-1 was highly expressed in anetoderma lesions and controls. TIMP-2 expression was variable. Conclusions. Our findings suggest that protruding type anetoderma may represent a more advanced stage and that MMP-2 and MMP-9 could be responsible for elastic fiber degradation in anetoderma.http://dx.doi.org/10.1155/2016/4325463 |
| spellingShingle | Jung Eun Kim Ki Min Sohn Young Jun Woo Kwan Ho Jeong Miri Kim Jeong Deuk Lee Jun Young Lee Hyun Jeong Park Gyong Moon Kim Chul Jong Park Dong Soo Yu Hoon Kang A Clinicoimmunohistopathologic Study of Anetoderma: Is Protruding Type More Advanced in Stage Than Indented Type? Journal of Immunology Research |
| title | A Clinicoimmunohistopathologic Study of Anetoderma: Is Protruding Type More Advanced in Stage Than Indented Type? |
| title_full | A Clinicoimmunohistopathologic Study of Anetoderma: Is Protruding Type More Advanced in Stage Than Indented Type? |
| title_fullStr | A Clinicoimmunohistopathologic Study of Anetoderma: Is Protruding Type More Advanced in Stage Than Indented Type? |
| title_full_unstemmed | A Clinicoimmunohistopathologic Study of Anetoderma: Is Protruding Type More Advanced in Stage Than Indented Type? |
| title_short | A Clinicoimmunohistopathologic Study of Anetoderma: Is Protruding Type More Advanced in Stage Than Indented Type? |
| title_sort | clinicoimmunohistopathologic study of anetoderma is protruding type more advanced in stage than indented type |
| url | http://dx.doi.org/10.1155/2016/4325463 |
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